Interleukin 1 receptor type 1 (Q21117797)

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mammalian protein found in Homo sapiens

• IL-1R-alpha
• IL-1RT-1
• p80
• IL-1RT1
• interleukin-1 receptor type I
• IL1R1
• CD121 antigen-like family member A
• interleukin-1 receptor type 1
• interleukin 1 receptor alpha, type I
• interleukin-1 receptor alpha
• IL-1R-1

edit

Language	Label	Description	Also known as
English	Interleukin 1 receptor type 1	mammalian protein found in Homo sapiens	IL-1R-alpha IL-1RT-1 p80 IL-1RT1 interleukin-1 receptor type I IL1R1 CD121 antigen-like family member A interleukin-1 receptor type 1 interleukin 1 receptor alpha, type I interleukin-1 receptor alpha IL-1R-1

Statements

instance of

protein

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

P14778

part of

Toll/interleukin-1 receptor homology (TIR) domain superfamily

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/P14778

Immunoglobulin-like fold

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/P14778

interleukin-1 receptor type 1

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/P14778

Immunoglobulin-like domain superfamily

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/P14778

interleukin-1 receptor family

1 reference

Transporter Classification Database ID

8.A.23.1.11

retrieved

2 October 2019

based on heuristic

hierarchical database ID heuristic

Immunoglobulin subtype, protein family

1 reference

based on heuristic

inferred from protein domain or family

Toll/interleukin-1 receptor homology (TIR) domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

immunoglobulin-like domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

found in taxon

Homo sapiens

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

P14778

encoded by

IL1R1

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

P14778

molecular function

interleukin-1, type I, activating receptor activity

determination method or standard

IEA

TAS

2 references

retrieved

9 May 2019

stated in

Receptor induction regulates the synergistic effects of substance P with IL-1 and platelet-derived growth factor on the proliferation of bone marrow fibroblasts

GOA

curator

Proteome Inc.

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14778

determination method or standard

TAS

retrieved

9 May 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14778

determination method or standard

IEA

signal transducer activity

determination method or standard

TAS

IEA

3 references

retrieved

31 January 2018

stated in

Receptor induction regulates the synergistic effects of substance P with IL-1 and platelet-derived growth factor on the proliferation of bone marrow fibroblasts

GOA

curator

Proteome Inc.

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P14778&geneProductId=UniProtKB:P14778

determination method or standard

TAS

retrieved

31 January 2018

stated in

Cloning the interleukin 1 receptor from human T cells

GOA

curator

Proteome Inc.

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P14778&geneProductId=UniProtKB:P14778

determination method or standard

TAS

retrieved

31 January 2018

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P14778&geneProductId=UniProtKB:P14778

determination method or standard

IEA

platelet-derived growth factor receptor binding

determination method or standard

IPI

1 reference

retrieved

9 May 2019

stated in

Synergistic roles of platelet-derived growth factor-BB and interleukin-1beta in phenotypic modulation of human aortic smooth muscle cells

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14778

determination method or standard

IPI

protease binding

determination method or standard

IEA

1 reference

retrieved

9 May 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14778

determination method or standard

IEA

protein binding

determination method or standard

IPI

3 references

retrieved

9 May 2019

stated in

Synergistic roles of platelet-derived growth factor-BB and interleukin-1beta in phenotypic modulation of human aortic smooth muscle cells

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14778

determination method or standard

IPI

retrieved

9 May 2019

stated in

Interleukin-1beta induction of NFkappaB is partially regulated by H2O2-mediated activation of NFkappaB-inducing kinase

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14778

determination method or standard

IPI

retrieved

9 May 2019

stated in

SIGIRR, a negative regulator of Toll-like receptor-interleukin 1 receptor signaling

GOA

curator

HUGO Gene Nomenclature Committee

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14778

determination method or standard

IPI

transmembrane signaling receptor activity

determination method or standard

TAS

1 reference

retrieved

9 May 2019

stated in

Cloning the interleukin 1 receptor from human T cells

GOA

curator

Proteome Inc.

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14778

determination method or standard

TAS

interleukin-1 receptor activity

determination method or standard

IDA

IEA

TAS

4 references

retrieved

8 April 2019

stated in

Interleukin-1 receptor cluster: gene organization of IL1R2, IL1R1, IL1RL2 (IL-1Rrp2), IL1RL1 (T1/ST2), and IL18R1 (IL-1Rrp) on human chromosome 2q

GOA

curator

Proteome Inc.

