The genetics of human longevity (Q21710733)

7 February 2023

Arnold J. Kahn

Arnold J

Kahn

1 reference

7 February 2023

Elad Ziv

Elad

Ziv

1 reference

7 February 2023

Alexander P. Reiner

Alexander P

Reiner

1 reference

7 February 2023

Junko Oshima

Junko

Oshima

1 reference

7 February 2023

Richard M. Cawthon

Richard M

Cawthon

1 reference

7 February 2023

Wen-Chi Hsueh

Wen-Chi

Hsueh

1 reference

7 February 2023

Steven R. Cummings

Steven R

Cummings

1 reference

American Journal of Medicine

7 February 2023

language of work or name

English

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publication date

December 2004

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published in

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volume

117

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issue

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page(s)

851-860

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cites work

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Grandmothers and the evolution of human longevity

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Heritability of life span in the Old Order Amish.

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Mutation screening of the macrophage migration inhibitory factor gene: positive association of a functional polymorphism of macrophage migration inhibitory factor with juvenile idiopathic arthritis

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Functional and prognostic relevance of the -173 polymorphism of the macrophage migration inhibitory factor gene in systemic-onset juvenile idiopathic arthritis

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Unbiased methods for population-based association studies

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Regulation of c-fos expression in senescing Werner syndrome fibroblasts differs from that observed in senescing fibroblasts from normal donors

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Caloric restriction and aging in primates: Relevance to humans and possible CR mimetics

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Differential occurrence of mutations in mitochondrial DNA of human skeletal muscle during aging

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Caloric Restriction Attenuates Dityrosine Cross-Linking of Cardiac and Skeletal Muscle Proteins in Aging Mice

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Nutrition, oxidative damage, telomere shortening, and cellular senescence: individual or connected agents of aging?

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The structure of human mitochondrial DNA variation.

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The heritability of human longevity: A population-based study of 2872 Danish twin pairs born 1870–1900

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Accelerated loss of telomeric repeats may not explain accelerated replicative decline of Werner syndrome cells

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Regulation of longevity and stress resistance: a molecular strategy conserved from yeast to humans?

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Mitochondrial DNA polymorphisms associated with longevity in a Finnish population

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Mitochondrial DNA mutations in human degenerative diseases and aging

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Variation in the SHC1 gene and longevity in humans

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Elevated levels of tumor necrosis factor alpha and mortality in centenarians

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Associations of elevated interleukin-6 and C-reactive protein levels with mortality in the elderly

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Mitochondria, aging and longevity--a new perspective.

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Biological effects of resveratrol

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Mitochondrial genotype associated with longevity and its inhibitory effect on mutagenesis

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Stress resistance as a determinate of C. elegans lifespan

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Implications for the insulin signaling pathway in Snell dwarf mouse longevity: a similarity with the C. elegans longevity paradigm

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7 January 2021

Hierarchical deterioration of body systems in Werner's syndrome: Implications for normal ageing

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7 January 2021

Telomere shortening in atherosclerosis

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7 January 2021

Association between telomere length in blood and mortality in people aged 60 years or older

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7 January 2021

Population stratification and spurious allelic association

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7 January 2021

LMNA mutations in atypical Werner's syndrome

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7 January 2021

Mitochondrial DNA mutations as an important contributor to ageing and degenerative diseases

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7 January 2021

Telomere shortening in T cells correlates with Alzheimer's disease status.

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7 January 2021

Epigenetics: interaction of DNA methylation and chromatin

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7 January 2021

Quantification of human mitochondrial DNA in a real time PCR

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7 January 2021

Caloric restriction and aging: an update

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7 January 2021

Oxidative damage to mitochondria and aging

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7 January 2021

Mitochondrial DNA polymorphism: its role in longevity of the Irish population

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7 January 2021

An in vitro model of caloric restriction

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7 January 2021

Positive correlation between mammalian life span and cellular resistance to stress.

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7 January 2021

Telomere shortening and cell fates in mouse models of neoplasia

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7 January 2021

Growth hormone insensitivity (Laron syndrome).

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7 January 2021

Insulin-like growth factor 1 (IGF-1) and aging: controversies and new insights

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Population stratification in the candidate gene study: fatal threat or red herring?

