A family with severe insulin resistance and diabetes due to a mutation in AKT2. (Q36481707)

14 August 2017

A family with severe insulin resistance and diabetes due to a mutation in AKT2. (English)

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14 August 2017

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1 reference

Inês Barroso

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Justin J Rochford

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Carlo L Acerini

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David B Dunger

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Stephen O'Rahilly

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Nicholas J Wareham

1 reference

14 August 2017

Christian Wolfrum

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14 August 2017

Stella George

1 reference

14 August 2017

Sarah L Gray

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14 August 2017

Sven Schinner

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14 August 2017

Jenny C Wilson

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14 August 2017

Maria A Soos

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14 August 2017

Peter R Murgatroyd

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14 August 2017

Rachel M Williams

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14 August 2017

David Barford

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14 August 2017

A Margot Umpleby

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14 August 2017

Huw Alban Davies

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14 August 2017

Alan J Schafer

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14 August 2017

Markus Stoffel

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14 August 2017

language of work or name

English

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publication date

1 May 2004

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14 August 2017

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inferred from page(s)

published in

Science

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14 August 2017

304

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14 August 2017

5675

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14 August 2017

1325-1328

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Insulin regulates the activity of forkhead transcription factor Hnf-3beta/Foxa-2 by Akt-mediated phosphorylation and nuclear/cytosolic localization.

14 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2258004

Severe diabetes, age-dependent loss of adipose tissue, and mild growth deficiency in mice lacking Akt2/PKB beta

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2258004

Molecular pathogenesis of inherited hypertension with hyperkalemia: the Na-Cl cotransporter is inhibited by wild-type but not mutant WNK4

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2258004

Crystal structure of an activated Akt/protein kinase B ternary complex with GSK3-peptide and AMP-PNP

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2258004

Molecular diagnostics in monogenic and multifactorial forms of type 2 diabetes

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2258004

Ten years of protein kinase B signalling: a hard Akt to follow

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2258004

Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKB beta)

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2258004

Transcriptional control of adipogenesis

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2258004

The PI3K-PDK1 connection: more than just a road to PKB

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2258004

Dominant negative mutations in human PPARgamma associated with severe insulin resistance, diabetes mellitus and hypertension

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2258004

Genetics of insulin resistance

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2258004

Activation of protein kinase B beta and gamma isoforms by insulin in vivo and by 3-phosphoinositide-dependent protein kinase-1 in vitro: comparison with protein kinase B alpha

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2258004

Mutations in the kinase Rsk-2 associated with Coffin-Lowry syndrome

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2258004

Expression of a constitutively active Akt Ser/Thr kinase in 3T3-L1 adipocytes stimulates glucose uptake and glucose transporter 4 translocation

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2258004

Active and inactive protein kinases: structural basis for regulation

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2258004

Molecular mechanisms of inherited insulin resistance.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2258004

Molecular Modeling of the Jak3 Kinase Domains and Structural Basis for Severe Combined Immunodeficiency

28 June 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/15166380

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

The genetics of type 2 diabetes

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/15166380

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1126/SCIENCE.1096706

1 reference

14 August 2017

1 reference

14 August 2017

PubMed publication ID

15166380

1 reference