Regulators of G-protein signalling as new central nervous system drug targets. (Q34139169)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12120503%20AND%20SRC:MED&resulttype=core&format=json

11 November 2019

review article

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title

Regulators of G-protein signalling as new central nervous system drug targets (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12120503%20AND%20SRC:MED&resulttype=core&format=json

11 November 2019

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12120503%20AND%20SRC:MED&resulttype=core&format=json

11 November 2019

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12120503%20AND%20SRC:MED&resulttype=core&format=json

11 November 2019

Richard R Neubig

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31 July 2017

David P Siderovski

series ordinal

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31 July 2017

publication date

1 March 2002

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12120503%20AND%20SRC:MED&resulttype=core&format=json

Nature Reviews Drug Discovery

11 November 2019

published in

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11 November 2019

volume

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11 November 2019

issue

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11 November 2019

page(s)

187-197

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G proteins: transducers of receptor-generated signals

11 November 2019

cites work

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A point mutation in Galphao and Galphai1 blocks interaction with regulator of G protein signaling proteins

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Endogenous regulator of G-protein signaling proteins modify N-type calcium channel modulation in rat sympathetic neurons

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The N-terminal domain of RGS4 confers receptor-selective inhibition of G protein signaling

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Dynamic Regulation of RGS2 Suggests a Novel Mechanism in G-Protein Signaling and Neuronal Plasticity

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Disease-specific changes in regulator of G-protein signaling 4 (RGS4) expression in schizophrenia

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Chronic treatment with certain antipsychotic drugs preserves upregulation of regulator of G-protein signalling 2 mRNA in rat striatum as opposed to c-fos mRNA.

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Regulators of G protein signaling: rapid changes in mRNA abundance in response to amphetamine.

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Regulation of T cell activation, anxiety, and male aggression by RGS2.

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Slowed recovery of rod photoresponse in mice lacking the GTPase accelerating protein RGS9-1.

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Elevated levels of DeltaFosB and RGS9 in striatum in Parkinson's disease

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Solution structure of human GAIP (Galpha interacting protein): a regulator of G protein signaling

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NMR structure of free RGS4 reveals an induced conformational change upon binding Galpha

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Structural determinants for regulation of phosphodiesterase by a G protein at 2.0 A

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Structure of the RGS-like Domain from PDZ-RhoGEF

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Structure of the rgRGS domain of p115RhoGEF

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Structural basis of the Axin-adenomatous polyposis coli interaction

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Ca2+/Calmodulin reverses phosphatidylinositol 3,4, 5-trisphosphate-dependent inhibition of regulators of G protein-signaling GTPase-activating protein activity

31 March 2020

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Ca(2+) elevation evoked by membrane depolarization regulates G protein cycle via RGS proteins in the heart

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RGS12 and RGS14 GoLoco motifs are G alpha(i) interaction sites with guanine nucleotide dissociation inhibitor Activity

31 March 2020

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Structure-based design of an osteoclast-selective, nonpeptide src homology 2 inhibitor with in vivo antiresorptive activity

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Mu-opioid receptor desensitization by beta-arrestin-2 determines morphine tolerance but not dependence

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Divergence of RGS proteins: evidence for the existence of six mammalian RGS subfamilies

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GAIP is membrane-anchored by palmitoylation and interacts with the activated (GTP-bound) form of G alpha i subunits

31 March 2020

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A G protein gamma subunit-like domain shared between RGS11 and other RGS proteins specifies binding to Gbeta5 subunits

31 March 2020

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Selective regulation of Galpha(q/11) by an RGS domain in the G protein-coupled receptor kinase, GRK2

31 March 2020

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RGS-PX1, a GAP for GalphaS and sorting nexin in vesicular trafficking

31 March 2020

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Cloning and mitochondrial localization of full-length D-AKAP2, a protein kinase A anchoring protein

31 March 2020

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The scopolamine-induced impairment of spatial cognition parallels the acetylcholine release in the ventral hippocampus in rats.

31 March 2020

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Cholinergic excitation of septohippocampal GABA but not cholinergic neurons: implications for learning and memory.

31 March 2020

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RGS4 and GAIP are GTPase-activating proteins for Gq alpha and block activation of phospholipase C beta by gamma-thio-GTP-Gq alpha

31 March 2020

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Modulation of rap activity by direct interaction of Galpha(o) with Rap1 GTPase-activating protein.

31 March 2020

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31 March 2020

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RGSZ1, a Gz-selective regulator of G protein signaling whose action is sensitive to the phosphorylation state of Gzalpha

31 March 2020

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The GTPase-activating protein RGS4 stabilizes the transition state for nucleotide hydrolysis

31 March 2020

1 reference

RGS3 is a GTPase-activating protein for g(ialpha) and g(qalpha) and a potent inhibitor of signaling by GTPase-deficient forms of g(qalpha) and g(11alpha)

31 March 2020

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Characterization of RGS5 in regulation of G protein-coupled receptor signaling

31 March 2020

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RGS8 accelerates G-protein-mediated modulation of K+currents

31 March 2020

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Amino-terminal cysteine residues of RGS16 are required for palmitoylation and modulation of Gi- and Gq-mediated signaling

31 March 2020

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Molecular cloning and characterization of a novel regulator of G-protein signaling from mouse hematopoietic stem cells

31 March 2020

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Regulators of G protein signaling 6 and 7. Purification of complexes with gbeta5 and assessment of their effects on g protein-mediated signaling pathways

31 March 2020

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Rapid kinetics of regulator of G-protein signaling (RGS)-mediated Galphai and Galphao deactivation. Galpha specificity of RGS4 AND RGS7

31 March 2020

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RGS14 is a bifunctional regulator of Galphai/o activity that exists in multiple populations in brain

31 March 2020

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Leukemia-associated Rho guanine nucleotide exchange factor (LARG) links heterotrimeric G proteins of the G(12) family to Rho

31 March 2020

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Regional distribution of regulators of G-protein signaling (RGS) 1, 2, 13, 14, 16, and GAIP messenger ribonucleic acids by in situ hybridization in rat brain

31 March 2020

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Altered gene expression in cerebral capillaries of stroke-prone spontaneously hypertensive rats

31 March 2020

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Upregulation of RGS7 may contribute to tumor necrosis factor-induced changes in central nervous function

31 March 2020

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