FOXP3+ regulatory T cells in the human immune system (Q29307487)

9 April 2017

David A. Hafler

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9 April 2017

Shimon Sakaguchi

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9 April 2017

Makoto Miyara

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9 April 2017

Cristina M. Costantino

series ordinal

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9 April 2017

publication date

18 June 2010

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Nature Reviews Immunology

9 April 2017

published in

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9 April 2017

volume

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9 April 2017

issue

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9 April 2017

page(s)

490-500

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Regulatory T cells and immune tolerance

9 April 2017

cites work

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Human regulatory T cells and their role in autoimmune disease

31 March 2020

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Regulatory T cells - a brief history and perspective

31 March 2020

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Human regulatory T cells and autoimmunity

31 March 2020

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Functional delineation and differentiation dynamics of human CD4+ T cells expressing the FoxP3 transcription factor

31 March 2020

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Regulation of immune responses by T cells

31 March 2020

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CD4+CD25high regulatory cells in human peripheral blood

31 March 2020

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Antigen-specific T cell suppression by human CD4+CD25+ regulatory T cells.

31 March 2020

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Human cd25(+)cd4(+) t regulatory cells suppress naive and memory T cell proliferation and can be expanded in vitro without loss of function.

31 March 2020

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Human CD4(+)CD25(+) cells: a naturally occurring population of regulatory T cells.

31 March 2020

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Identification and functional characterization of human CD4(+)CD25(+) T cells with regulatory properties isolated from peripheral blood

31 March 2020

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Ex vivo isolation and characterization of CD4(+)CD25(+) T cells with regulatory properties from human blood

31 March 2020

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An essential role for Scurfin in CD4+CD25+ T regulatory cells

31 March 2020

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Foxp3 programs the development and function of CD4+CD25+ regulatory T cells

31 March 2020

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Control of regulatory T cell development by the transcription factor Foxp3

31 March 2020

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Analysis of FOXP3 protein expression in human CD4+CD25+ regulatory T cells at the single-cell level

31 March 2020

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Single-cell analysis of normal and FOXP3-mutant human T cells: FOXP3 expression without regulatory T cell development

31 March 2020

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MHC class II expression identifies functionally distinct human regulatory T cells

31 March 2020

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Two functional subsets of FOXP3+ regulatory T cells in human thymus and periphery

31 March 2020

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Developmental regulation of Foxp3 expression during ontogeny.

31 March 2020

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Selective depletion of Foxp3+ regulatory T cells induces a scurfy-like disease

31 March 2020

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Thymopoiesis, regulatory T cells, and TCRVbeta expression in thymoma with and without myasthenia gravis, and modulatory effects of steroid therapy

31 March 2020

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Cutting edge: human CD4-CD8- thymocytes express FOXP3 in the absence of a TCR

31 March 2020

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The FOXP3+ subset of human CD4+CD8+ thymocytes is immature and subject to intrathymic selection

31 March 2020

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Rare development of Foxp3+ thymocytes in the CD4+CD8+ subset

31 March 2020

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Differentiation of regulatory Foxp3+ T cells in the thymic cortex

31 March 2020

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Role of TCR specificity in CD4+ CD25+ regulatory T-cell selection

31 March 2020

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IL-2 family of cytokines in T regulatory cell development and homeostasis

31 March 2020

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Development of alphabeta T cells in the human thymus

31 March 2020

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Human thymic stromal lymphopoietin promotes dendritic cell-mediated CD4+ T cell homeostatic expansion.

31 March 2020

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Thymic stromal lymphopoietin-activated plasmacytoid dendritic cells induce the generation of FOXP3+ regulatory T cells in human thymus

31 March 2020

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Hassall's corpuscles instruct dendritic cells to induce CD4+CD25+ regulatory T cells in human thymus

31 March 2020

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TSLP: an epithelial cell cytokine that regulates T cell differentiation by conditioning dendritic cell maturation

31 March 2020

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Ontogeny of CD4+CD25+ regulatory/suppressor T cells in human fetuses

31 March 2020

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Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse

31 March 2020

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X-linked neonatal diabetes mellitus, enteropathy and endocrinopathy syndrome is the human equivalent of mouse scurfy

31 March 2020

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The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3

31 March 2020

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Crucial role of FOXP3 in the development and function of human CD25+CD4+ regulatory T cells

31 March 2020

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Functional analysis of FOXP3.

31 March 2020

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The role of 2 FOXP3 isoforms in the generation of human CD4+ Tregs.

