Synuclein alpha interacting protein (Q21127234)

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mammalian protein found in Homo sapiens

• SNCAIP
• Alpha-synuclein-interacting protein
• synphilin-1

edit

Language	Label	Description	Also known as
English	Synuclein alpha interacting protein	mammalian protein found in Homo sapiens	SNCAIP Alpha-synuclein-interacting protein synphilin-1

Statements

instance of

protein

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

Q9Y6H5

subclass of

protein

1 reference

stated in

UniProt

retrieved

1 December 2016

UniProt protein ID

Q9Y6H5

found in taxon

Homo sapiens

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

Q9Y6H5

encoded by

SNCAIP

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

Q9Y6H5

molecular function

protein binding

determination method or standard

IPI

6 references

retrieved

8 April 2019

stated in

Parkin ubiquitinates the alpha-synuclein-interacting protein, synphilin-1: implications for Lewy-body formation in Parkinson disease

GOA

curator

UniProt

UniProt protein ID

Q9Y6H5

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6H5

determination method or standard

IPI

retrieved

8 April 2019

stated in

Parkin accumulation in aggresomes due to proteasome impairment

GOA

curator

UniProt

UniProt protein ID

Q9Y6H5

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6H5

determination method or standard

IPI

retrieved

8 April 2019

stated in

Synphilin-1 is developmentally localized to synaptic terminals, and its association with synaptic vesicles is modulated by alpha-synuclein

GOA

curator

UniProt

UniProt protein ID

Q9Y6H5

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6H5

determination method or standard

IPI

retrieved

8 April 2019

stated in

Synphilin-1 associates with alpha-synuclein and promotes the formation of cytosolic inclusions

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6H5

determination method or standard

IPI

retrieved

8 April 2019

stated in

Analysis of synphilin-1 and synuclein interactions by yeast two-hybrid beta-galactosidase liquid assay

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6H5

determination method or standard

IPI

retrieved

8 April 2019

stated in

Interaction with synphilin-1 promotes inclusion formation of alpha-synuclein: mechanistic insights and pathological implication

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6H5

determination method or standard

IPI

ubiquitin protein ligase binding

determination method or standard

IPI

1 reference

retrieved

8 April 2019

stated in

Parkin mediates nonclassical, proteasomal-independent ubiquitination of synphilin-1: implications for Lewy body formation

GOA

curator

UniProt

UniProt protein ID

Q9Y6H5

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6H5

determination method or standard

IPI

identical protein binding

determination method or standard

IPI

1 reference

retrieved

8 April 2019

stated in

Interaction with synphilin-1 promotes inclusion formation of alpha-synuclein: mechanistic insights and pathological implication

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6H5

determination method or standard

IPI

cell component

cytoplasm

determination method or standard

IDA

IEA

TAS

3 references

retrieved

8 April 2019

stated in

Synphilin-1 associates with alpha-synuclein and promotes the formation of cytosolic inclusions

GOA

curator

Proteome Inc.

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6H5

determination method or standard

TAS

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q9Y6H5

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6H5

determination method or standard

IEA

retrieved

8 April 2019

stated in

Siah-1 facilitates ubiquitination and degradation of synphilin-1

GOA

curator

Mouse Genome Informatics

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6H5

determination method or standard

IDA

cytosol

determination method or standard

TAS

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6H5

determination method or standard

TAS

soma

determination method or standard

NAS

1 reference

retrieved

8 April 2019

stated in

Synphilin-1 is developmentally localized to synaptic terminals, and its association with synaptic vesicles is modulated by alpha-synuclein

GOA

curator

UniProt

UniProt protein ID

Q9Y6H5

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6H5

determination method or standard

NAS

presynaptic membrane

determination method or standard

NAS

1 reference

retrieved

8 April 2019

stated in

Synphilin-1 is developmentally localized to synaptic terminals, and its association with synaptic vesicles is modulated by alpha-synuclein

