Hypoxia inducible factor 1, alpha subunit (Q21981069)

PAS domain superfamily

1 reference

Helix-loop-helix DNA-binding domain superfamily

1 reference

Myc-type, basic helix-loop-helix (bHLH) domain, protein family

1 reference

HIF-1 alpha, transactivation domain, C-terminal domain, protein family

1 reference

PAS fold family

1 reference

PAS fold-3 domain, protein family

1 reference

PAC motif domain, protein family

1 reference

PAS domain, protein family

1 reference

protein dimerization activity

1 reference

25 May 2022

1 reference

25 May 2022

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61221

1 reference

9 May 2019

DNA-binding transcription factor activity

Differential activities of murine single minded 1 (SIM1) and SIM2 on a hypoxic response element. Cross-talk between basic helix-loop-helix/per-Arnt-Sim homology transcription factors

4 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61221

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61221

9 May 2019

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61221

9 May 2019

Vhlh gene deletion induces Hif-1-mediated cell death in thymocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61221

DNA-binding transcription activator activity, RNA polymerase II-specific

1 reference

10 September 2018

The survival effect of mitochondrial Higd-1a is associated with suppression of cytochrome C release and prevention of caspase activation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61221&geneProductId=UniProtKB:Q61221

histone deacetylase binding

1 reference

9 May 2019

Transcriptional activation of hypoxia-inducible factor-1alpha by HDAC4 and HDAC5 involves differential recruitment of p300 and FIH-1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61221

protein binding

7 references

9 May 2019

Pro-apoptotic activity of inhibitory PAS domain protein (IPAS), a negative regulator of HIF-1, through binding to pro-survival Bcl-2 family proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61221

9 May 2019

Induction of phosphoglycerate kinase 1 gene expression by hypoxia. Roles of Arnt and HIF1alpha

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61221

9 May 2019

Increased activity of hypoxia-inducible factor 1 is associated with early embryonic lethality in Commd1 null mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61221

9 May 2019

Hypoxia-inducible factor-1alpha regulates beta cell function in mouse and human islets

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61221

9 May 2019

Control of T(H)17/T(reg) balance by hypoxia-inducible factor 1

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61221

9 May 2019

Siah2-dependent concerted activity of HIF and FoxA2 regulates formation of neuroendocrine phenotype and neuroendocrine prostate tumors

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61221

9 May 2019

HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61221

histone acetyltransferase binding

A novel bHLH-PAS factor with close sequence similarity to hypoxia-inducible factor 1alpha regulates the VEGF expression and is potentially involved in lung and vascular development

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61221

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61221

9 May 2019

9 May 2019

Vhlh gene deletion induces Hif-1-mediated cell death in thymocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61221

sequence-specific DNA binding

5 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61221

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61221

9 May 2019

Structural integration in hypoxia-inducible factors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61221

9 May 2019

Molecular characterization of the murine Hif-1 alpha locus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61221

9 May 2019

Advanced glycated end-products affect HIF-transcriptional activity in renal cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61221

protein heterodimerization activity

3 references

1 reference

9 May 2019

The hypoxia-inducible microRNA cluster miR-199a∼214 targets myocardial PPARδ and impairs mitochondrial fatty acid oxidation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61221

DNA-binding transcription factor activity, RNA polymerase II-specific

3 references

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61221&geneProductId=UniProtKB:Q61221

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61221&geneProductId=UniProtKB:Q61221

21 June 2018

Advanced glycated end-products affect HIF-transcriptional activity in renal cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61221&geneProductId=UniProtKB:Q61221

protein-containing complex binding

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61221

protein heterodimerization activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61221

4 references

9 May 2019

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61221

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61221

9 May 2019

Structural integration in hypoxia-inducible factors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61221

DNA-binding transcription factor activity, RNA polymerase II-specific

DNA-binding transcription factor activity, RNA polymerase II-specific

4 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61221

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61221

9 May 2019

Advanced glycated end-products affect HIF-transcriptional activity in renal cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61221

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61221

DNA-binding transcription activator activity, RNA polymerase II-specific

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61221

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61221

9 May 2019

The survival effect of mitochondrial Higd-1a is associated with suppression of cytochrome C release and prevention of caspase activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61221

RNA polymerase II transcription regulatory region sequence-specific DNA binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61221

cell component

cytoplasm

cytosol

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61221&geneProductId=UniProtKB:Q61221

14 references

16 July 2018

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61221&geneProductId=UniProtKB:Q61221

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61221&geneProductId=UniProtKB:Q61221

