Genetic correlates of longevity and selected age-related phenotypes: a genome-wide association study in the Framingham Study (Q21261434)

17 August 2022

Emelia J Benjamin

Emelia J

Benjamin

1 reference

17 August 2022

Margaret Kelly-Hayes

Margaret

Kelly-Hayes

1 reference

17 August 2022

David Karasik

David

Karasik

1 reference

17 August 2022

Joanne M Murabito

Joanne M

Murabito

1 reference

17 August 2022

Michael J Pencina

Michael J

Pencina

1 reference

17 August 2022

Joseph M Massaro

Joseph M

Massaro

1 reference

17 August 2022

Kathryn L Lunetta

Kathryn L

Lunetta

1 reference

17 August 2022

Douglas P Kiel

Douglas P

Kiel

1 reference

17 August 2022

Ralph B. D'Agostino Sr.

Ralph B

D'Agostino

Ralph B D'Agostino

1 reference

17 August 2022

Chao-Yu Guo

Chao-Yu

Guo

1 reference

17 August 2022

Raju Govindaraju

series ordinal

author given names

Raju

author last names

Govindaraju

1 reference

Creative Commons Attribution 2.0 Generic

17 August 2022

language of work or name

English

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publication date

2007

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published in

BMC Medical Genetics

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volume

8 Suppl 1

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issue

Suppl 1

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page(s)

S13

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start time

1 September 2007

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April 2022 Public Data File from Crossref

copyrighted

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describes a project that uses

genome-wide association study

1 reference

Suppression of aging in mice by the hormone Klotho

inferred from title

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1995604

The human genome browser at UCSC

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1995604

Mutation of the mouse klotho gene leads to a syndrome resembling ageing

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1995604

The genetics of human longevity

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1995604

A comprehensive review of genetic association studies

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1995604

The UCSC Genome Browser Database

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1995604

Heritability of cognitive performance in aging twins. The National Heart, Lung, and Blood Institute Twin Study

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1995604

Disentangling the genetic determinants of human aging: biological age as an alternative to the use of survival measures

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1995604

Genetic contribution to biological aging: the Framingham Study

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1995604

Suppression of ovarian follicle activation in mice by the transcription factor Foxo3a

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1995604

Genome-wide association studies for common diseases and complex traits

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1995604

The Framingham Heart Study 100K SNP genome-wide association study resource: overview of 17 phenotype working group reports

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1995604

FOXO transcription factors: key regulators of cell fate

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1995604

Chromosome 4q25, microsomal transfer protein gene, and human longevity: novel data and a meta-analysis of association studies

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1995604

No association between microsomal triglyceride transfer protein (MTP) haplotype and longevity in humans

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1995604

FoxO proteins in insulin action and metabolism

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1995604

Role of insulin/insulin-like growth factor 1 signaling pathway in longevity.

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1995604

The role of insulin and IGF-1 signaling in longevity

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1995604

A novel VNTR enhancer within the SIRT3 gene, a human homologue of SIR2, is associated with survival at oldest ages.

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1995604

Exceptional survival in human populations: National Institute on Aging perspectives and programs

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1995604

Association analysis between longevity in the Japanese population and polymorphic variants of genes involved in insulin and insulin-like growth factor 1 signaling pathways

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1995604

Drosophila dFOXO controls lifespan and regulates insulin signalling in brain and fat body

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1995604

Haplotype-based identification of a microsomal transfer protein marker associated with the human lifespan

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1995604

FoxO3a eggs on fertility and aging

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1995604

Heritability and validity of healthy physical aging (wellness) in elderly male twins.

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1995604

A genome-wide scan for linkage to human exceptional longevity identifies a locus on chromosome 4.

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1995604

How heritable is individual susceptibility to death? The results of an analysis of survival data on Danish, Swedish and Finnish twins

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1995604

The heritability of human longevity: a population-based study of 2872 Danish twin pairs born 1870-1900.

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1995604

The contribution of genetic influences to measures of lower-extremity function in older male twins

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1995604

Longevity is moderately heritable in a sample of Danish twins born 1870-1880.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1995604

Haplotypes in the human Foxo1a and Foxo3a genes; impact on disease and mortality at old age

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1995604

Genetic influence on human lifespan and longevity.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1995604

Genome-wide linkage analysis to age at natural menopause in a community-based sample: the Framingham Heart Study

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1995604

Regulation of multiple ageing-like phenotypes by inducible klotho gene expression in klotho mutant mice

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1995604

Reduced insulin/IGF-1 signalling and human longevity.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1995604

Heritability of Age at Natural Menopause in the Framingham Heart Study

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1995604

Association between a functional variant of the KLOTHO gene and high-density lipoprotein cholesterol, blood pressure, stroke, and longevity

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1995604

Variability of the SIRT3 gene, human silent information regulator Sir2 homologue, and survivorship in the elderly

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1995604

Polymorphic variants of insulin-like growth factor I (IGF-I) receptor and phosphoinositide 3-kinase genes affect IGF-I plasma levels and human longevity: cues for an evolutionarily conserved mechanism of life span control

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1995604

No evidence for an association between extreme longevity and microsomal transfer protein polymorphisms in a longitudinal study of 1651 nonagenarians

29 November 2018

1 reference

12 December 2020

Possible associations between successful aging and polymorphic markers in the Werner gene region

1 reference

12 December 2020

Genome-wide scan for a healthy aging phenotype provides support for a locus near D4S1564 promoting healthy aging

1 reference

12 December 2020

Genetic influences and grip strength norms in the NHLBI twin study males aged 59–69

1 reference

12 December 2020

The effect of genetic factors for longevity: a comparison of identical and fraternal twins in the Swedish Twin Registry

1 reference

12 December 2020

10.1186/1471-2350-8-S1-S13

Identifiers

DOI

1 reference

0 references

1 reference

1 reference

PubMed publication ID

17903295

1 reference