GOA

curator

UniProt

UniProt protein ID

Q9Y6H5

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6H5

determination method or standard

NAS

synaptic vesicle

determination method or standard

TAS

1 reference

retrieved

8 April 2019

stated in

Synaptic vesicle trafficking and Parkinson's disease

GOA

curator

Parkinsons Disease Gene Ontology Initiative

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6H5

determination method or standard

TAS

nucleoplasm

determination method or standard

IDA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Human Protein Atlas

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6H5

determination method or standard

IDA

cytoplasmic ribonucleoprotein granule

determination method or standard

IDA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Human Protein Atlas

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6H5

determination method or standard

IDA

biological process

regulation of inclusion body assembly

determination method or standard

IDA

1 reference

retrieved

8 April 2019

stated in

BAG5 inhibits parkin and enhances dopaminergic neuron degeneration

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6H5

determination method or standard

IDA

dopamine metabolic process

determination method or standard

IDA

1 reference

retrieved

8 April 2019

stated in

Siah-1 facilitates ubiquitination and degradation of synphilin-1

GOA

curator

Mouse Genome Informatics

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6H5

determination method or standard

IDA

cell death

determination method or standard

IDA

1 reference

retrieved

8 April 2019

stated in

Synphilin-1A: an aggregation-prone isoform of synphilin-1 that causes neuronal death and is present in aggregates from alpha-synucleinopathy patients

GOA

curator

Community Assessment of Community Annotation with Ontologies

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6H5

determination method or standard

IDA

regulation of neurotransmitter secretion

determination method or standard

IDA

1 reference

retrieved

8 April 2019

stated in

Siah-1 facilitates ubiquitination and degradation of synphilin-1

GOA

curator

Mouse Genome Informatics

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6H5

determination method or standard

IDA

Identifiers

RefSeq protein ID

NP_001229864

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

9627

NP_001295029

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

9627

NP_001295034

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

9627

NP_001295035

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

9627

NP_001295036

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

9627

NP_001295037

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

9627

NP_001295038

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

9627

NP_005451

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

9627

XP_005272195

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

9627

XP_005272196

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

9627

XP_006714797

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

9627

XP_011542039

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

9627

XP_011542040

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

9627

XP_011542041

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

9627

XP_011542043

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

9627

XP_011542045

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

9627

XP_011542047

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

9627

XP_011542051

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

9627

XP_011542052

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

9627

XP_016865567

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

9627

XP_016865568

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

9627

XP_016865569

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

9627

XP_016865570

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

9627

XP_016865571

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

9627

XP_016865572

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

9627

XP_016865573

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

9627

XP_016865574

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

9627

XP_016865575

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

9627

XP_024302034

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

9627

XP_024302035

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

9627

XP_024302036

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

9627

XP_024302037

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

9627

UniProt protein ID

Q9Y6H5

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

Q9Y6H5

Ensembl protein ID

ENSP00000261367

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000261367

ENSP00000261368

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000261368

ENSP00000368854

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000368854

ENSP00000378852

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000378852

ENSP00000378849

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000378849

ENSP00000394392

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000394392

ENSP00000422106

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000422106

ENSP00000422610

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000422610

ENSP00000423360

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000423360

ENSP00000424338

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000424338

ENSP00000425063

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000425063

ENSP00000426280

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000426280

ENSP00000426526

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000426526

ENSP00000426551

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000426551

ENSP00000426904

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000426904

ENSP00000427078

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000427078

ENSP00000427090

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000427090

ENSP00000427575

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000427575

ENSP00000427587

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000427587

ENSP00000441681

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000441681

PDB structure ID

2KES

1 reference

stated in

UniProt

UniProt protein ID

Q9Y6H5

retrieved

20 March 2016

language of work or name

English

 

Sitelinks

Wikipedia(0 entries)

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Wikibooks(0 entries)

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Wikinews(0 entries)

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Wikiquote(0 entries)

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Wikisource(0 entries)

edit

Wikiversity(0 entries)

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Wikivoyage(0 entries)

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Wiktionary(0 entries)

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Multilingual sites(0 entries)

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Retrieved from "https://www.wikidata.org/w/index.php?title=Q21127234&oldid=2023010901"