Diversity-oriented synthesis: producing chemical tools for dissecting biology (Q34227440)

31 July 2017

title

Diversity-oriented synthesis: producing chemical tools for dissecting biology (English)

1 reference

31 July 2017

David R Spring

0 references

Cornelius J O' Connor

series ordinal

1 reference

31 July 2017

Henning S G Beckmann

series ordinal

1 reference

31 July 2017

publication date

10 April 2012

1 reference

31 July 2017

published in

Chemical Society Reviews

1 reference

31 July 2017

1 reference

31 July 2017

1 reference

31 July 2017

page(s)

4444-4456

1 reference

Chemical genetics resulting from a passion for synthetic organic chemistry

31 July 2017

cites work

1 reference

https://api.crossref.org/works/10.1039%2FC2CS35023H

Chemical genetics: ligand-based discovery of gene function

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CS35023H

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CS35023H

Spiroindolones, a potent compound class for the treatment of malaria

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CS35023H

Diversity through phosphine catalysis identifies octahydro-1,6-naphthyridin-4-ones as activators of endothelium-driven immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CS35023H

Retinoic acid synthesis and signaling during early organogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CS35023H

Small molecules: the missing link in the central dogma

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CS35023H

Chemical control of stem cell fate and developmental potential

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CS35023H

A role for fucose alpha(1-2) galactose carbohydrates in neuronal growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CS35023H

Exploring biology with small organic molecules

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CS35023H

The emerging role of pharmacogenomics in biologics

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CS35023H

Development trends for human monoclonal antibody therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CS35023H

Combination chemical genetics

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CS35023H

Chemical genetics to chemical genomics: small molecules offer big insights

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CS35023H

Impact of high-throughput screening in biomedical research

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CS35023H

HTS and hit finding in academia--from chemical genomics to drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CS35023H

Trends in the exploitation of novel drug targets

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CS35023H

Solid-phase synthesis and chemical space analysis of a 190-membered alkaloid/terpenoid-like library

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CS35023H

Discovery of new antimalarial chemotypes through chemical methodology and library development

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CS35023H

Target-oriented and diversity-oriented organic synthesis in drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CS35023H

Diversity-oriented synthesis as a tool for the discovery of novel biologically active small molecules

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CS35023H

Diversity-oriented synthesis: exploring the intersections between chemistry and biology

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CS35023H

The art and practice of structure-based drug design: A molecular modeling perspective

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CS35023H

Natural products as sources of new drugs over the last 25 years

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CS35023H

Molecular shape diversity of combinatorial libraries: a prerequisite for broad bioactivity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CS35023H

Small molecules of different origins have distinct distributions of structural complexity that correlate with protein-binding profiles

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CS35023H

Escape from flatland: increasing saturation as an approach to improving clinical success

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CS35023H

Multidimensional chemical genetic analysis of diversity-oriented synthesis-derived deacetylase inhibitors using cell-based assays

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CS35023H

Drug discovery and natural products: end of an era or an endless frontier?

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CS35023H

Natural products in drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CS35023H

Quantifying biogenic bias in screening libraries

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CS35023H

A planning strategy for diversity-oriented synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CS35023H

Towards the optimal screening collection: a synthesis strategy

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CS35023H

Branching cascades: a concise synthetic strategy targeting diverse and complex molecular frameworks.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CS35023H

Anti-MRSA agent discovery using diversity-oriented synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CS35023H

Synthesis of natural-product-like molecules with over eighty distinct scaffolds

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CS35023H

Creation and manipulation of common functional groups en route to a skeletally diverse chemical library

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CS35023H

Stereochemical and skeletal diversity arising from amino propargylic alcohols

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CS35023H

Skeletally diverse small molecules using a build/couple/pair strategy

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CS35023H

Diversity-oriented synthesis of macrocyclic peptidomimetics

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CS35023H

High-throughput screening for modulators of protein-protein interactions: use of photonic crystal biosensors and complementary technologies

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CS35023H

Small-molecule inhibitors of protein-protein interactions: progressing towards the dream

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CS35023H

Reaching for high-hanging fruit in drug discovery at protein-protein interfaces

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CS35023H

Targeting protein-protein interactions for therapeutic intervention: a challenge for the future.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CS35023H

A small molecule that binds Hedgehog and blocks its signaling in human cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CS35023H

Small-molecule inhibitors of the hedgehog signaling pathway as cancer therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CS35023H

Syntheses of aminoalcohol-derived macrocycles leading to a small-molecule binder to and inhibitor of Sonic Hedgehog

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CS35023H

Mechanisms of antileukemic activity of the novel Bcl-2 homology domain-3 mimetic GX15-070 (obatoclax).

