Type 2 diabetes as an inflammatory disease (Q29617184)

title

Type 2 diabetes as an inflammatory disease (English)

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=21233852

30 April 2017

0 references

0 references

Marc Y. Donath

1 reference

21233852

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21233852

22 November 2024

Steven E. Shoelson

series ordinal

1 reference

21233852

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21233852

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=21233852

22 November 2024

language of work or name

1 reference

30 April 2017

publication date

February 2011

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=21233852

30 April 2017

14 January 2011

1 reference

21233852

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21233852

full work available at URL

22 November 2024

https://www.nature.com/articles/nri2925.pdf

file format

Portable Document Format

1 reference

https://www.nature.com/articles/nri2925

22 November 2024

1 reference

Nature Reviews Immunology

22 November 2024

published in

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=21233852

30 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=21233852

30 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=21233852

30 April 2017

page(s)

98-107

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=21233852

Inflammation and insulin resistance

30 April 2017

cites work

1 reference

Islet inflammation impairs the pancreatic beta-cell in type 2 diabetes.

31 March 2020

1 reference

Islet growth and development in the adult

31 March 2020

1 reference

Type 2 diabetes: when insulin secretion fails to compensate for insulin resistance

31 March 2020

1 reference

Type 2 diabetes-a matter of beta-cell life and death?

31 March 2020

1 reference

Beta-cell glucose toxicity, lipotoxicity, and chronic oxidative stress in type 2 diabetes

31 March 2020

1 reference

Five stages of evolving beta-cell dysfunction during progression to diabetes

31 March 2020

1 reference

Islet beta cell failure in type 2 diabetes

31 March 2020

1 reference

Islet amyloid: a critical entity in the pathogenesis of type 2 diabetes

31 March 2020

1 reference

Endoplasmic reticulum stress and the development of diabetes: a review

31 March 2020

1 reference

Nutrient sensing and inflammation in metabolic diseases

31 March 2020

1 reference

Inflammatory mediators and islet beta-cell failure: a link between type 1 and type 2 diabetes

31 March 2020

1 reference

Pancreatic islet inflammation in type 2 diabetes: from alpha and beta cell compensation to dysfunction.

31 March 2020

1 reference

Islet inflammation in type 2 diabetes: from metabolic stress to therapy.

31 March 2020

1 reference

Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes

31 March 2020

1 reference

NIDDM as a disease of the innate immune system: association of acute-phase reactants and interleukin-6 with metabolic syndrome X.

31 March 2020

1 reference

Inflammatory cytokines and the risk to develop type 2 diabetes: results of the prospective population-based European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam Study

31 March 2020

1 reference

Inflammation and type 2 diabetes: results from KORA Augsburg

31 March 2020

1 reference

Elevated levels of the anti-inflammatory interleukin-1 receptor antagonist precede the onset of type 2 diabetes: the Whitehall II study

31 March 2020

1 reference

C-reactive protein, interleukin 6, and risk of developing type 2 diabetes mellitus

31 March 2020

1 reference

IL-1 receptor antagonist serum levels are increased in human obesity: a possible link to the resistance to leptin?

31 March 2020

1 reference

Accelerated increase in serum interleukin-1 receptor antagonist starts 6 years before diagnosis of type 2 diabetes: Whitehall II prospective cohort study

31 March 2020

1 reference

Interleukin-1 receptor antagonist genotype is associated with coronary atherosclerosis in patients with type 2 diabetes

31 March 2020

1 reference

The role of the interleukin-1-receptor antagonist in blocking inflammation mediated by interleukin-1.

31 March 2020

1 reference

Interleukin-1-receptor antagonist in type 2 diabetes mellitus

31 March 2020

1 reference

IL-1 antagonism reduces hyperglycemia and tissue inflammation in the type 2 diabetic GK rat

31 March 2020

1 reference

The effects of salsalate on glycemic control in patients with type 2 diabetes: a randomized trial

31 March 2020

1 reference

Adipose Expression of Tumor Necrosis Factor-α: Direct Role in Obesity-Linked Insulin Resistance

31 March 2020

1 reference

Obesity and diabetes in TNF-alpha receptor- deficient mice

31 March 2020

1 reference

Effects of etanercept in patients with the metabolic syndrome

31 March 2020

1 reference

Metabolic and vascular effects of tumor necrosis factor-alpha blockade with etanercept in obese patients with type 2 diabetes

31 March 2020

1 reference

Effects of TNF-alpha neutralization on adipocytokines and skeletal muscle adiposity in the metabolic syndrome

31 March 2020

1 reference

Effects of an engineered human anti-TNF-alpha antibody (CDP571) on insulin sensitivity and glycemic control in patients with NIDDM.