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61221&geneProductId=UniProtKB:Q61221

16 July 2018

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61221&geneProductId=UniProtKB:Q61221

16 July 2018

Pro-apoptotic activity of inhibitory PAS domain protein (IPAS), a negative regulator of HIF-1, through binding to pro-survival Bcl-2 family proteins

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61221&geneProductId=UniProtKB:Q61221

16 July 2018

Metallothionein-III induces HIF-1alpha-mediated VEGF expression in brain endothelial cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61221&geneProductId=UniProtKB:Q61221

16 July 2018

Loss of PINK1 attenuates HIF-1α induction by preventing 4E-BP1-dependent switch in protein translation under hypoxia

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61221&geneProductId=UniProtKB:Q61221

16 July 2018

Hypoxia-inducible factor-1alpha regulates beta cell function in mouse and human islets

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61221&geneProductId=UniProtKB:Q61221

16 July 2018

Superoxide dismutase-3 promotes full expression of the EPO response to hypoxia

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61221&geneProductId=UniProtKB:Q61221

16 July 2018

RSUME is implicated in HIF-1-induced VEGF-A production in pituitary tumour cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61221&geneProductId=UniProtKB:Q61221

16 July 2018

Vhlh gene deletion induces Hif-1-mediated cell death in thymocytes

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61221&geneProductId=UniProtKB:Q61221

16 July 2018

Advanced glycated end-products affect HIF-transcriptional activity in renal cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61221&geneProductId=UniProtKB:Q61221

16 July 2018

Hypoxia in cartilage: HIF-1alpha is essential for chondrocyte growth arrest and survival

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61221&geneProductId=UniProtKB:Q61221

motile cilium

1 reference

9 May 2019

Isoform-specific expression of hypoxia-inducible factor-1alpha during the late stages of mouse spermiogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61221

axon cytoplasm

1 reference

9 May 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61221

nucleus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61221

15 references

9 May 2019

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61221

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61221

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61221

9 May 2019

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61221

9 May 2019

Metallothionein-III induces HIF-1alpha-mediated VEGF expression in brain endothelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61221

9 May 2019

Pro-apoptotic activity of inhibitory PAS domain protein (IPAS), a negative regulator of HIF-1, through binding to pro-survival Bcl-2 family proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61221

9 May 2019

Loss of PINK1 attenuates HIF-1α induction by preventing 4E-BP1-dependent switch in protein translation under hypoxia

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61221

9 May 2019

RSUME is implicated in HIF-1-induced VEGF-A production in pituitary tumour cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61221

9 May 2019

Hypoxia-inducible factor-1alpha regulates beta cell function in mouse and human islets

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61221

9 May 2019

Superoxide dismutase-3 promotes full expression of the EPO response to hypoxia

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61221

9 May 2019

Advanced glycated end-products affect HIF-transcriptional activity in renal cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61221

9 May 2019

Vhlh gene deletion induces Hif-1-mediated cell death in thymocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61221

9 May 2019

Hypoxia in cartilage: HIF-1alpha is essential for chondrocyte growth arrest and survival

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61221

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61221

negative regulation of neuron apoptotic process

biological process

1 reference

9 May 2019

Defective brain development in mice lacking the Hif-1alpha gene in neural cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61221

B-1 B cell homeostasis

1 reference

9 May 2019

Abnormal B lymphocyte development and autoimmunity in hypoxia-inducible factor 1alpha -deficient chimeric mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61221

muscle cell cellular homeostasis

1 reference

9 May 2019

Loss of skeletal muscle HIF-1alpha results in altered exercise endurance

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61221

outflow tract morphogenesis

1 reference

9 May 2019

Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1 alpha

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61221

negative regulation of ossification

1 reference

9 May 2019

Hypoxia-inducible factor-1α protein negatively regulates load-induced bone formation

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61221

heart looping

1 reference

9 May 2019

Cardia bifida, defective heart development and abnormal neural crest migration in embryos lacking hypoxia-inducible factor-1alpha

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61221

negative regulation of TOR signaling

1 reference

9 May 2019

Loss of hepatocyte-nuclear-factor-1alpha impacts on adult mouse intestinal epithelial cell growth and cell lineages differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61221

blood vessel development

1 reference

9 May 2019

Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1 alpha

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61221

hemoglobin biosynthetic process

1 reference

9 May 2019

Hypoxia-inducible factor-1 deficiency results in dysregulated erythropoiesis signaling and iron homeostasis in mouse development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61221

positive regulation of insulin secretion involved in cellular response to glucose stimulus

