Neutrophil cytosolic factor 1 (Q21988713)

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mammalian protein found in Mus musculus

Ncf1
47 kDa neutrophil oxidase factor
neutrophil NADPH oxidase factor 1
NCF-47K
NADPH oxidase subunit (47kDa)
neutrophil cytosol factor 1
p47-phox
NADPH oxidase subunit (47 kD)

Language	Label	Description	Also known as
English	Neutrophil cytosolic factor 1	mammalian protein found in Mus musculus	Ncf1 47 kDa neutrophil oxidase factor neutrophil NADPH oxidase factor 1 NCF-47K NADPH oxidase subunit (47kDa) neutrophil cytosol factor 1 p47-phox NADPH oxidase subunit (47 kD)

Statements

1 reference

25 May 2022

UniProt protein ID

SH3-like domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q09014

PX domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q09014

Neutrophil cytosol factor 1

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q09014

membrane protein

1 reference

based on heuristic

inferred from GOA cell component → membrane

Phox homologous domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Neutrophil cytosol factor 1, C-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Neutrophil cytosol factor 1, second SH3 domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

NADPH oxidase subunit p47Phox, C-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Neutrophil cytosol factor 1, PX domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Neutrophil cytosol factor 1, first SH3 domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

SH3 domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

molecular function

SH3 domain binding

determination method or standard

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q09014

determination method or standard

protein binding

determination method or standard

determination method or standard

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q09014

determination method or standard

superoxide-generating NADPH oxidase activator activity

determination method or standard

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q09014

determination method or standard

phosphatidylinositol binding

determination method or standard

4 references

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q09014

determination method or standard

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q09014

determination method or standard

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q09014

determination method or standard

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q09014

determination method or standard

superoxide-generating NAD(P)H oxidase activity

determination method or standard

4 references

14 February 2019

Cloning and expression of bovine p47-phox and p67-phox: comparison with the human and murine homologs

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q09014

determination method or standard

14 February 2019

Oxidants from nicotinamide adenine dinucleotide phosphate oxidase are involved in triggering cell proliferation in the liver due to peroxisome proliferators

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q09014

determination method or standard

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q09014

determination method or standard

14 February 2019

Cloning and functional expression of the mouse homologue of p47phox

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q09014

determination method or standard

phosphatidylinositol-3,4-bisphosphate binding

determination method or standard

3 references

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q09014

determination method or standard

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q09014

determination method or standard

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q09014

determination method or standard

determination method or standard

5 references

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q09014

determination method or standard

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q09014

determination method or standard

14 February 2019

Park7 interacts with p47(phox) to direct NADPH oxidase-dependent ROS production and protect against sepsis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q09014

determination method or standard

14 February 2019

Identification of non-mitochondrial NADPH oxidase and the spatio-temporal organization of its components in mouse spermatozoa

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q09014

determination method or standard

14 February 2019

Genetic requirement of p47phox for superoxide production by murine microglia

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q09014

determination method or standard

determination method or standard

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q09014&geneProductId=UniProtKB:Q09014

determination method or standard

plasma membrane

determination method or standard

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q09014

determination method or standard

determination method or standard

3 references

24 April 2018

Molecular characterization of the mouse p47-phox (Ncf1) gene and comparative analysis of the mouse p47-phox (Ncf1) gene to the human NCF1 gene

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q09014&geneProductId=UniProtKB:Q09014

determination method or standard

24 April 2018

Cloning and expression of bovine p47-phox and p67-phox: comparison with the human and murine homologs

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q09014&geneProductId=UniProtKB:Q09014

determination method or standard

24 April 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q09014&geneProductId=UniProtKB:Q09014

determination method or standard

rough endoplasmic reticulum

determination method or standard

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q09014

determination method or standard

Golgi apparatus

determination method or standard

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q09014

determination method or standard

determination method or standard

3 references

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q09014

determination method or standard

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q09014

determination method or standard

14 February 2019

Park7 interacts with p47(phox) to direct NADPH oxidase-dependent ROS production and protect against sepsis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q09014

determination method or standard

determination method or standard

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q09014

determination method or standard

determination method or standard

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q09014

determination method or standard

determination method or standard

4 references

14 February 2019

Molecular characterization of the mouse p47-phox (Ncf1) gene and comparative analysis of the mouse p47-phox (Ncf1) gene to the human NCF1 gene

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q09014

determination method or standard

14 February 2019

Cloning and expression of bovine p47-phox and p67-phox: comparison with the human and murine homologs

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q09014

determination method or standard

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q09014

determination method or standard

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q09014

determination method or standard

NADPH oxidase complex

determination method or standard

3 references

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q09014

determination method or standard

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q09014

determination method or standard

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q09014

determination method or standard

biological process

defense response to Gram-positive bacterium

determination method or standard

1 reference

14 February 2019

Killing activity of neutrophils is mediated through activation of proteases by K+ flux