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The premature ageing syndrome protein, WRN, is a 3'-->5' exonuclease

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7 January 2021

Genetic pathways that regulate ageing in model organisms

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7 January 2021

Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans

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7 January 2021

The RNA component of telomerase is mutated in autosomal dominant dyskeratosis congenita

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7 January 2021

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A C. elegans mutant that lives twice as long as wild type

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7 January 2021

Lifespan: catch-up growth and obesity in male mice

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7 January 2021

The p66shc adaptor protein controls oxidative stress response and life span in mammals

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7 January 2021

Short telomeres in patients with vascular dementia: an indicator of low antioxidative capacity and a possible risk factor?

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7 January 2021

IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice

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7 January 2021

Recurrent de novo point mutations in lamin A cause Hutchinson–Gilford progeria syndrome

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7 January 2021

A progeroid syndrome in mice is caused by defects in A-type lamins

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7 January 2021

Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan

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7 January 2021

The International HapMap Project

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7 January 2021

Fitness benefits of prolonged post-reproductive lifespan in women

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7 January 2021

X-linked dyskeratosis congenita is caused by mutations in a highly conserved gene with putative nucleolar functions

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7 January 2021

The Werner syndrome protein is a DNA helicase

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7 January 2021

Discovering genotypes underlying human phenotypes: past successes for mendelian disease, future approaches for complex disease

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7 January 2021

Metabolic integration during the evolutionary origin of mitochondria

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7 January 2021

A functional promoter polymorphism in the macrophage migration inhibitory factor (MIF) gene associated with disease severity in rheumatoid arthritis

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7 January 2021

Macrophage migration inhibitory factor (MIF) gene polymorphism is associated with susceptibility to but not severity of inflammatory polyarthritis

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7 January 2021

Lifespan extension in C. elegans by a molecular chaperone dependent upon insulin-like signals

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7 January 2021

Toll-like Receptor 4 Polymorphisms and Atherogenesis

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7 January 2021

Life-long sustained mortality advantage of siblings of centenarians

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7 January 2021

Haplotype-based identification of a microsomal transfer protein marker associated with the human lifespan

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7 January 2021

Strikingly higher frequency in centenarians and twins of mtDNA mutation causing remodeling of replication origin in leukocytes

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7 January 2021

Thermotolerance and extended life-span conferred by single-gene mutations and induced by thermal stress

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7 January 2021

The PTEN tumor suppressor homolog in Caenorhabditis elegans regulates longevity and dauer formation in an insulin receptor-like signaling pathway

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7 January 2021

A model for antagonistic pleiotropic gene action for mortality and advanced age

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7 January 2021

Use of unlinked genetic markers to detect population stratification in association studies.

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7 January 2021

Sample Size Needed to Detect Gene-Gene Interactions using Association Designs

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7 January 2021

Hypothesis: Interventions That Increase the Response to Stress Offer the Potential for Effective Life Prolongation and Increased Health

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7 January 2021

Cellular proliferative capacity and life span in small and large dogs

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7 January 2021

Kleemeier award lecture: are there genes for aging?

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7 January 2021

Why do life spans differ? Partitioning mean longevity differences in terms of age-specific mortality parameters.

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7 January 2021

Searching for human longevity genes: the future history of gerontology in the post-genomic era.

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7 January 2021

Models of growth hormone and IGF-1 deficiency: applications to studies of aging processes and life-span determination

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7 January 2021

Morbidity profiles of centenarians: survivors, delayers, and escapers

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7 January 2021

Cardiovascular Advantages Among the Offspring of Centenarians

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7 January 2021

The effect of caloric restriction on glycation and glycoxidation in skin collagen of nonhuman primates

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7 January 2021

Dietary restriction, tumors, and aging in rodents

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7 January 2021

Detecting population stratification using a panel of single nucleotide polymorphisms

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7 January 2021

Role of the heat shock response and molecular chaperones in oncogenesis and cell death

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7 January 2021

Telomere dysfunction: a potential cancer predisposition factor.

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7 January 2021

Mitochondrial DNA inherited variants are associated with successful aging and longevity in humans

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7 January 2021

Multiplex stress resistance in cells from long-lived dwarf mice.