1 reference

9 May 2019

Hypoxia-inducible factor-1alpha regulates beta cell function in mouse and human islets

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61221

cellular response to hypoxia

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61221

4 references

9 May 2019

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61221

9 May 2019

The hypoxia-inducible microRNA cluster miR-199a∼214 targets myocardial PPARδ and impairs mitochondrial fatty acid oxidation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61221

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61221

negative regulation of mesenchymal cell apoptotic process

1 reference

9 May 2019

Defective vascularization of HIF-1alpha-null embryos is not associated with VEGF deficiency but with mesenchymal cell death

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61221

regulation of aerobic respiration

1 reference

9 May 2019

Mitochondrial autophagy is an HIF-1-dependent adaptive metabolic response to hypoxia

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61221

positive regulation of neuroblast proliferation

1 reference

9 May 2019

Lack of hypoxia-inducible factor-1 alpha impairs midbrain neural precursor cells involving vascular endothelial growth factor signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61221

dopaminergic neuron differentiation

lactate metabolic process

2 references

1 reference

9 May 2019

Loss of skeletal muscle HIF-1alpha results in altered exercise endurance

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61221

regulation of transcription, DNA-templated

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61221

5 references

9 May 2019

9 May 2019

Differential activities of murine single minded 1 (SIM1) and SIM2 on a hypoxic response element. Cross-talk between basic helix-loop-helix/per-Arnt-Sim homology transcription factors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61221

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61221

9 May 2019

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61221

9 May 2019

Vhlh gene deletion induces Hif-1-mediated cell death in thymocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61221

blood vessel morphogenesis

1 reference

9 May 2019

HIF-1 alpha is required for solid tumor formation and embryonic vascularization.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61221

positive regulation of erythrocyte differentiation

1 reference

9 May 2019

Hypoxia-inducible factor-1 deficiency results in dysregulated erythropoiesis signaling and iron homeostasis in mouse development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61221

regulation of thymocyte apoptotic process

1 reference

9 May 2019

Vhlh gene deletion induces Hif-1-mediated cell death in thymocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61221

positive regulation of epithelial cell migration

1 reference

9 May 2019

Hypoxia promotes fibrogenesis in vivo via HIF-1 stimulation of epithelial-to-mesenchymal transition

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61221

negative regulation of thymocyte apoptotic process

1 reference

9 May 2019

Vhlh gene deletion induces Hif-1-mediated cell death in thymocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61221

transcription, DNA-templated

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61221&geneProductId=UniProtKB:Q61221

1 reference

16 July 2018

positive regulation of transcription, DNA-templated

axonal transport of mitochondrion

positive regulation of macroautophagy

1 reference

9 May 2019

Hypoxia-induced autophagy is mediated through hypoxia-inducible factor induction of BNIP3 and BNIP3L via their BH3 domains

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61221

cartilage development

1 reference

9 May 2019

Hypoxia in cartilage: HIF-1alpha is essential for chondrocyte growth arrest and survival

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61221

lactation

1 reference

9 May 2019

HIF1alpha is a critical regulator of secretory differentiation and activation, but not vascular expansion, in the mouse mammary gland

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61221

digestive tract morphogenesis

1 reference

9 May 2019

Loss of hepatocyte-nuclear-factor-1alpha impacts on adult mouse intestinal epithelial cell growth and cell lineages differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61221

neural fold elevation formation

1 reference

9 May 2019

Defective vascularization of HIF-1alpha-null embryos is not associated with VEGF deficiency but with mesenchymal cell death

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61221

positive regulation of autophagy

1 reference

9 May 2019

Mitochondrial autophagy is an HIF-1-dependent adaptive metabolic response to hypoxia

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61221

retina vasculature development in camera-type eye

1 reference

9 May 2019

HIF1A is essential for the development of the intermediate plexus of the retinal vasculature

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61221

collagen metabolic process

1 reference

9 May 2019

Hypoxia promotes fibrogenesis in vivo via HIF-1 stimulation of epithelial-to-mesenchymal transition

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61221

regulation of glycolytic process

1 reference

9 May 2019

The transcription factor HIF-1alpha plays a critical role in the growth factor-dependent regulation of both aerobic and anaerobic glycolysis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61221

cellular response to interleukin-1

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61221

epithelial to mesenchymal transition

1 reference

9 May 2019

Hypoxia promotes fibrogenesis in vivo via HIF-1 stimulation of epithelial-to-mesenchymal transition

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61221

cerebral cortex development

1 reference

9 May 2019

Defective brain development in mice lacking the Hif-1alpha gene in neural cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61221

regulation of gene expression

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61221

9 May 2019

Mitochondrial autophagy is an HIF-1-dependent adaptive metabolic response to hypoxia