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q09014

determination method or standard

leukotriene metabolic process

determination method or standard

1 reference

14 February 2019

Thioglycollate peritonitis in mice lacking C5, 5-lipoxygenase, or p47(phox): complement, leukotrienes, and reactive oxidants in acute inflammation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q09014

determination method or standard

neutrophil-mediated killing of gram-positive bacterium

determination method or standard

1 reference

14 February 2019

Killing activity of neutrophils is mediated through activation of proteases by K+ flux

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q09014

determination method or standard

respiratory burst involved in defense response

determination method or standard

1 reference

14 February 2019

Impaired immunity and enhanced resistance to endotoxin in the absence of neutrophil elastase and cathepsin G

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q09014

determination method or standard

response to bacterium

determination method or standard

1 reference

14 February 2019

Transient loss of resistance to pulmonary tuberculosis in p47(phox-/-) mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q09014

determination method or standard

defense response to fungus

determination method or standard

superoxide anion generation

determination method or standard

3 references

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q09014

determination method or standard

14 February 2019

Vascular effects following homozygous disruption of p47(phox) : An essential component of NADPH oxidase

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q09014

determination method or standard

14 February 2019

Genetic requirement of p47phox for superoxide production by murine microglia

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q09014

determination method or standard

cellular defense response

determination method or standard

1 reference

14 February 2019

The p47phox mouse knock-out model of chronic granulomatous disease

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q09014

determination method or standard

leukocyte mediated cytotoxicity

determination method or standard

1 reference

14 February 2019

Transcriptome analysis of murine macrophages in response to infection with Streptococcus pyogenes reveals an unusual activation program

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q09014

determination method or standard

defense response to bacterium

determination method or standard

neutrophil-mediated killing of fungus

determination method or standard

1 reference

14 February 2019

Killing activity of neutrophils is mediated through activation of proteases by K+ flux

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q09014

determination method or standard

hydrogen peroxide biosynthetic process

determination method or standard

1 reference

14 February 2019

T cells express a phagocyte-type NADPH oxidase that is activated after T cell receptor stimulation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q09014

determination method or standard

cell population proliferation

determination method or standard

1 reference

14 February 2019

Oxidants from nicotinamide adenine dinucleotide phosphate oxidase are involved in triggering cell proliferation in the liver due to peroxisome proliferators

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q09014

determination method or standard

inflammatory response

determination method or standard

1 reference

14 February 2019

Thioglycollate peritonitis in mice lacking C5, 5-lipoxygenase, or p47(phox): complement, leukotrienes, and reactive oxidants in acute inflammation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q09014

determination method or standard

podosome assembly

determination method or standard

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q09014&geneProductId=UniProtKB:Q09014

determination method or standard

positive regulation of phosphatidylinositol 3-kinase signaling

determination method or standard

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q09014

determination method or standard

cellular response to reactive oxygen species

determination method or standard

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q09014

determination method or standard

positive regulation of epidermal growth factor-activated receptor activity

determination method or standard

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q09014

determination method or standard

positive regulation of transcription, DNA-templated

determination method or standard

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q09014

determination method or standard

positive regulation of JNK cascade

determination method or standard

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q09014

determination method or standard

cellular response to cadmium ion

determination method or standard

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q09014

determination method or standard

positive regulation of p38MAPK cascade

determination method or standard

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q09014

determination method or standard

NADP catabolic process

determination method or standard

1 reference

14 February 2019

Cloning and expression of bovine p47-phox and p67-phox: comparison with the human and murine homologs

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q09014

determination method or standard

apoptotic process

determination method or standard

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q09014

determination method or standard

superoxide metabolic process

determination method or standard

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q09014

determination method or standard

respiratory burst

determination method or standard

3 references

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q09014

determination method or standard

14 February 2019

Conditional haploinsufficiency of NCF1 (encoding p47(phox)), a signaling gene with a heterozygous phenotype potentially subject to natural selection

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q09014

determination method or standard

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q09014

determination method or standard

Phox homologous domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q09014

Neutrophil cytosol factor 1, C-terminal

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q09014

NADPH oxidase subunit p47Phox, C-terminal

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q09014

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q09014

Neutrophil cytosol factor 1, PX domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q09014

Neutrophil cytosol factor 1, first SH3 domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q09014

Neutrophil cytosol factor 1, second SH3 domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q09014

Identifiers

RefSeq protein ID

1 reference

20 March 2022

1 reference

20 March 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

Ensembl protein ID

ENSMUSP00000106906

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000106906

ENSMUSP00000138121

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000138121

ENSMUSP00000016094

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000016094

ENSMUSP00000138547

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000138547

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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