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7 January 2021

Heat shock of Drosophila melanogaster induces the synthesis of new messenger RNAs and proteins

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7 January 2021

Extending life: scientific prospects and political obstacles

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7 January 2021

What geriatricians should know about the Werner syndrome

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7 January 2021

Mechanisms of caloric restriction affecting aging and disease

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7 January 2021

A mutant Drosophila insulin receptor homolog that extends life-span and impairs neuroendocrine function

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7 January 2021

Extension of life-span by loss of CHICO, a Drosophila insulin receptor substrate protein

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7 January 2021

Regulation of longevity and stress resistance by Sch9 in yeast

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7 January 2021

DNA repair pathway stimulated by the forkhead transcription factor FOXO3a through the Gadd45 protein

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7 January 2021

Redox regulation of forkhead proteins through a p66shc-dependent signaling pathway

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7 January 2021

Evolutionary medicine: from dwarf model systems to healthy centenarians?

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7 January 2021

Extended longevity in mice lacking the insulin receptor in adipose tissue

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7 January 2021

Dyskeratosis congenita and cancer in mice deficient in ribosomal RNA modification

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7 January 2021

The endocrine regulation of aging by insulin-like signals

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7 January 2021

Genetics and the specificity of the aging process

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7 January 2021

Regulation of Aging and Age-Related Disease by DAF-16 and Heat-Shock Factor

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7 January 2021

Demography of dietary restriction and death in Drosophila

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7 January 2021

Effects of purifying and adaptive selection on regional variation in human mtDNA.

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7 January 2021

Yeast life-span extension by calorie restriction is independent of NAD fluctuation

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7 January 2021

Breast and ovarian cancer risks due to inherited mutations in BRCA1 and BRCA2

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7 January 2021

Healthy Animals with Extreme Longevity

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7 January 2021

Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase

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7 January 2021

Positional cloning of the Werner's syndrome gene

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7 January 2021

Determination of life-span in Caenorhabditis elegans by four clock genes

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7 January 2021

Oxidative stress, caloric restriction, and aging

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https://api.crossref.org/works/10.1016%2FJ.AMJMED.2004.06.033

7 January 2021

Cancer chemopreventive activity of resveratrol, a natural product derived from grapes

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https://api.crossref.org/works/10.1016%2FJ.AMJMED.2004.06.033

7 January 2021

daf-2 , an Insulin Receptor-Like Gene That Regulates Longevity and Diapause in Caenorhabditis elegans

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7 January 2021

daf-16: An HNF-3/forkhead family member that can function to double the life-span of Caenorhabditis elegans

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7 January 2021

Extended life-span and stress resistance in the Drosophila mutant methuselah

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7 January 2021

Gene expression profile of aging and its retardation by caloric restriction

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7 January 2021

Toxicity of ALS-linked SOD1 mutants

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7 January 2021

Mutations in the WRN gene in mice accelerate mortality in a p53-null background

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7 January 2021

Telomeres and their control

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7 January 2021

Age-associated increased interleukin-6 gene expression, late-life diseases, and frailty

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7 January 2021

Mitochondrial genotype associated with French Caucasian centenarians

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7 January 2021

Olive oil and red wine antioxidant polyphenols inhibit endothelial activation: antiatherogenic properties of Mediterranean diet phytochemicals

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7 January 2021

Variants of toll-like receptor 4 modify the efficacy of statin therapy and the risk of cardiovascular events

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7 January 2021

Cardiovascular disease, interleukin-6, and risk of mortality in older women: the women's health and aging study

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7 January 2021

How we detect microbes and respond to them: the Toll-like receptors and their transducers

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7 January 2021

Deletion, but not antagonism, of the mouse growth hormone receptor results in severely decreased body weights, insulin, and insulin-like growth factor I levels and increased life span

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7 January 2021

Polymorphic variants of insulin-like growth factor I (IGF-I) receptor and phosphoinositide 3-kinase genes affect IGF-I plasma levels and human longevity: cues for an evolutionarily conserved mechanism of life span control

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7 January 2021

Gene expression patterns in calorically restricted mice: partial overlap with long-lived mutant mice.

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7 January 2021

Finding genes influencing susceptibility to complex diseases in the post-genome era.

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7 January 2021

The effect of caloric restriction on the aortic tissue of aging rats.

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7 January 2021

Heat shock proteins as cellular lifeguards

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7 January 2021

10.1016/J.AMJMED.2004.06.033

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