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61221

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61221

intestinal epithelial cell maturation

1 reference

9 May 2019

Loss of hepatocyte-nuclear-factor-1alpha impacts on adult mouse intestinal epithelial cell growth and cell lineages differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61221

regulation of catalytic activity

1 reference

9 May 2019

Loss of skeletal muscle HIF-1alpha results in altered exercise endurance

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61221

positive regulation of autophagy of mitochondrion

1 reference

9 May 2019

Mitochondrial autophagy is an HIF-1-dependent adaptive metabolic response to hypoxia

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61221

cardiac ventricle morphogenesis

1 reference

9 May 2019

Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1 alpha

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61221

response to muscle activity

1 reference

9 May 2019

Loss of skeletal muscle HIF-1alpha results in altered exercise endurance

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61221

epithelial cell differentiation involved in mammary gland alveolus development

1 reference

9 May 2019

HIF1alpha is a critical regulator of secretory differentiation and activation, but not vascular expansion, in the mouse mammary gland

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61221

visual learning

1 reference

9 May 2019

Defective brain development in mice lacking the Hif-1alpha gene in neural cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61221

positive regulation of vascular endothelial growth factor receptor signaling pathway

1 reference

9 May 2019

Hypoxia in cartilage: HIF-1alpha is essential for chondrocyte growth arrest and survival

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61221

negative regulation of bone mineralization

1 reference

9 May 2019

Enhanced bone regeneration associated with decreased apoptosis in mice with partial HIF-1alpha deficiency

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61221

negative regulation of growth

1 reference

9 May 2019

Hypoxia in cartilage: HIF-1alpha is essential for chondrocyte growth arrest and survival

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61221

response to hypoxia

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61221

10 references

9 May 2019

9 May 2019

Differential activities of murine single minded 1 (SIM1) and SIM2 on a hypoxic response element. Cross-talk between basic helix-loop-helix/per-Arnt-Sim homology transcription factors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61221

9 May 2019

Hypoxia-induced autophagy is mediated through hypoxia-inducible factor induction of BNIP3 and BNIP3L via their BH3 domains

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61221

9 May 2019

Defective carotid body function and impaired ventilatory responses to chronic hypoxia in mice partially deficient for hypoxia-inducible factor 1 alpha

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61221

9 May 2019

Impaired physiological responses to chronic hypoxia in mice partially deficient for hypoxia-inducible factor 1alpha

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61221

9 May 2019

HIF-1 alpha is required for solid tumor formation and embryonic vascularization.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61221

9 May 2019

The transcription factor HIF-1alpha plays a critical role in the growth factor-dependent regulation of both aerobic and anaerobic glycolysis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61221

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61221

9 May 2019

Angiopoietin 2 stimulates migration and tube-like structure formation of murine brain capillary endothelial cells through c-Fes and c-Fyn

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61221

9 May 2019

Induction of phosphoglycerate kinase 1 gene expression by hypoxia. Roles of Arnt and HIF1alpha

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61221

regulation of transcription from RNA polymerase II promoter in response to oxidative stress

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61221

9 May 2019

Hypoxia-induced gene expression occurs solely through the action of hypoxia-inducible factor 1alpha (HIF-1alpha): role of cytoplasmic trapping of HIF-2alpha

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61221

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61221

iris morphogenesis

1 reference

9 May 2019

Von Hippel-Lindau protein in the RPE is essential for normal ocular growth and vascular development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61221

hypoxia-inducible factor-1alpha signaling pathway

1 reference

9 May 2019

Expression of neural cell adhesion molecule (NCAM) during the first molar development in the mouse

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61221

vasculature development

1 reference

9 May 2019

Cited2 is required for the proper formation of the hyaloid vasculature and for lens morphogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61221

regulation of cell population proliferation

1 reference

9 May 2019

The transcription factor HIF-1alpha plays a critical role in the growth factor-dependent regulation of both aerobic and anaerobic glycolysis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61221

neural crest cell migration

1 reference

9 May 2019

Cardia bifida, defective heart development and abnormal neural crest migration in embryos lacking hypoxia-inducible factor-1alpha

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61221

connective tissue replacement involved in inflammatory response wound healing

1 reference

9 May 2019

Hypoxia promotes fibrogenesis in vivo via HIF-1 stimulation of epithelial-to-mesenchymal transition