31 March 2020

1 reference

Insulin resistance in patients with rheumatoid arthritis: effect of anti-TNFalpha therapy.

31 March 2020

1 reference

Effects of infliximab treatment on insulin resistance in patients with rheumatoid arthritis and ankylosing spondylitis

31 March 2020

1 reference

TNF-α Antagonism with Etanercept Decreases Glucose and Increases the Proportion of High Molecular Weight Adiponectin in Obese Subjects with Features of the Metabolic Syndrome

31 March 2020

1 reference

Relapse of diabetes after interruption of chronic administration of anti-tumor necrosis factor-alpha antibody infliximab: a case observation

31 March 2020

1 reference

Improvement of insulin sensitivity in insulin resistant subjects during prolonged treatment with the anti-TNF-alpha antibody infliximab

31 March 2020

1 reference

Obesity is associated with macrophage accumulation in adipose tissue

31 March 2020

1 reference

Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance

31 March 2020

1 reference

Increased Inflammatory Properties of Adipose Tissue Macrophages Recruited During Diet-Induced Obesity

31 March 2020

1 reference

Dynamic, M2-like remodeling phenotypes of CD11c+ adipose tissue macrophages during high-fat diet--induced obesity in mice

31 March 2020

1 reference

Weight loss and lipolysis promote a dynamic immune response in murine adipose tissue

31 March 2020

1 reference

Inflammation and adipose tissue macrophages in lipodystrophic mice

31 March 2020

1 reference

Obesity induces a phenotypic switch in adipose tissue macrophage polarization

31 March 2020

1 reference

Genetic deficiency and pharmacological stabilization of mast cells reduce diet-induced obesity and diabetes in mice

31 March 2020

1 reference

T-cell accumulation and regulated on activation, normal T cell expressed and secreted upregulation in adipose tissue in obesity

31 March 2020

1 reference

Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters

31 March 2020

1 reference

Induction of regulatory T cells decreases adipose inflammation and alleviates insulin resistance in ob/ob mice

31 March 2020

1 reference

Human regulatory T cells and their role in autoimmune disease

31 March 2020

1 reference

Regulatory T-cell immunotherapy for tolerance to self antigens and alloantigens in humans.

31 March 2020

1 reference

Leptin modulates beta cell expression of IL-1 receptor antagonist and release of IL-1beta in human islets

31 March 2020

1 reference

Glucose-induced beta cell production of IL-1beta contributes to glucotoxicity in human pancreatic islets

31 March 2020

1 reference

Increased number of islet-associated macrophages in type 2 diabetes.

31 March 2020

1 reference

Angiogenesis in life, disease and medicine

31 March 2020

1 reference

Adipose tissue hypoxia in obesity and its impact on adipocytokine dysregulation

31 March 2020

1 reference

Role of hypoxia in obesity-induced disorders of glucose and lipid metabolism in adipose tissue

31 March 2020

1 reference

Reduced oxygenation in human obese adipose tissue is associated with impaired insulin suppression of lipolysis

31 March 2020

1 reference

Reduced adipose tissue oxygenation in human obesity: evidence for rarefaction, macrophage chemotaxis, and inflammation without an angiogenic response

31 March 2020

1 reference

Hypoxia regulates macrophage functions in inflammation.

31 March 2020

1 reference

Hypoxia-induced gene expression in human macrophages: implications for ischemic tissues and hypoxia-regulated gene therapy

31 March 2020

1 reference

Adipocyte death defines macrophage localization and function in adipose tissue of obese mice and humans

31 March 2020

1 reference

Adipocyte death, adipose tissue remodeling, and obesity complications

31 March 2020

1 reference

IKK-beta links inflammation to obesity-induced insulin resistance

31 March 2020

1 reference

Local and systemic insulin resistance resulting from hepatic activation of IKK-beta and NF-kappaB

31 March 2020

1 reference

JNK1 and IKKbeta: molecular links between obesity and metabolic dysfunction

31 March 2020

1 reference

TLR4 links innate immunity and fatty acid-induced insulin resistance

31 March 2020

1 reference

A stress signaling pathway in adipose tissue regulates hepatic insulin resistance

31 March 2020

1 reference

JNK1 in hematopoietically derived cells contributes to diet-induced inflammation and insulin resistance without affecting obesity

31 March 2020

1 reference

Functional in vivo interactions between JNK1 and JNK2 isoforms in obesity and insulin resistance

31 March 2020

1 reference

IKKbeta/NF-kappaB activation causes severe muscle wasting in mice

31 March 2020

1 reference

Hypothalamic IKKbeta/NF-kappaB and ER stress link overnutrition to energy imbalance and obesity

31 March 2020

1 reference

Conditional and specific NF-kappaB blockade protects pancreatic beta cells from diabetogenic agents.

