Guanine-nucleotide-releasing factor hSos1 binds to Grb2 and links receptor tyrosine kinases to Ras signalling (Q28268458)

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R Daly

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V Yajnik

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E Skolnik

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P Chardin

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D Bar-Sagi

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B Margolis

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J Schlessinger

Signal transduction by receptors with tyrosine kinase activity

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language of work or name

English

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publication date

6 May 1993

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published in

Nature

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volume

363

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issue

6424

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page(s)

85-8

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cites work

1 reference

7 January 2021

Accumulation of p21ras.GTP in response to stimulation with epidermal growth factor and oncogene products with tyrosine kinase activity

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7 January 2021

Platelet-derived growth factor stimulates formation of active p21ras.GTP complex in Swiss mouse 3T3 cells

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Mechanistic aspects of signaling through Ras in NIH 3T3 cells

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Ras activation by insulin and epidermal growth factor through enhanced exchange of guanine nucleotides on p21ras

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7 January 2021

Requirement for ras proto-oncogene function during serum-stimulated growth of NIH 3T3 cells

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Requirement for c-ras proteins during viral oncogene transformation

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Inhibition of growth factor-induced differentiation of PC12 cells by microinjection of antibody to ras p21

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7 January 2021

Ras is essential for nerve growth factor- and phorbol ester-induced tyrosine phosphorylation of MAP kinases

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7 January 2021

ras mediates nerve growth factor receptor modulation of three signal-transducing protein kinases: MAP kinase, Raf-1, and RSK

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7 January 2021

Involvement of p21ras in activation of extracellular signal-regulated kinase 2.

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7 January 2021

Effect of a dominant inhibitory Ha-ras mutation on neuronal differentiation of PC12 cells

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7 January 2021

The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling

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7 January 2021

C. elegans cell-signalling gene sem-5 encodes a protein with SH2 and SH3 domains

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7 January 2021

The let-23 gene necessary for Caenorhabditis elegans vulval induction encodes a tyrosine kinase of the EGF receptor subfamily

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7 January 2021

Caenorhabditis elegans ras gene let-60 acts as a switch in the pathway of vulval induction

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7 January 2021

Identification of murine homologues of the Drosophila son of sevenless gene: potential activators of ras

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7 January 2021

Ras1 and a putative guanine nucleotide exchange factor perform crucial steps in signaling by the sevenless protein tyrosine kinase.

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7 January 2021

Genetic dissection of a neurodevelopmental pathway: Son of sevenless functions downstream of the sevenless and EGF receptor tyrosine kinases

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7 January 2021

Association of the Shc and Grb2/Sem5 SH2-containing proteins is implicated in activation of the Ras pathway by tyrosine kinases

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7 January 2021

Identification of a protein that binds to the SH3 region of Abl and is similar to Bcr and GAP-rho

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7 January 2021

SH2 domains exhibit high-affinity binding to tyrosine-phosphorylated peptides yet also exhibit rapid dissociation and exchange

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7 January 2021

A Drosophila SH2-SH3 adaptor protein implicated in coupling the sevenless tyrosine kinase to an activator of Ras guanine nucleotide exchange, Sos.

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7 January 2021

An SH3-SH2-SH3 protein is required for p21Ras1 activation and binds to sevenless and Sos proteins in vitro

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7 January 2021

Phosphorylation of the S. cerevisiae Cdc25 in response to glucose results in its dissociation from Ras

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7 January 2021

Tyrosine phosphorylation of vav proto-oncogene product containing SH2 domain and transcription factor motifs

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7 January 2021