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61221

embryonic hemopoiesis

1 reference

9 May 2019

Hypoxia-inducible factor-1 deficiency results in dysregulated erythropoiesis signaling and iron homeostasis in mouse development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61221

positive regulation of transcription from RNA polymerase II promoter in response to hypoxia

negative regulation of reactive oxygen species metabolic process

1 reference

9 May 2019

Mitochondrial autophagy is an HIF-1-dependent adaptive metabolic response to hypoxia

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61221

positive regulation of vascular endothelial growth factor production

elastin metabolic process

1 reference

9 May 2019

Hypoxia promotes fibrogenesis in vivo via HIF-1 stimulation of epithelial-to-mesenchymal transition

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61221

oxygen homeostasis

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61221

9 May 2019

Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1 alpha

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61221

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61221

camera-type eye morphogenesis

1 reference

9 May 2019

Von Hippel-Lindau protein in the RPE is essential for normal ocular growth and vascular development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61221

positive regulation of transcription by RNA polymerase II

9 references

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61221&geneProductId=UniProtKB:Q61221

16 July 2018

The survival effect of mitochondrial Higd-1a is associated with suppression of cytochrome C release and prevention of caspase activation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61221&geneProductId=UniProtKB:Q61221

16 July 2018

Acute postnatal ablation of Hif-2alpha results in anemia

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61221&geneProductId=UniProtKB:Q61221

16 July 2018

A novel bHLH-PAS factor with close sequence similarity to hypoxia-inducible factor 1alpha regulates the VEGF expression and is potentially involved in lung and vascular development

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61221&geneProductId=UniProtKB:Q61221

16 July 2018

Retinoic acid, hypoxia, and GATA factors cooperatively control the onset of fetal liver erythropoietin expression and erythropoietic differentiation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61221&geneProductId=UniProtKB:Q61221

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61221&geneProductId=UniProtKB:Q61221

16 July 2018

Induction of phosphoglycerate kinase 1 gene expression by hypoxia. Roles of Arnt and HIF1alpha

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61221&geneProductId=UniProtKB:Q61221

16 July 2018

Advanced glycated end-products affect HIF-transcriptional activity in renal cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61221&geneProductId=UniProtKB:Q61221

16 July 2018

The hypoxia-inducible microRNA cluster miR-199a∼214 targets myocardial PPARδ and impairs mitochondrial fatty acid oxidation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61221&geneProductId=UniProtKB:Q61221

cellular iron ion homeostasis

1 reference

9 May 2019

Hypoxia-inducible factor-1 deficiency results in dysregulated erythropoiesis signaling and iron homeostasis in mouse development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61221

response to iron ion

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61221

negative regulation of transcription by RNA polymerase II

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61221

positive regulation of cell population proliferation

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61221

positive regulation of apoptotic process

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61221

negative regulation of apoptotic process

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61221

9 May 2019

Mitochondrial autophagy is an HIF-1-dependent adaptive metabolic response to hypoxia

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61221

9 May 2019

Enhanced bone regeneration associated with decreased apoptosis in mice with partial HIF-1alpha deficiency

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61221

positive regulation of gluconeogenesis

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61221

negative regulation of vasoconstriction

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61221

positive regulation of smooth muscle cell proliferation

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61221

response to fungicide

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61221

regulation of transcription by RNA polymerase II

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61221

positive regulation of transcription by RNA polymerase II

10 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61221

9 May 2019

The survival effect of mitochondrial Higd-1a is associated with suppression of cytochrome C release and prevention of caspase activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61221

9 May 2019

Acute postnatal ablation of Hif-2alpha results in anemia

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61221

9 May 2019

A novel bHLH-PAS factor with close sequence similarity to hypoxia-inducible factor 1alpha regulates the VEGF expression and is potentially involved in lung and vascular development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61221

9 May 2019

Retinoic acid, hypoxia, and GATA factors cooperatively control the onset of fetal liver erythropoietin expression and erythropoietic differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61221

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61221

9 May 2019

Induction of phosphoglycerate kinase 1 gene expression by hypoxia. Roles of Arnt and HIF1alpha

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61221

9 May 2019

Advanced glycated end-products affect HIF-transcriptional activity in renal cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61221

9 May 2019

The hypoxia-inducible microRNA cluster miR-199a∼214 targets myocardial PPARδ and impairs mitochondrial fatty acid oxidation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61221

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61221

Myc-type, basic helix-loop-helix (bHLH) domain

has part(s)

1 reference

PAS fold-3

1 reference

HIF-1 alpha, transactivation domain, C-terminal

1 reference

PAC motif

1 reference

PAS fold

1 reference

PAS domain

1 reference