31 March 2020

1 reference

Counterpoint: Interleukin-6 does not have a beneficial role in insulin sensitivity and glucose homeostasis

31 March 2020

1 reference

Interleukin-6 does/does not have a beneficial role in insulin sensitivity and glucose homeostasis

31 March 2020

1 reference

Interleukin-6 signaling in liver-parenchymal cells suppresses hepatic inflammation and improves systemic insulin action

31 March 2020

1 reference

Interleukin-6-deficient mice develop hepatic inflammation and systemic insulin resistance

31 March 2020

1 reference

Hyperglycemia-induced beta-cell apoptosis in pancreatic islets of Psammomys obesus during development of diabetes.

31 March 2020

1 reference

Glucose induces beta-cell apoptosis via upregulation of the Fas receptor in human islets

31 March 2020

1 reference

The Fas pathway is involved in pancreatic beta cell secretory function

31 March 2020

1 reference

Increased interleukin (IL)-1beta messenger ribonucleic acid expression in beta -cells of individuals with type 2 diabetes and regulation of IL-1beta in human islets by glucose and autostimulation.

31 March 2020

1 reference

Free fatty acids induce a proinflammatory response in islets via the abundantly expressed interleukin-1 receptor I.

31 March 2020

1 reference

Toll-like receptor 2-deficient mice are protected from insulin resistance and beta cell dysfunction induced by a high-fat diet.

31 March 2020

1 reference

Induction of proinflammatory cytokines by long-chain saturated fatty acids in human macrophages

31 March 2020

1 reference

Saturated fatty acids, but not unsaturated fatty acids, induce the expression of cyclooxygenase-2 mediated through Toll-like receptor 4.

31 March 2020

1 reference

Saturated fatty acid activates but polyunsaturated fatty acid inhibits Toll-like receptor 2 dimerized with Toll-like receptor 6 or 1.

31 March 2020

1 reference

Thioredoxin-interacting protein links oxidative stress to inflammasome activation

31 March 2020

1 reference

Reactive oxygen species-independent activation of the IL-1beta inflammasome in cells from patients with chronic granulomatous disease

31 March 2020

1 reference

Inflammasome activation in NADPH oxidase defective mononuclear phagocytes from patients with chronic granulomatous disease

31 March 2020

1 reference

The NLRP3 inflammasome: a sensor for metabolic danger?

31 March 2020

1 reference

Monocyte chemoattractant protein-1 release is higher in visceral than subcutaneous human adipose tissue (AT): implication of macrophages resident in the AT.

31 March 2020

1 reference

Macrophage infiltration into omental versus subcutaneous fat across different populations: effect of regional adiposity and the comorbidities of obesity

31 March 2020

1 reference

MCP-1 contributes to macrophage infiltration into adipose tissue, insulin resistance, and hepatic steatosis in obesity

31 March 2020

1 reference

Monocyte chemoattractant protein 1 in obesity and insulin resistance

31 March 2020

1 reference

Overexpression of monocyte chemoattractant protein-1 in adipose tissues causes macrophage recruitment and insulin resistance

31 March 2020

1 reference

31 March 2020

1 reference

Adiponectin induces the anti-inflammatory cytokines IL-10 and IL-1RA in human leukocytes

31 March 2020

1 reference

Local inflammation and hypoxia abolish the protective anticontractile properties of perivascular fat in obese patients.

31 March 2020

1 reference

Mechanisms of obesity and related pathologies: the macro- and microcirculation of adipose tissue

31 March 2020

1 reference

Salsalate improves glycemia and inflammatory parameters in obese young adults

31 March 2020

1 reference

Sustained effects of interleukin-1 receptor antagonist treatment in type 2 diabetes.

31 March 2020

1 reference

Insulin resistance in rheumatoid arthritis: the impact of the anti-TNF-alpha therapy

31 March 2020

1 reference

Improved insulin sensitivity by anti-TNFalpha antibody treatment in patients with rheumatic diseases

31 March 2020

1 reference

Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of Ikkbeta

31 March 2020

1 reference

The effect of sodium salicylate and aspirin on NF-kappa B

31 March 2020

1 reference

Effect of sodium salicylate on the human heat shock response

31 March 2020

1 reference

Mechanism by which high-dose aspirin improves glucose metabolism in type 2 diabetes

31 March 2020

1 reference

Partial pancreatectomy in the rat and subsequent defect in glucose-induced insulin release

31 March 2020

1 reference

Chronic hyperglycemia is associated with impaired glucose influence on insulin secretion. A study in normal rats using chronic in vivo glucose infusions

31 March 2020

1 reference

Hyperglycemia decreases glucose uptake in type I diabetes.

