Alcohol dehydrogenase 4 (class II), pi polypeptide (Q21157766)

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mammalian protein found in Homo sapiens

all-trans-retinol dehydrogenase [NAD(+)] ADH4
alcohol dehydrogenase 4
alcohol dehydrogenase class II pi chain
epididymis secretory protein Li 4
ADH4
aldehyde reductase

Language	Label	Description	Also known as
English	Alcohol dehydrogenase 4 (class II), pi polypeptide	mammalian protein found in Homo sapiens	all-trans-retinol dehydrogenase [NAD(+)] ADH4 alcohol dehydrogenase 4 alcohol dehydrogenase class II pi chain epididymis secretory protein Li 4 ADH4 aldehyde reductase

Statements

1 reference

13 November 2019

UniProt protein ID

1 reference

1 December 2016

UniProt protein ID

NAD(P)-binding domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P08319

Alcohol dehydrogenase family, zinc-type, class-II subfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P08319

GroES-like superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P08319

Polyketide synthase, enoylreductase domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Alcohol dehydrogenase, C-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Alcohol dehydrogenase, N-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Alcohol dehydrogenase, zinc-type, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

benzaldehyde dehydrogenase [NAD(P)+] activity

determination method or standard

1 reference

8 April 2019

Human class II (pi) alcohol dehydrogenase has a redox-specific function in norepinephrine metabolism

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08319

determination method or standard

all-trans retinal binding

determination method or standard

1 reference

8 April 2019

Kinetics of human alcohol dehydrogenase with ring-oxidized retinoids: effect of Tween 80

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08319

determination method or standard

alditol:NADP+ 1-oxidoreductase activity

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08319

determination method or standard

determination method or standard

1 reference

8 April 2019

Molecular docking studies on interaction of diverse retinol structures with human alcohol dehydrogenases predict a broad role in retinoid ligand synthesis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08319

determination method or standard

metal ion binding

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08319

determination method or standard

oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

determination method or standard

1 reference

8 April 2019

Human class II (pi) alcohol dehydrogenase has a redox-specific function in norepinephrine metabolism

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08319

determination method or standard

retinol binding

determination method or standard

1 reference

8 April 2019

Molecular docking studies on interaction of diverse retinol structures with human alcohol dehydrogenases predict a broad role in retinoid ligand synthesis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08319

determination method or standard

alcohol dehydrogenase (NAD+) activity

determination method or standard

4 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08319

determination method or standard

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08319

determination method or standard

8 April 2019

Comparative functional analysis of human medium-chain dehydrogenases, short-chain dehydrogenases/reductases and aldo-keto reductases with retinoids

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08319

determination method or standard

8 April 2019

Human class II (pi) alcohol dehydrogenase has a redox-specific function in norepinephrine metabolism

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08319

determination method or standard

alcohol dehydrogenase activity, zinc-dependent

determination method or standard

4 references

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08319&geneProductId=UniProtKB:P08319

determination method or standard

5 June 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08319&geneProductId=UniProtKB:P08319

determination method or standard

5 June 2018

Molecular docking studies on interaction of diverse retinol structures with human alcohol dehydrogenases predict a broad role in retinoid ligand synthesis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08319&geneProductId=UniProtKB:P08319

determination method or standard

5 June 2018

Human liver alcohol dehydrogenase: purification, composition, and catalytic features

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08319&geneProductId=UniProtKB:P08319

determination method or standard

NAD-retinol dehydrogenase activity

determination method or standard

3 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08319&geneProductId=UniProtKB:P08319

determination method or standard

1 January 2018

Kinetics of human alcohol dehydrogenase with ring-oxidized retinoids: effect of Tween 80

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08319&geneProductId=UniProtKB:P08319

determination method or standard

1 January 2018

Comparative functional analysis of human medium-chain dehydrogenases, short-chain dehydrogenases/reductases and aldo-keto reductases with retinoids

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08319&geneProductId=UniProtKB:P08319

determination method or standard

ethanol binding

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08319

determination method or standard

alcohol dehydrogenase activity, zinc-dependent

determination method or standard

5 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08319&geneProductId=UniProtKB:P08319

determination method or standard

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08319&geneProductId=UniProtKB:P08319

determination method or standard

1 January 2018

Molecular docking studies on interaction of diverse retinol structures with human alcohol dehydrogenases predict a broad role in retinoid ligand synthesis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08319&geneProductId=UniProtKB:P08319

determination method or standard

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08319&geneProductId=UniProtKB:P08319

determination method or standard

1 January 2018

Human liver alcohol dehydrogenase: purification, composition, and catalytic features

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08319&geneProductId=UniProtKB:P08319

determination method or standard

zinc ion binding

determination method or standard

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08319

determination method or standard

8 April 2019

Molecular docking studies on interaction of diverse retinol structures with human alcohol dehydrogenases predict a broad role in retinoid ligand synthesis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08319

determination method or standard

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08319

determination method or standard

S-(hydroxymethyl)glutathione dehydrogenase activity

determination method or standard

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08319

determination method or standard

alcohol dehydrogenase activity, zinc-dependent

determination method or standard

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08319

determination method or standard

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08319

determination method or standard

8 April 2019

Molecular docking studies on interaction of diverse retinol structures with human alcohol dehydrogenases predict a broad role in retinoid ligand synthesis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08319

determination method or standard

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08319

determination method or standard

NAD-retinol dehydrogenase activity

determination method or standard

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08319

determination method or standard

determination method or standard

1 reference

8 April 2019

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08319

determination method or standard

determination method or standard

biological process

retinol metabolic process

determination method or standard

1 reference

8 April 2019

Comparative functional analysis of human medium-chain dehydrogenases, short-chain dehydrogenases/reductases and aldo-keto reductases with retinoids

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08319

determination method or standard

retinoid metabolic process

determination method or standard

1 reference

8 April 2019

Kinetics of human alcohol dehydrogenase with ring-oxidized retinoids: effect of Tween 80

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08319

determination method or standard

ethanol metabolic process

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08319

determination method or standard

alcohol metabolic process

determination method or standard

1 reference

8 April 2019

Human class II (pi) alcohol dehydrogenase has a redox-specific function in norepinephrine metabolism

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08319

determination method or standard

ethanol oxidation

determination method or standard

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08319

determination method or standard

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08319

determination method or standard

8 April 2019

Comparative functional analysis of human medium-chain dehydrogenases, short-chain dehydrogenases/reductases and aldo-keto reductases with retinoids

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08319

determination method or standard

formaldehyde catabolic process

determination method or standard

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08319

determination method or standard

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000265512

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000265512

ENSP00000424630

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000424630

ENSP00000425416

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000425416

ENSP00000423571

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000423571

ENSP00000424583

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000424583

ENSP00000426667

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000426667

ENSP00000427261

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000427261

ENSP00000427525

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000427525

ENSP00000486450

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000486450

PDB structure ID

1 reference

UniProt protein ID

9 August 2016

language of work or name

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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