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14778

determination method or standard

TAS

retrieved

8 April 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14778

determination method or standard

IEA

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14778

determination method or standard

IEA

retrieved

8 April 2019

stated in

IRAK-M is a novel member of the Pelle/interleukin-1 receptor-associated kinase (IRAK) family

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14778

determination method or standard

IDA

interleukin-1 binding

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14778

determination method or standard

IEA

interleukin-1 receptor activity

determination method or standard

IBA

IDA

IEA

TAS

5 references

retrieved

9 May 2019

stated in

Interleukin-1 receptor cluster: gene organization of IL1R2, IL1R1, IL1RL2 (IL-1Rrp2), IL1RL1 (T1/ST2), and IL18R1 (IL-1Rrp) on human chromosome 2q

GOA

curator

Proteome Inc.

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14778

determination method or standard

TAS

retrieved

9 May 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14778

determination method or standard

IEA

retrieved

9 May 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14778

determination method or standard

IEA

retrieved

9 May 2019

stated in

IRAK-M is a novel member of the Pelle/interleukin-1 receptor-associated kinase (IRAK) family

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14778

determination method or standard

IDA

retrieved

9 May 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14778

determination method or standard

IBA

interleukin-1 binding

determination method or standard

IBA

IEA

2 references

retrieved

9 May 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14778

determination method or standard

IEA

retrieved

9 May 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14778

determination method or standard

IBA

cell component

integral component of membrane

determination method or standard

IEA

1 reference

retrieved

9 May 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P14778

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14778

determination method or standard

IEA

membrane

determination method or standard

IDA

IEA

2 references

retrieved

9 May 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P14778

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14778

determination method or standard

IEA

retrieved

9 May 2019

stated in

Synergistic roles of platelet-derived growth factor-BB and interleukin-1beta in phenotypic modulation of human aortic smooth muscle cells

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14778

determination method or standard

IDA

plasma membrane

determination method or standard

TAS

IEA

2 references

retrieved

9 May 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14778

determination method or standard

TAS

retrieved

9 May 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P14778

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14778

determination method or standard

IEA

integral component of plasma membrane

determination method or standard

TAS

1 reference

retrieved

9 May 2019

stated in

Cloning the interleukin 1 receptor from human T cells

GOA

curator

Proteome Inc.

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14778

determination method or standard

TAS

extracellular region

determination method or standard

IEA

1 reference

retrieved

9 May 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P14778

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14778

determination method or standard

IEA

cell surface

determination method or standard

IEA

1 reference

retrieved

9 May 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14778

determination method or standard

IEA

external side of plasma membrane

determination method or standard

IEA

1 reference

retrieved

9 May 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14778

determination method or standard

IEA

biological process

cell surface receptor signaling pathway

determination method or standard

TAS

1 reference

retrieved

9 May 2019

stated in

A novel IL-1 receptor, cloned from B cells by mammalian expression, is expressed in many cell types

GOA

curator

Proteome Inc.

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14778

determination method or standard

TAS

immune response

determination method or standard

TAS

1 reference

retrieved

9 May 2019

stated in

Receptor induction regulates the synergistic effects of substance P with IL-1 and platelet-derived growth factor on the proliferation of bone marrow fibroblasts

GOA

curator

Proteome Inc.

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14778

determination method or standard

TAS

regulation of inflammatory response

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14778

determination method or standard

IEA

signal transduction

determination method or standard

IEA

1 reference

retrieved

9 May 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14778

determination method or standard

IEA

positive regulation of interleukin-1-mediated signaling pathway

determination method or standard

IEA

1 reference

retrieved

9 May 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14778

determination method or standard

IEA

positive regulation of neutrophil extravasation

determination method or standard

IEA

1 reference

retrieved

9 May 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14778

determination method or standard

IEA

response to interleukin-1

determination method or standard

IDA

1 reference

retrieved

9 May 2019

stated in

IRAK-M is a novel member of the Pelle/interleukin-1 receptor-associated kinase (IRAK) family

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14778

determination method or standard

IDA

cytokine-mediated signaling pathway

determination method or standard

IEA

TAS

2 references

retrieved

9 May 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14778

determination method or standard

TAS

retrieved

9 May 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14778

determination method or standard

IEA

interleukin-1-mediated signaling pathway

determination method or standard

IDA

TAS

2 references

retrieved

8 April 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14778

determination method or standard

TAS

retrieved

8 April 2019

stated in

IRAK-M is a novel member of the Pelle/interleukin-1 receptor-associated kinase (IRAK) family