31 March 2020

1 reference

Correction of hyperglycemia with phlorizin normalizes tissue sensitivity to insulin in diabetic rats

31 March 2020

1 reference

Measurement of plasma glucose, free fatty acid, lactate, and insulin for 24 h in patients with NIDDM.

31 March 2020

1 reference

Body fat distribution and non-insulin-dependent diabetes: comparison of a fiber-rich, high-carbohydrate, low-fat (23%) diet and a 35% fat diet high in monounsaturated fat

31 March 2020

1 reference

Monounsaturated fatty acids prevent the deleterious effects of palmitate and high glucose on human pancreatic beta-cell turnover and function

31 March 2020

1 reference

Distinct effects of saturated and monounsaturated fatty acids on beta-cell turnover and function

31 March 2020

1 reference

Lipotoxicity in the pathogenesis of obesity-dependent NIDDM. Genetic and clinical implications.

31 March 2020

1 reference

Are the beta-cell signaling molecules malonyl-CoA and cystolic long-chain acyl-CoA implicated in multiple tissue defects of obesity and NIDDM?

31 March 2020

1 reference

Lipid homeostasis, lipotoxicity and the metabolic syndrome.

31 March 2020

1 reference

Glucolipotoxicity: fuel excess and beta-cell dysfunction.

31 March 2020

1 reference

Oxidative stress and stress-activated signaling pathways: a unifying hypothesis of type 2 diabetes

31 March 2020

1 reference

Are oxidative stress-activated signaling pathways mediators of insulin resistance and beta-cell dysfunction?

31 March 2020

1 reference

Endoplasmic reticulum stress and diabetes mellitus.

31 March 2020

1 reference

Dominant negative pathogenesis by mutant proinsulin in the Akita diabetic mouse

31 March 2020

1 reference

Endoplasmic reticulum stress and the inflammatory basis of metabolic disease

31 March 2020

1 reference

Toxic oligomers and islet beta cell death: guilty by association or convicted by circumstantial evidence?

31 March 2020

1 reference

Diagnosis and Classification of Diabetes Mellitus

31 March 2020

1 reference

Testing the accelerator hypothesis: the relationship between body mass and age at diagnosis of type 1 diabetes

31 March 2020

1 reference

The accelerator hypothesis: weight gain as the missing link between Type I and Type II diabetes

31 March 2020

1 reference

Decreased beta-cell mass in diabetes: significance, mechanisms and therapeutic implications

31 March 2020

1 reference

Obesity, increased linear growth, and risk of type 1 diabetes in children

31 March 2020

1 reference

Changing Prevalence of Overweight Children and Adolescents at Onset of Insulin-Treated Diabetes

31 March 2020

1 reference

Insulin resistance is a risk factor for progression to type 1 diabetes

31 March 2020

1 reference

Medical management of hyperglycemia in type 2 diabetes: a consensus algorithm for the initiation and adjustment of therapy: a consensus statement of the American Diabetes Association and the European Association for the Study of Diabetes

31 March 2020

1 reference

Type 1, type 1.5, and type 2 diabetes: NOD the diabetes we thought it was

31 March 2020

1 reference

Use of salsalate to target inflammation in the treatment of insulin resistance and type 2 diabetes

31 March 2020

1 reference

The effect of salsalate on insulin action and glucose tolerance in obese non-diabetic patients: results of a randomised double-blind placebo-controlled study.

31 March 2020

1 reference

No increased insulin sensitivity after a single intravenous administration of a recombinant human tumor necrosis factor receptor: Fc fusion protein in obese insulin-resistant patients

31 March 2020

1 reference

12 December 2020

Biologic basis for interleukin-1 in disease

1 reference

12 December 2020

Omental and subcutaneous adipose tissues of obese subjects release interleukin-6: depot difference and regulation by glucocorticoid

1 reference

12 December 2020

Anti-tumor necrosis factor-alpha blockade improves insulin resistance in patients with rheumatoid arthritis

1 reference

12 December 2020

The Journal of Clinical Endocrinology and Metabolism

1316

N Paquot

2000

1 reference

The Journal of Clinical Endocrinology and Metabolism

22 November 2024

847

SK Fried

1998

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=21233852

22 November 2024

Identifiers

2 references

30 April 2017

Consolidated OpenCitations Corpus – April 2017

Dimensions Publication ID

1041192648

0 references

1 reference

Consolidated OpenCitations Corpus – April 2017

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=21233852

2 references

30 April 2017

Consolidated OpenCitations Corpus – April 2017