Poly(ADP-ribose) polymerase inhibitor induces accelerated senescence in irradiated breast cancer cells and tumors (Q34031756)

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7 February 2020

title

Poly(ADP-ribose) polymerase inhibitor induces accelerated senescence in irradiated breast cancer cells and tumors (English)

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7 February 2020

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ChEBI release 2020-05-28

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7 February 2020

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7 February 2020

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7 February 2020

Ralph R Weichselbaum

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7 February 2020

Helena J Mauceri

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7 February 2020

Elena V Efimova

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7 February 2020

Edwardine Labay

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7 February 2020

Vytautas P Bindokas

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7 February 2020

Chaitali Chakraborty

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7 February 2020

Juan Camilo Barreto-Andrade

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7 February 2020

Clayton Crawley

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7 February 2020

Harold G Sutton

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7 February 2020

language of work or name

English

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publication date

7 July 2010

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7 February 2020

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7 February 2020

volume

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7 February 2020

issue

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7 February 2020

page(s)

6277-6282

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Synthetic lethal targeting of PTEN mutant cells with PARP inhibitors

7 February 2020

cites work

1 reference

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Senescence in tumours: evidence from mice and humans

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2912962

Targeting the DNA damage response in cancer

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2912962

Crosstalk between histone modifications during the DNA damage response.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2912962

Senescence induction; a possible cancer therapy

5 July 2018

1 reference

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5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2912962

Proteome-wide identification of poly(ADP-ribose) binding proteins and poly(ADP-ribose)-associated protein complexes

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2912962

Potentiation of temozolomide cytotoxicity by poly(ADP)ribose polymerase inhibitor ABT-888 requires a conversion of single-stranded DNA damages to double-stranded DNA breaks.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2912962

Accelerated senescence: an emerging role in tumor cell response to chemotherapy and radiation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2912962

Living on a break: cellular senescence as a DNA-damage response

5 July 2018

1 reference

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Cellular senescence: when bad things happen to good cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2912962

Inhibition of poly(ADP-ribose) polymerase enhances cell death and improves tumor growth delay in irradiated lung cancer models

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2912962

ABT-888, an orally active poly(ADP-ribose) polymerase inhibitor that potentiates DNA-damaging agents in preclinical tumor models

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2912962

Poly(ADP-ribose): novel functions for an old molecule

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2912962

Methylated lysine 79 of histone H3 targets 53BP1 to DNA double-strand breaks

5 July 2018

1 reference

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Tumor cell senescence in cancer treatment

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2912962

Transient poly(ADP-ribosyl)ation of nuclear proteins and role of poly(ADP-ribose) polymerase in the early stages of apoptosis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2912962

New functions for an ancient domain

5 July 2018

1 reference

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Discovery of the Poly(ADP-ribose) polymerase (PARP) inhibitor 2-[(R)-2-methylpyrrolidin-2-yl]-1H-benzimidazole-4-carboxamide (ABT-888) for the treatment of cancer

29 October 2018

1 reference

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Growth of persistent foci of DNA damage checkpoint factors is essential for amplification of G1 checkpoint signaling

29 October 2018

1 reference

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53BP1 exchanges slowly at the sites of DNA damage and appears to require RNA for its association with chromatin.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2912962

Enhanced radiation-induced cell killing and prolongation of gammaH2AX foci expression by the histone deacetylase inhibitor MS-275.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2912962

A senescence-like phenotype distinguishes tumor cells that undergo terminal proliferation arrest after exposure to anticancer agents

29 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20610628

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Development of PARP inhibitors in oncology

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20610628

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1158/0008-5472.CAN-09-4224

1 reference

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7 February 2020

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7 February 2020

PubMed publication ID

20610628

1 reference

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