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14778

determination method or standard

IDA

positive regulation of interferon-gamma production

determination method or standard

IDA

1 reference

retrieved

9 May 2019

stated in

IL-12 synergizes with IL-18 or IL-1beta for IFN-gamma production from human T cells

GOA

curator

UniProt

UniProt protein ID

P14778

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14778

determination method or standard

IDA

positive regulation of T-helper 1 cell cytokine production

determination method or standard

IDA

1 reference

retrieved

9 May 2019

stated in

IL-12 synergizes with IL-18 or IL-1beta for IFN-gamma production from human T cells

GOA

curator

UniProt

UniProt protein ID

P14778

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14778

determination method or standard

IDA

inflammatory response

determination method or standard

IEA

1 reference

retrieved

9 May 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P14778

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14778

determination method or standard

IEA

regulation of inflammatory response

determination method or standard

IBA

IEA

2 references

retrieved

9 May 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14778

determination method or standard

IEA

retrieved

9 May 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14778

determination method or standard

IBA

interleukin-1-mediated signaling pathway

determination method or standard

IBA

IDA

TAS

3 references

retrieved

9 May 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14778

determination method or standard

TAS

retrieved

9 May 2019

stated in

IRAK-M is a novel member of the Pelle/interleukin-1 receptor-associated kinase (IRAK) family

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14778

determination method or standard

IDA

retrieved

9 May 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14778

determination method or standard

IBA

has part(s)

immunoglobulin-like domain

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/P14778

Toll/interleukin-1 receptor homology (TIR) domain

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/P14778

immunoglobulin subtype

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/P14778

Commons category

Type-1 interleukin-1 receptor

0 references

Identifiers

RefSeq protein ID

NP_000868

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

3554

NP_001275635

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

3554

NP_001307907

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

3554

NP_001307909

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

3554

NP_001307910

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

3554

NP_001307911

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

3554

NP_001307912

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

3554

NP_001307913

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

3554

NP_001307914

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

3554

NP_001307915

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

3554

XP_005263987

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

3554

XP_005263991

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

3554

XP_011509417

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

3554

XP_011509418

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

3554

XP_011509419

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

3554

XP_011509420

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

3554

XP_016859478

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

3554

UniProt protein ID

P14778

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

P14778

Ensembl protein ID

ENSP00000386380

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000386380

ENSP00000386478

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000386478

ENSP00000386555

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000386555

ENSP00000386776

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000386776

ENSP00000387131

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000387131

ENSP00000390349

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000390349

ENSP00000393296

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000393296

ENSP00000401646

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000401646

ENSP00000407017

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000407017

ENSP00000408101

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000408101

ENSP00000410461

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000410461

ENSP00000411627

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000411627

ENSP00000415366

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000415366

Freebase ID

/m/03gwpp7

0 references

Microsoft Academic ID

10775765

0 references

OpenAlex ID

C10775765

1 reference

stated in

OpenAlex

retrieved

26 January 2022

reference URL

https://docs.openalex.org/download-snapshot/snapshot-data-format

PDB structure ID

1G0Y

1 reference

stated in

UniProt

UniProt protein ID

P14778

retrieved

9 August 2016

language of work or name

English

1IRA

1 reference

stated in

UniProt

UniProt protein ID

P14778

retrieved

9 August 2016

language of work or name

English

1ITB

1 reference

stated in

UniProt

UniProt protein ID

P14778

retrieved

9 August 2016

language of work or name

English

4DEP

1 reference

stated in

UniProt

UniProt protein ID

P14778

retrieved

9 August 2016

language of work or name

English

4GAF

1 reference

stated in

UniProt

UniProt protein ID

P14778

retrieved

9 August 2016

language of work or name

English

Transporter Classification Database ID

8.A.23.1.11

2 references

stated in

Transporter Classification database

retrieved

13 March 2020

stated in

Transporter Classification database

retrieved

29 April 2020

 

Sitelinks

Wikipedia(4 entries)

edit

• cywiki IL1R1
• dewiki Interleukin-1-Rezeptor Typ 1
• enwiki Interleukin 1 receptor, type I
• ukwiki IL1R1

Wikibooks(0 entries)

edit

Wikinews(0 entries)

edit

Wikiquote(0 entries)

edit

Wikisource(0 entries)

edit

Wikiversity(0 entries)

edit

Wikivoyage(0 entries)

edit

Wiktionary(0 entries)

edit

Multilingual sites(1 entry)

edit

• commonswiki Category:Type-1 interleukin-1 receptor

Retrieved from "https://www.wikidata.org/w/index.php?title=Q21117797&oldid=2022971190"