Germinal center B cell maintenance and differentiation are controlled by distinct NF-κB transcription factor subunits (Q34230576)

31 July 2017

title

Germinal center B cell maintenance and differentiation are controlled by distinct NF-κB transcription factor subunits (English)

1 reference

31 July 2017

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Giorgia Simonetti

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Manolis Pasparakis

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Nicole Heise

1 reference

31 July 2017

Nilushi S De Silva

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31 July 2017

Kathryn Silva

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31 July 2017

Amanda Carette

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31 July 2017

Ulf Klein

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31 July 2017

language of work or name

English

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publication date

1 September 2014

1 reference

Journal of Experimental Medicine

31 July 2017

published in

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31 July 2017

volume

211

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31 July 2017

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31 July 2017

page(s)

2103-2118

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Clonal selection in the germinal centre by regulated proliferation and hypermutation

31 July 2017

cites work

1 reference

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Germinal center centroblasts transition to a centrocyte phenotype according to a timed program and depend on the dark zone for effective selection.

6 July 2018

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The transcription factor IRF4 is essential for TCR affinity-mediated metabolic programming and clonal expansion of T cells

6 July 2018

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Control of amino-acid transport by antigen receptors coordinates the metabolic reprogramming essential for T cell differentiation

6 July 2018

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The cell-cycle regulator c-Myc is essential for the formation and maintenance of germinal centers

6 July 2018

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Metabolic switching and fuel choice during T-cell differentiation and memory development

6 July 2018

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B cell receptor signal transduction in the GC is short-circuited by high phosphatase activity

6 July 2018

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The diverse roles of IRF4 in late germinal center B-cell differentiation

6 July 2018

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NF-κB function in B lymphocytes

6 July 2018

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Glucose-independent glutamine metabolism via TCA cycling for proliferation and survival in B cells

6 July 2018

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6 July 2018

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Pathogenesis of human B cell lymphomas

6 July 2018

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The transcription factor Myc controls metabolic reprogramming upon T lymphocyte activation

6 July 2018

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NF-κB controls energy homeostasis and metabolic adaptation by upregulating mitochondrial respiration

6 July 2018

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Signatures of murine B-cell development implicate Yy1 as a regulator of the germinal center-specific program

6 July 2018

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Germinal center dynamics revealed by multiphoton microscopy with a photoactivatable fluorescent reporter

6 July 2018

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Mcl-1 is essential for germinal center formation and B cell memory

6 July 2018

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Roles of the NF-kappaB pathway in lymphocyte development and function

6 July 2018

1 reference

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Selectivity of the NF-{kappa}B response

6 July 2018

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Single round of antigen receptor signaling programs naive B cells to receive T cell help

6 July 2018

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Blimp-1/Prdm1 alternative promoter usage during mouse development and plasma cell differentiation

6 July 2018

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Mutations of multiple genes cause deregulation of NF-kappaB in diffuse large B-cell lymphoma.

6 July 2018

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Frequent inactivation of A20 in B-cell lymphomas

6 July 2018

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TNFAIP3 (A20) is a tumor suppressor gene in Hodgkin lymphoma and primary mediastinal B cell lymphoma

6 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4172226

Regulation and function of NF-kappaB transcription factors in the immune system

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4172226

IKK1 and IKK2 cooperate to maintain bile duct integrity in the liver

6 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4172226

Oncogenic CARD11 mutations in human diffuse large B cell lymphoma

6 July 2018

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Germinal centres: role in B-cell physiology and malignancy

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4172226

Germinal-center organization and cellular dynamics

6 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4172226

Frequent engagement of the classical and alternative NF-kappaB pathways by diverse genetic abnormalities in multiple myeloma

6 July 2018

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Tracking germinal center B cells expressing germ-line immunoglobulin gamma1 transcripts by conditional gene targeting

6 July 2018

1 reference

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Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles

6 July 2018

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6 July 2018

Signaling to NF-kappaB

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Tracking CD40 signaling during germinal center development

6 July 2018

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The role of Rel/NF-kappaB transcription factors in B lymphocyte survival

6 July 2018

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The combined absence of NF-kappa B1 and c-Rel reveals that overlapping roles for these transcription factors in the B cell lineage are restricted to the activation and function of mature cells

6 July 2018

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Gene expression profiling of B cell chronic lymphocytic leukemia reveals a homogeneous phenotype related to memory B cells.

6 July 2018

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Signatures of the immune response

6 July 2018

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bcl-2 transgene expression inhibits apoptosis in the germinal center and reveals differences in the selection of memory B cells and bone marrow antibody-forming cells

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4172226

Multiple mutations contribute to the oncogenicity of the retroviral oncoprotein v-Rel

6 July 2018

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Multiple hemopoietic defects and lymphoid hyperplasia in mice lacking the transcriptional activation domain of the c-Rel protein

6 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4172226

NF-kappa B RelA-deficient lymphocytes: normal development of T cells and B cells, impaired production of IgA and IgG1 and reduced proliferative responses

6 July 2018

1 reference

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B lymphocyte-specific, Cre-mediated mutagenesis in mice

6 July 2018

1 reference

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Clonal selection and learning in the antibody system

6 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4172226

In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. III. The kinetics of V region mutation and selection in germinal center B cells

6 July 2018

1 reference

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6 July 2018

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Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-κB

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4172226

Cellular interaction in germinal centers. Roles of CD40 ligand and B7-2 in established germinal centers.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4172226

bcl-2-immunoglobulin transgenic mice demonstrate extended B cell survival and follicular lymphoproliferation

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4172226

The proto-oncogene MYC is required for selection in the germinal center and cyclic reentry

6 July 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20132613

Transcription factor IRF4 controls plasma cell differentiation and class-switch recombination.

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20132613

A signaling pathway mediating downregulation of BCL6 in germinal center B cells is blocked by BCL6 gene alterations in B cell lymphoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20132613

BCL-6 represses genes that function in lymphocyte differentiation, inflammation, and cell cycle control.

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20132613

Blimp-1 Is Required for the Formation of Immunoglobulin Secreting Plasma Cells and Pre-Plasma Memory B Cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20132613

c-Rel is essential for B lymphocyte survival and cell cycle progression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20132613

B Cell Growth Is Controlled by Phosphatidylinosotol 3-Kinase-Dependent Induction of Rel/NF-κB Regulated c-myc Transcription

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25180063

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Mice lacking the c-rel proto-oncogene exhibit defects in lymphocyte proliferation, humoral immunity, and interleukin-2 expression

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25180063

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Graded expression of interferon regulatory factor-4 coordinates isotype switching with plasma cell differentiation

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25180063

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1084/JEM.20132613

1 reference

31 July 2017

1 reference

31 July 2017

1 reference