Gliomagenesis: genetic alterations and mouse models (Q34186001)

31 July 2017

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title

Gliomagenesis: genetic alterations and mouse models (English)

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31 July 2017

Holland EC

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31 July 2017

publication date

1 February 2001

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31 July 2017

published in

Nature Reviews Genetics

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31 July 2017

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31 July 2017

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31 July 2017

page(s)

120-129

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Growth factor-mediated angiogenesis in the malignant progression of glial tumors: a review

31 July 2017

cites work

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7 January 2021

Mammalian neural stem cells

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7 January 2021

Gliogenesis in the central nervous system

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7 January 2021

Purification and characterization of astrocyte precursor cells in the developing rat optic nerve

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7 January 2021

Regulation of neurogenesis by growth factors and neurotransmitters

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FGF modulates the PDGF-driven pathway of oligodendrocyte development.

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7 January 2021

The inhibition of oligodendrocytic differentiation of O-2A progenitors caused by basic fibroblast growth factor is overridden by astrocytes

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7 January 2021

Cooperation between two growth factors promotes extended self-renewal and inhibits differentiation of oligodendrocyte-type-2 astrocyte (O-2A) progenitor cells

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7 January 2021

Multiple routes to astrocytic differentiation in the CNS.

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7 January 2021

Growth factors, glia and gliomas

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7 January 2021

Correlation of basic fibroblast growth factor expression levels with the degree of malignancy and vascularity in human gliomas

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7 January 2021

CNTF and its receptor subunits in human gliomas.

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7 January 2021

Expression of PDGF and PDGF receptors in human astrocytoma operation specimens supports the existence of an autocrine loop.

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7 January 2021

Structural alterations of the epidermal growth factor receptor gene in human gliomas

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7 January 2021

Protein kinases and phosphatases: the yin and yang of protein phosphorylation and signaling

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7 January 2021

The catalytic domain of the neurofibromatosis type 1 gene product stimulates ras GTPase and complements ira mutants of S. cerevisiae

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7 January 2021

Proliferation of human malignant astrocytomas is dependent on Ras activation

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7 January 2021

Myogenic signaling of phosphatidylinositol 3-kinase requires the serine-threonine kinase Akt/protein kinase B.

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7 January 2021

TOR signalling and control of cell growth

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7 January 2021

Acquisition of the glioblastoma phenotype during astrocytoma progression is associated with loss of heterozygosity on 10q25-qter

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7 January 2021

Combined activation of Ras and Akt in neural progenitors induces glioblastoma formation in mice

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7 January 2021

A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4

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7 January 2021

Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF

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7 January 2021

The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53

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7 January 2021

Splicing into Senescence: The Curious Case of p16 and p19ARF

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7 January 2021

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7 January 2021

Role of the p16 tumor suppressor gene in cancer

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7 January 2021

p53 gene mutation and ink4a-arf deletion appear to be two mutually exclusive events in human glioblastoma.

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7 January 2021

Analysis of glioma cell lines for amplification and overexpression of MDM2.

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7 January 2021

Subsets of glioblastoma multiforme defined by molecular genetic analysis

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7 January 2021

p53 mutation, expression, and DNA ploidy in evolving gliomas: evidence for two pathways of progression.

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7 January 2021

Overexpression of the EGF receptor and p53 mutations are mutually exclusive in the evolution of primary and secondary glioblastomas

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7 January 2021

PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer

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7 January 2021

Opposite functions for E2F1 and E2F4 in human epidermal keratinocyte differentiation

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7 January 2021

Retrodifferentiation and cell death.

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7 January 2021

Differentiation of the immortalized adult neuronal progenitor cell line HC2S2 into neurons by regulatable suppression of the v-myc oncogene

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7 January 2021

Exploitation of immune mechanisms in the treatment of central nervous system cancer

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7 January 2021

Transgenic and gene disruption techniques in the study of neurocarcinogenesis

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7 January 2021

Insights into cancer from transgenic mouse models

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7 January 2021

Development of a flexible and specific gene delivery system for production of murine tumor models

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7 January 2021

Astrocytes give rise to oligodendrogliomas and astrocytomas after gene transfer of polyoma virus middle T antigen in vivo

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7 January 2021

Essential role for oncogenic Ras in tumour maintenance

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7 January 2021

Reversible tumorigenesis by MYC in hematopoietic lineages

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7 January 2021

Reversible activation of c-Myc in skin: induction of a complex neoplastic phenotype by a single oncogenic lesion

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7 January 2021

Development and malignant progression of astrocytomas in GFAP-v-src transgenic mice

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7 January 2021

Nf1;Trp53 mutant mice develop glioblastoma with evidence of strain-specific effects

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7 January 2021

Role of the INK4a locus in tumor suppression and cell mortality.

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7 January 2021

Modeling mutations in the G1 arrest pathway in human gliomas: overexpression of CDK4 but not loss of INK4a-ARF induces hyperploidy in cultured mouse astrocytes

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7 January 2021

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

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7 January 2021

Astrocytes derived from p53-deficient mice provide a multistep in vitro model for development of malignant gliomas

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7 January 2021

Effects of an Rb mutation in the mouse

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7 January 2021

A constitutively active epidermal growth factor receptor cooperates with disruption of G1 cell-cycle arrest pathways to induce glioma-like lesions in mice

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7 January 2021

Identifiers

DOI

10.1038/35052535

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Dimensions Publication ID

31 July 2017

1036220926

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