Meclizine is neuroprotective in models of Huntington's disease (Q34424265)

2 August 2017

title

Meclizine is neuroprotective in models of Huntington's disease (English)

1 reference

2 August 2017

0 references

James F Gusella

1 reference

2 August 2017

Marcy E MacDonald

1 reference

2 August 2017

Elisa Fossale

1 reference

2 August 2017

Vamsi K Mootha

1 reference

2 August 2017

Christian Neri

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20977989

10 August 2024

Nicolas Offner

1 reference

2 August 2017

Vishal M. Gohil

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20977989

10 August 2024

James A. Walker

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20977989

10 August 2024

Sunil A. Sheth

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20977989

10 August 2024

Vamsi K. Mootha

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20977989

10 August 2024

language of work or name

English

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National Center for Biotechnology Information

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=20977989

10 August 2024

publication date

25 October 2010

1 reference

full work available at URL

2 August 2017

https://academic.oup.com/hmg/article-pdf/20/2/294/1847583/ddq464.pdf

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20977989

http://hmg.oxfordjournals.org/cgi/content/abstract/20/2/294

10 August 2024

online access status

open access

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20977989

https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20977989/?tool=EBI

10 August 2024

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20977989

https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20977989/pdf/?tool=EBI

10 August 2024

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20977989

https://europepmc.org/articles/PMC3005902

10 August 2024

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20977989

https://europepmc.org/articles/PMC3005902?pdf=render

10 August 2024

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20977989

https://doi.org/10.1093/hmg/ddq464

10 August 2024

online access status

open access

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20977989

http://academic.oup.com/hmg/article-pdf/20/2/294/1847583/ddq464.pdf

10 August 2024

1 reference

https://api.crossref.org/works/10.1093/HMG/DDQ464

10 August 2024

published in

Human Molecular Genetics

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2 August 2017

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2 August 2017

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2 August 2017

page(s)

294-300

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Nutrient-sensitized screening for drugs that shift energy metabolism from mitochondrial respiration to glycolysis

2 August 2017

cites work

1 reference

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Mitochondria and Huntington's disease pathogenesis: insight from genetic and chemical models

6 July 2018

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Inhibitors of cytochrome c release with therapeutic potential for Huntington's disease

6 July 2018

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6 July 2018

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Inhibitors of metabolism rescue cell death in Huntington's disease models.

6 July 2018

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6 July 2018

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Unbiased gene expression analysis implicates the huntingtin polyglutamine tract in extra-mitochondrial energy metabolism

6 July 2018

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Apoptotic cascades as possible targets for inhibiting cell death in Huntington's disease

6 July 2018

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Multiparameter metabolic analysis reveals a close link between attenuated mitochondrial bioenergetic function and enhanced glycolysis dependency in human tumor cells

6 July 2018

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6 July 2018

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6 July 2018

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The energetics of Huntington's disease

6 July 2018

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Cytoplasmic aggregates trap polyglutamine-containing proteins and block axonal transport in a Drosophila model of Huntington's disease.

6 July 2018

1 reference

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Targeting programmed cell death in neurodegenerative diseases

6 July 2018

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Discovery of molecular mechanisms of neuroprotection using cell-based bioassays and oligonucleotide arrays

6 July 2018

1 reference

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Lessons from animal models of Huntington's disease

6 July 2018

1 reference

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Expanded polyglutamines in Caenorhabditis elegans cause axonal abnormalities and severe dysfunction of PLM mechanosensory neurons without cell death

6 July 2018

1 reference

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Early degenerative changes in transgenic mice expressing mutant huntingtin involve dendritic abnormalities but no impairment of mitochondrial energy production

6 July 2018

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Reduction of glyceraldehyde-3-phosphate dehydrogenase activity in Alzheimer's disease and in Huntington's disease fibroblasts

6 July 2018

1 reference

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Inhibition of caspase-1 slows disease progression in a mouse model of Huntington's disease

6 July 2018

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Caspase-8 is required for cell death induced by expanded polyglutamine repeats.

6 July 2018

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6 July 2018

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Oxidative damage and metabolic dysfunction in Huntington's disease: selective vulnerability of the basal ganglia.

6 July 2018

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Striatal glucose metabolism and dopamine D2 receptor binding in asymptomatic gene carriers and patients with Huntington's disease

6 July 2018

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A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes.

6 July 2018

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The relationship between trinucleotide (CAG) repeat length and clinical features of Huntington's disease

6 July 2018

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Relationship between trinucleotide repeat expansion and phenotypic variation in Huntington's disease

6 July 2018

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Local cerebral glucose utilization in symptomatic and presymptomatic Huntington's disease

6 July 2018

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Distribution of phosphate-activated glutaminase, succinic dehydrogenase, pyruvate dehydrogenase and gamma-glutamyl transpeptidase in post-mortem brain from Huntington's disease and agonal cases

6 July 2018

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6 July 2018

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6 July 2018

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Mitochondrial haplogroup H correlates with ATP levels and age at onset in Huntington disease.

6 July 2018

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PGC-1alpha as modifier of onset age in Huntington disease

27 October 2018

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27 October 2018

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Can drug screening lead to candidate therapies for testing in diabetic neuropathy?

27 October 2018

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Can radiation-induced apoptosis be modulated by inhibitors of energy metabolism?

27 October 2018

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HD CAG repeat implicates a dominant property of huntingtin in mitochondrial energy metabolism

27 October 2018

1 reference

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Modification of glycolysis affects cell sensitivity to apoptosis induced by oxidative stress and mediated by mitochondria

27 October 2018

1 reference

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Dominant phenotypes produced by the HD mutation in STHdh(Q111) striatal cells

27 October 2018

1 reference

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Polyglutamine-expanded human huntingtin transgenes induce degeneration of Drosophila photoreceptor neurons.

27 October 2018

1 reference

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Mitochondrial defect in Huntington's disease caudate nucleus

27 October 2018

1 reference

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Striatal glucose consumption in chorea-free subjects at risk of Huntington's disease

27 October 2018

1 reference

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Research publications - Association for Research in Nervous and Mental Disease

27 October 2018

199

Kuhl

1985

1 reference

https://api.crossref.org/works/10.1093/HMG/DDQ464

10 August 2024

Identifiers

DOI

10.1093/HMG/DDQ464

1 reference

2 August 2017

1 reference

2 August 2017

1 reference