Gene directed enzyme/prodrug therapy of cancer: historical appraisal and future prospectives (Q34176439)

31 July 2017

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title

Gene directed enzyme/prodrug therapy of cancer: historical appraisal and future prospectives (English)

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31 July 2017

Greco O

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31 July 2017

Dachs GU

series ordinal

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31 July 2017

publication date

1 April 2001

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Journal of Cellular Physiology

31 July 2017

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inferred from page(s)

published in

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31 July 2017

volume

187

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31 July 2017

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31 July 2017

page(s)

22-36

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Experimental gene therapy for brain tumors using adenovirus-mediated transfer of cytosine deaminase gene and uracil phosphoribosyltransferase gene with 5-fluorocytosine

31 July 2017

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21 January 2018

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Cytotoxicity of adenoviral-mediated cytosine deaminase plus 5-fluorocytosine gene therapy is superior to thymidine kinase plus acyclovir in a human renal cell carcinoma model

21 January 2018

1 reference

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Gene delivery to glioma cells in rat brain by grafting of a retrovirus packaging cell line

21 January 2018

1 reference

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Treatment of experimental human mesothelioma using adenovirus transfer of the herpes simplex thymidine kinase gene

21 January 2018

1 reference

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Fractionated radiation therapy in combination with adenoviral delivery of the cytosine deaminase gene and 5-fluorocytosine enhances cytotoxic and antitumor effects in human colorectal and cholangiocarcinoma models

21 January 2018

1 reference

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Gene therapy for glioblastoma [correction of gliobestome] multiform: in vivo tumor transduction with the herpes simplex thymidine kinase gene followed by ganciclovir

21 January 2018

1 reference

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Regressions of established breast carcinoma xenografts by carboxypeptidase G2 suicide gene therapy and the prodrug CMDA are due to a bystander effect

21 January 2018

1 reference

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Comparison of the genotoxic and apoptosis-inducing properties of ganciclovir and penciclovir in Chinese hamster ovary cells transfected with the thymidine kinase gene of herpes simplex virus-1: implications for gene therapeutic approaches

21 January 2018

1 reference

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Regional 'pro-drug' gene therapy: intravenous administration of an adenoviral vector expressing the E. coli cytosine deaminase gene and systemic administration of 5-fluorocytosine suppresses growth of hepatic metastasis of colon carcinoma

21 January 2018

1 reference

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Enhancement of the herpes simplex virus thymidine kinase/ganciclovir bystander effect and its antitumor efficacy in vivo by pharmacologic manipulation of gap junctions

21 January 2018

1 reference

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Double suicide gene (cytosine deaminase and herpes simplex virus thymidine kinase) but not single gene transfer allows reliable elimination of tumor cells in vivo

21 January 2018

1 reference

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Generation of an anti-tumour immune response in a non-immunogenic tumour: HSVtk killing in vivo stimulates a mononuclear cell infiltrate and a Th1-like profile of intratumoural cytokine expression

21 January 2018

1 reference

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Sensitisation of human carcinoma cells to the prodrug CB1954 by adenovirus vector-mediated expression of E. coli nitroreductase.

21 January 2018

1 reference

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Experimental tumor therapy in mice using the cyclophosphamide-activating cytochrome P450 2B1 gene

21 January 2018

1 reference

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Involvement of Fas (CD95/APO-1) and Fas ligand in apoptosis induced by ganciclovir treatment of tumor cells transduced with herpes simplex virus thymidine kinase

21 January 2018

1 reference

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The nitroreductase/CB1954 combination in Epstein-Barr virus-positive B-cell lines: induction of bystander killing in vitro and in vivo

21 January 2018

1 reference

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HSV-tk gene therapy in head and neck squamous cell carcinoma. Enhancement by the local and distant bystander effect

21 January 2018

1 reference

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The nitroreductase enzyme in walker cells that activates 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB 1954) to 5-(aziridin-1-YL)-4-hydroxylamino-2-nitrobenzamide is a form of NAD(P)H dehydrogenase (quinone) (EC 1.6.99.2)

21 January 2018

1 reference

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Targeting gene expression to hypoxic tumor cells

21 January 2018

1 reference

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A Phase I/II Study of Herpes Simplex Virus Type 1 Thymidine Kinase “Suicide” Gene Therapy for Recurrent Glioblastoma

21 January 2018

1 reference

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Activation of the anti-cancer drug ifosphamide by rat liver microsomal P450 enzymes

21 January 2018

1 reference

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Cure of Mice bearing Advanced Plasma Cell Tumours with Aniline Mustard : the Relationship between Glucuronidase Activity and Tumour Sensitivity

21 January 2018

1 reference

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Gap junctions: the "kiss of death" and the "kiss of life"

21 January 2018

1 reference

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Phase I study of direct administration of a replication deficient adenovirus vector containing the E. coli cytosine deaminase gene to metastatic colon carcinoma of the liver in association with the oral administration of the pro-drug 5-fluorocytosine

21 January 2018

1 reference

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Expression of Escherichia coli B nitroreductase in established human tumor xenografts in mice results in potent antitumoral and bystander effects upon systemic administration of the prodrug CB1954

21 January 2018

1 reference

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Transport of 5-fluorouracil and uracil into human erythrocytes

21 January 2018

1 reference

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The treatment of ovarian cancer with a gene modified cancer vaccine: a phase I study

21 January 2018

1 reference

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Combined radiation and enzyme/prodrug treatment for head and neck cancer in an orthotopic animal model

21 January 2018

1 reference

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A new cytotoxic, DNA interstrand crosslinking agent, 5-(aziridin-1-yl)-4-hydroxylamino-2-nitrobenzamide, is formed from 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB 1954) by a nitroreductase enzyme in Walker carcinoma cells

21 January 2018

1 reference

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The bioactivation of 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB1954)--II. A comparison of an Escherichia coli nitroreductase and Walker DT diaphorase

21 January 2018

1 reference

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Antibody-directed enzyme prodrug therapy: pharmacokinetics and plasma levels of prodrug and drug in a phase I clinical trial

21 January 2018

1 reference

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Hypoglycemic action of indole-3-acetic acid by mouth in patients with diabetes mellitus.

21 January 2018

1 reference

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The immune response elicited by mammary adenocarcinoma cells transduced with interferon-gamma and cytosine deaminase genes cures lung metastases by parental cells

21 January 2018

1 reference

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Peroxidase activity may play a role in the cytotoxic effect of indole acetic acid

21 January 2018

1 reference

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Novel prodrugs which are activated to cytotoxic alkylating agents by carboxypeptidase G2

21 January 2018

1 reference

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Analysis of antibody-enzyme conjugate clearance by investigation of prodrug and active drug in an ADEPT clinical study

21 January 2018

1 reference

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10.1002/1097-4652(2001)9999:9999<::AID-JCP1060>3.0.CO;2-H

21 January 2018

Identifiers

DOI

1 reference

31 July 2017

1 reference