A 24-residue peptide (p5), derived from p35, the Cdk5 neuronal activator, specifically inhibits Cdk5-p25 hyperactivity and tau hyperphosphorylation (Q34232193)

From Wikidata

Jump to navigation Jump to search

scientific article

Language	Label	Description	Also known as
English	A 24-residue peptide (p5), derived from p35, the Cdk5 neuronal activator, specifically inhibits Cdk5-p25 hyperactivity and tau hyperphosphorylation	scientific article

Statements

scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

A 24-residue peptide (p5), derived from p35, the Cdk5 neuronal activator, specifically inhibits Cdk5-p25 hyperactivity and tau hyperphosphorylation (English)

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

author name string

Ya-Li Zheng

1

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

Niranjana D Amin

2

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

Ya-Fang Hu

3

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

Parvathi Rudrabhatla

4

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

Varsha Shukla

5

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

Jyotshnabala Kanungo

6

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

Sashi Kesavapany

7

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

Philip Grant

8

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

Wayne Albers

9

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

Harish C Pant

10

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

language of work or name

0 references

publication date

18 August 2010

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

Journal of Biological Chemistry

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

285

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

44

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

34202-34212

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

Cholesterol metabolism and transport in the pathogenesis of Alzheimer's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2962518

6 July 2018

Potent and cellularly active 4-aminoimidazole inhibitors of cyclin-dependent kinase 5/p25 for the treatment of Alzheimer's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2962518

6 July 2018

Specific inhibition of cyclin-dependent kinase 5 activity induces motor neuron development in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2962518

6 July 2018

The molecular and cellular pathogenesis of dementia of the Alzheimer's type an overview

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2962518

6 July 2018

Recent advances in understanding the roles of Cdk5 in synaptic plasticity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2962518

6 July 2018

Molecular mechanisms of excitotoxicity and their relevance to pathogenesis of neurodegenerative diseases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2962518

6 July 2018

Zebrafish Rohon-Beard neuron development: cdk5 in the midst

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2962518

6 July 2018

Pin1-dependent prolyl isomerization modulates the stress-induced phosphorylation of high molecular weight neurofilament protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2962518

6 July 2018

Cyclin-dependent kinase 5 phosphorylation of human septin SEPT5 (hCDCrel-1) modulates exocytosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2962518

6 July 2018

Calmodulin binding and Cdk5 phosphorylation of p35 regulate its effect on microtubules

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2962518

6 July 2018

New approaches to the discovery of cdk5 inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2962518

6 July 2018

A novel approach to cyclin-dependent kinase 5/p25 inhibitors: A potential treatment for Alzheimer's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2962518

6 July 2018

Peptides derived from Cdk5 activator p35, specifically inhibit deregulated activity of Cdk5.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2962518

6 July 2018

Cell cycle regulation in the postmitotic neuron: oxymoron or new biology?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2962518

6 July 2018

Cdk5 Modulation of mitogen-activated protein kinase signaling regulates neuronal survival

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2962518

6 July 2018

PKA modulates GSK-3beta- and cdk5-catalyzed phosphorylation of tau in site- and kinase-specific manners

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2962518

6 July 2018

Cyclin-dependent kinase 5 in synaptic plasticity, learning and memory.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2962518

6 July 2018

Signaling mechanisms underlying Abeta toxicity: potential therapeutic targets for Alzheimer's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2962518

6 July 2018

Synaptic roles of Cdk5: implications in higher cognitive functions and neurodegenerative diseases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2962518

6 July 2018

Suppression of cyclin-dependent kinase 5 activation by amyloid precursor protein: a novel excitoprotective mechanism involving modulation of tau phosphorylation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2962518

6 July 2018

Activation of latent cyclin-dependent kinase 5 (Cdk5)-p35 complexes by membrane dissociation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2962518

6 July 2018

The cell cycle in Alzheimer disease: a unique target for neuropharmacology

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2962518

6 July 2018

A Cdk5 inhibitory peptide reduces tau hyperphosphorylation and apoptosis in neurons

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2962518

6 July 2018

Divide and die: cell cycle events as triggers of nerve cell death.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2962518

6 July 2018

Neuronal cyclin-dependent kinase 5: role in nervous system function and its specific inhibition by the Cdk5 inhibitory peptide

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2962518

6 July 2018

Cdk5, a therapeutic target for Alzheimer's disease?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2962518

6 July 2018

Cdk5 in the adult non-demented brain.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2962518

6 July 2018

Protein-protein interactions in Cdk5 regulation and function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2962518

6 July 2018

The regulation of cyclin-dependent kinase 5 activity through the metabolism of p35 or p39 Cdk5 activator

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2962518

6 July 2018

Aberrant Cdk5 activation by p25 triggers pathological events leading to neurodegeneration and neurofibrillary tangles

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2962518

6 July 2018

Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2962518

6 July 2018

Phosphorylation of the head domain of neurofilament protein (NF-M): a factor regulating topographic phosphorylation of NF-M tail domain KSP sites in neurons

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2962518

6 July 2018

Cdk5 as a drug target for the treatment of Alzheimer's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2962518

6 July 2018

Cycling at the interface between neurodevelopment and neurodegeneration

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2962518

6 July 2018

A survey of Cdk5 activator p35 and p25 levels in Alzheimer's disease brains

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2962518

6 July 2018

Cyclin-dependent kinase 5 is required for associative learning

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2962518

6 July 2018

Cdk5 behind the wheel: a role in trafficking and transport?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2962518

