Route to three-dimensional fragments using diversity-oriented synthesis (Q33868796)

29 July 2017

title

Route to three-dimensional fragments using diversity-oriented synthesis (English)

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29 July 2017

Alvin W Hung

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29 July 2017

Alex Ramek

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29 July 2017

Yikai Wang

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29 July 2017

Taner Kaya

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29 July 2017

J Anthony Wilson

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29 July 2017

Paul A Clemons

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29 July 2017

Damian W Young

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29 July 2017

language of work or name

English

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publication date

11 April 2011

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Proceedings of the National Academy of Sciences of the United States of America

29 July 2017

published in

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29 July 2017

volume

108

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29 July 2017

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29 July 2017

page(s)

6799-6804

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The rise of fragment-based drug discovery

29 July 2017

cites work

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An Aldol-Based Build/Couple/Pair Strategy for the Synthesis of Medium- and Large-Sized Rings: Discovery of Macrocyclic Histone Deacetylase Inhibitors

28 July 2018

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Small molecules of different origins have distinct distributions of structural complexity that correlate with protein-binding profiles

28 July 2018

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Diversity-oriented synthesis as a tool for the discovery of novel biologically active small molecules

28 July 2018

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Drugging challenging targets using fragment-based approaches

28 July 2018

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Application of fragment growing and fragment linking to the discovery of inhibitors of Mycobacterium tuberculosis pantothenate synthetase

28 July 2018

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From fragment to clinical candidate--a historical perspective.

28 July 2018

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Towards the optimal screening collection: a synthesis strategy

28 July 2018

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Fragment-based approaches to enzyme inhibition

28 July 2018

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A decade of fragment-based drug design: strategic advances and lessons learned

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Drugs for bad bugs: confronting the challenges of antibacterial discovery

28 July 2018

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Small molecules: the missing link in the central dogma

28 July 2018

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Fragment-based lead discovery: leads by design

28 July 2018

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Self-selection in olefin cross-metathesis: the effect of remote functionality

28 July 2018

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ZINC--a free database of commercially available compounds for virtual screening

28 July 2018

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Exploring biology with small organic molecules

28 July 2018

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A planning strategy for diversity-oriented synthesis

28 July 2018

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A ‘Rule of Three’ for fragment-based lead discovery?

28 July 2018

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Molecular shape diversity of combinatorial libraries: a prerequisite for broad bioactivity.

28 July 2018

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High-throughput crystallography for lead discovery in drug design.

28 July 2018

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Target-oriented and diversity-oriented organic synthesis in drug discovery

28 July 2018

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Recent developments in fragment-based drug discovery

28 July 2018

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https://api.crossref.org/works/10.1073%2FPNAS.1015271108

A small molecule that binds Hedgehog and blocks its signaling in human cells

21 January 2018

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https://api.crossref.org/works/10.1073%2FPNAS.1015271108

Oxyma: an efficient additive for peptide synthesis to replace the benzotriazole-based HOBt and HOAt with a lower risk of explosion.

21 January 2018

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Synthesis of sultam scaffolds via intramolecular oxa-Michael and diastereoselective Baylis-Hillman reactions

21 January 2018

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Decomposition of a key intermediate in ruthenium-catalyzed olefin metathesis reactions.

21 January 2018

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Escape from flatland: increasing saturation as an approach to improving clinical success

21 January 2018

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The impact of aromatic ring count on compound developability--are too many aromatic rings a liability in drug design?

21 January 2018

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Drug discovery: A question of library design

21 January 2018

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Molecular diversity by design

21 January 2018

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Rational Molecular Design and EPC Synthesis of a Type VI beta-Turn Inducing Peptide Mimetic This work was supported by the BMBF and the Fonds der Chemischen Industrie. EPC=enantiomerically pure compound

21 January 2018

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12 December 2020

Synthesis of Cyclic Proline-Containing Peptides via Ring-Closing Metathesis

1 reference

12 December 2020

An Oligomer-Based Approach to Skeletal Diversity in Small-Molecule Synthesis

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12 December 2020

Synthesis of macrocyclic analogues of the neuroprotective agent glycyl-l-prolyl-l-glutamic acid (GPE)

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12 December 2020

Identifiers

DOI

10.1073/PNAS.1015271108

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29 July 2017

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29 July 2017

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