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CS35023H

The Bcl-2 protein family: arbiters of cell survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CS35023H

Diversity-oriented synthesis of a cytisine-inspired pyridone library leading to the discovery of novel inhibitors of Bcl-2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CS35023H

Identification of lead compounds as antagonists of protein Bcl-xL with a diversity-oriented multidisciplinary approach

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CS35023H

The DNA damage response: putting checkpoints in perspective

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CS35023H

Targeting the checkpoint kinases: chemosensitization versus chemoprotection

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CS35023H

Chemical methodology as a source of small-molecule checkpoint inhibitors and heat shock protein 70 (Hsp70) modulators

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CS35023H

Antibiotic resistance is ancient

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CS35023H

Antibacterial discovery and development--the failure of success?

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CS35023H

Expanding the range of 'druggable' targets with natural product-based libraries: an academic perspective

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CS35023H

Antibiotics for emerging pathogens

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CS35023H

Drugs for bad bugs: confronting the challenges of antibacterial discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CS35023H

The discovery of antibacterial agents using diversity-oriented synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CS35023H

Gemmacin B: bringing diversity back into focus

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CS35023H

Identification of an anti-MRSA dihydrofolate reductase inhibitor from a diversity-oriented synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CS35023H

Anticancer activities of histone deacetylase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CS35023H

Discovery, biological activity, synthesis and potential therapeutic utility of naturally occurring histone deacetylase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CS35023H

Histone deacetylase inhibitors and the promise of epigenetic (and more) treatments for cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CS35023H

An Aldol-Based Build/Couple/Pair Strategy for the Synthesis of Medium- and Large-Sized Rings: Discovery of Macrocyclic Histone Deacetylase Inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CS35023H

A design strategy for drug-like polyheterocycles with privileged substructures for discovery of specific small-molecule modulators

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CS35023H

Biology-inspired synthesis of compound libraries

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CS35023H

Biology-oriented synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CS35023H

Development of a benzopyran-containing androgen receptor antagonist to treat antiandrogen-resistant prostate cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CS35023H

Antidiabetic and antiobesity effects of Ampkinone (6f), a novel small molecule activator of AMP-activated protein kinase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CS35023H

Discovery of novel benzopyranyl tetracycles that act as inhibitors of osteoclastogenesis induced by receptor activator of NF-κB ligand

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CS35023H

Generation of anti-trypanosomal agents through concise synthesis and structural diversification of sesquiterpene analogues

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CS35023H

Protein structure similarity clustering and natural product structure as guiding principles in drug discovery.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CS35023H

Biology-oriented synthesis of a natural-product inspired oxepane collection yields a small-molecule activator of the Wnt-pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CS35023H

Bioactivity-guided mapping and navigation of chemical space.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CS35023H

Highly enantioselective synthesis and cellular evaluation of spirooxindoles inspired by natural products

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CS35023H

Spirodiepoxide-based cascades: direct access to diverse motifs

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CS35023H

Diversity-oriented synthesis leads to an effective class of bifunctional linchpins uniting anion relay chemistry (ARC) with benzyne reactivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CS35023H

Remodelling of the natural product fumagillol employing a reaction discovery approach

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CS35023H

Route to three-dimensional fragments using diversity-oriented synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CS35023H

Diversity-oriented synthesis; a challenge for synthetic chemistsElectronic supplementary information (ESI) available: Excel file of all the FDA new molecular entities between the years 1998 and July 2003, and new drug approvals between the years 1990

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CS35023H

Skeletal diversity construction via a branching synthetic strategy

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CS35023H

The State of the Art of Chemical Biology

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CS35023H

21 January 2018

Identifiers

DOI

10.1039/C2CS35023H

1 reference

31 July 2017

1 reference