6 July 2018

The protein SET binds the neuronal Cdk5 activator p35nck5a and modulates Cdk5/p35nck5a activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2962518

6 July 2018

A decade of CDK5.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2962518

6 July 2018

Deregulation of Cdk5 in a mouse model of ALS: toxicity alleviated by perikaryal neurofilament inclusions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2962518

6 July 2018

The protein kinase Cdk5. Structural aspects, roles in neurogenesis and involvement in Alzheimer's pathology

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2962518

6 July 2018

Neurotoxicity induces cleavage of p35 to p25 by calpain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2962518

6 July 2018

Hyperphosphorylated tau and neurofilament and cytoskeletal disruptions in mice overexpressing human p25, an activator of cdk5

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2962518

6 July 2018

Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2962518

6 July 2018

Migration defects of cdk5(-/-) neurons in the developing cerebellum is cell autonomous

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2962518

6 July 2018

Cyclin-dependent kinase 5-deficient mice demonstrate novel developmental arrest in cerebral cortex

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2962518

6 July 2018

Cyclin-dependent kinase 5 (Cdk5) and neuron-specific Cdk5 activators

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2962518

6 July 2018

A simplified system for generating recombinant adenoviruses

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2962518

6 July 2018

Mice lacking p35, a neuronal specific activator of Cdk5, display cortical lamination defects, seizures, and adult lethality

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2962518

6 July 2018

Targeted disruption of the cyclin-dependent kinase 5 gene results in abnormal corticogenesis, neuronal pathology and perinatal death

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2962518

6 July 2018

The cdk5/p35 kinase is essential for neurite outgrowth during neuronal differentiation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2962518

6 July 2018

Neurotrophic and neurotoxic effects of amyloid beta protein: reversal by tachykinin neuropeptides

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2962518

6 July 2018

Opposing roles of transient and prolonged expression of p25 in synaptic plasticity and hippocampus-dependent memory

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.134643

21 January 2018

Cdk5 is a key factor in tau aggregation and tangle formation in vivo

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.134643

21 January 2018

A peptide derived from cyclin-dependent kinase activator (p35) specifically inhibits Cdk5 activity and phosphorylation of tau protein in transfected cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.134643

21 January 2018

Microtubule association of the neuronal p35 activator of Cdk5.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.134643

21 January 2018

Targeting Cdk5 activity in neuronal degeneration and regeneration

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.134643

21 January 2018

Neuronal nuclear organization is controlled by cyclin-dependent kinase 5 phosphorylation of Ras Guanine nucleotide releasing factor-1.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.134643

21 January 2018

Cyclin-dependent kinase 5 increases perikaryal neurofilament phosphorylation and inhibits neurofilament axonal transport in response to oxidative stress

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.134643

21 January 2018

Region-specific expression of cyclin-dependent kinase 5 (cdk5) and its activators, p35 and p39, in the developing and adult rat central nervous system

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.134643

21 January 2018

Kinetic studies of Cdk5/p25 kinase: phosphorylation of tau and complex inhibition by two prototype inhibitors

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.134643

21 January 2018

p25/cyclin-dependent kinase 5 induces production and intraneuronal accumulation of amyloid beta in vivo.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.134643

21 January 2018

Cerebrolysin decreases amyloid-beta production by regulating amyloid protein precursor maturation in a transgenic model of Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.134643

21 January 2018

Calpain-mediated degradation of p35 to p25 in postmortem human and rat brains

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.134643

21 January 2018

A Cdk5-p35 stable complex is involved in the beta-amyloid-induced deregulation of Cdk5 activity in hippocampal neurons

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.134643

21 January 2018

Inhibition of tau phosphorylating protein kinase cdk5 prevents beta-amyloid-induced neuronal death

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.134643

21 January 2018

Intracellular Targets of Paullones. Identification following affinity purification on immobilized inhibitor

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.134643

21 January 2018

Mitogen-activated protein kinases (Erk1,2) phosphorylate Lys-Ser-Pro (KSP) repeats in neurofilament proteins NF-H and NF-M.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2962518

28 October 2018

Processing of cdk5 Activator p35 to Its Truncated Form (p25) by Calpain in Acutely Injured Neuronal Cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.134643

21 January 2018

Stereoselective synthesis of cis-1,3-disubstituted cyclobutyl kinase inhibitors

1 reference

https://pubmed.ncbi.nlm.nih.gov/20720012

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

reply: Neurobiologyp25 protein in neurodegeneration

1 reference

https://pubmed.ncbi.nlm.nih.gov/20720012

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of nuclear import mechanisms for the neuronal Cdk5 activator

1 reference

https://pubmed.ncbi.nlm.nih.gov/20720012

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Calpain-dependent proteolytic cleavage of the p35 cyclin-dependent kinase 5 activator to p25

1 reference

https://pubmed.ncbi.nlm.nih.gov/20720012

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

p35/Cdk5 pathway mediates soluble amyloid-beta peptide-induced tau phosphorylation in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/20720012

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1074/JBC.M110.134643

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

ResearchGate publication ID

0 references

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

Retrieved from "https://www.wikidata.org/w/index.php?title=Q34232193&oldid=1620893436"