31 March 2020

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Forced overexpression of either of the two common human Foxp3 isoforms can induce regulatory T cells from CD4(+)CD25(-) cells

31 March 2020

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Isoform-specific inhibition of ROR alpha-mediated transcriptional activation by human FOXP3

31 March 2020

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Foxp3 interacts with nuclear factor of activated T cells and NF-kappa B to repress cytokine gene expression and effector functions of T helper cells

31 March 2020

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Analysis of FOXP3 reveals multiple domains required for its function as a transcriptional repressor

31 March 2020

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Induction of FoxP3 and acquisition of T regulatory activity by stimulated human CD4+CD25– T cells

31 March 2020

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De novo generation of antigen-specific CD4+CD25+ regulatory T cells from human CD4+CD25- cells

31 March 2020

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Generation of potent and stable human CD4+ T regulatory cells by activation-independent expression of FOXP3.

31 March 2020

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Loss of FOXP3 expression in natural human CD4+CD25+ regulatory T cells upon repetitive in vitro stimulation.

31 March 2020

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Inducible reprogramming of human T cells into Treg cells by a conditionally active form of FOXP3

31 March 2020

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A functionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF-beta and retinoic acid-dependent mechanism

31 March 2020

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Foxp3 Transcription-Factor-Dependent and -Independent Regulation of the Regulatory T Cell Transcriptional Signature

31 March 2020

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Foxp3+ regulatory T cells: differentiation, specification, subphenotypes

31 March 2020

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Induction of FOXP3 expression in naive human CD4+FOXP3 T cells by T-cell receptor stimulation is transforming growth factor-beta dependent but does not confer a regulatory phenotype

31 March 2020

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Activation-induced FOXP3 in human T effector cells does not suppress proliferation or cytokine production

31 March 2020

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CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells

31 March 2020

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Expression of interleukin (IL)-2 and IL-7 receptors discriminates between human regulatory and activated T cells

31 March 2020

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Interleukin-7 receptor expression: intelligent design

31 March 2020

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Activated T cells complicate the identification of regulatory T cells in rheumatoid arthritis.

31 March 2020

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Activation induces rapid and profound alterations in the trafficking of T cells.

31 March 2020

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Persistence of naive CD45RA+ regulatory T cells in adult life.

31 March 2020

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A peripheral circulating compartment of natural naive CD4 Tregs

31 March 2020

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Naive regulatory T cells: a novel subpopulation defined by resistance toward CD95L-mediated cell death.

31 March 2020

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Continuous activation of autoreactive CD4+ CD25+ regulatory T cells in the steady state.

31 March 2020

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Lymphokine regulation of CD45R expression on human T cell clones

31 March 2020

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In contrast to effector T cells, CD4+CD25+FoxP3+ regulatory T cells are highly susceptible to CD95 ligand- but not to TCR-mediated cell death.

31 March 2020

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Cutting Edge: Responder T cells regulate human DR+ effector regulatory T cell activity via granzyme B

31 March 2020

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Human CD4+ CD25hi Foxp3+ regulatory T cells are derived by rapid turnover of memory populations in vivo

31 March 2020

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Expansion of human regulatory T-cells from patients with type 1 diabetes

31 March 2020

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CD4+CD25+ immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production

31 March 2020

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How regulatory T cells work

31 March 2020

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Mechanisms of foxp3+ T regulatory cell-mediated suppression

31 March 2020

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CTLA-4 control over Foxp3+ regulatory T cell function

31 March 2020

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Inhibition of human CD4(+)CD25(+high) regulatory T cell function

31 March 2020

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IL-17-producing human peripheral regulatory T cells retain suppressive function

31 March 2020

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Human memory FOXP3+ Tregs secrete IL-17 ex vivo and constitutively express the T(H)17 lineage-specific transcription factor RORgamma t.

31 March 2020

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Role of regulatory T cells and FOXP3 in human diseases.

31 March 2020

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Therapeutic approaches to allergy and autoimmunity based on FoxP3+ regulatory T-cell activation and expansion

31 March 2020

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First-in-man clinical results of the treatment of patients with graft versus host disease with human ex vivo expanded CD4+CD25+CD127- T regulatory cells

31 March 2020

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Large-scale in vitro expansion of polyclonal human CD4(+)CD25high regulatory T cells.

31 March 2020

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Only the CD45RA+ subpopulation of CD4+CD25high T cells gives rise to homogeneous regulatory T-cell lines upon in vitro expansion.

31 March 2020

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Rapamycin promotes expansion of functional CD4+CD25+FOXP3+ regulatory T cells of both healthy subjects and type 1 diabetic patients

31 March 2020

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Regulatory T-cell functions are subverted and converted owing to attenuated Foxp3 expression

31 March 2020

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Instability of the transcription factor Foxp3 leads to the generation of pathogenic memory T cells in vivo

31 March 2020

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Deacetylase inhibition promotes the generation and function of regulatory T cells.

31 March 2020

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FDA approval summary: vorinostat for treatment of advanced primary cutaneous T-cell lymphoma

31 March 2020

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Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival

31 March 2020

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Regulatory-T-cell inhibition versus depletion: the right choice in cancer immunotherapy

31 March 2020

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Immunologic and clinical effects of antibody blockade of cytotoxic T lymphocyte-associated antigen 4 in previously vaccinated cancer patients

31 March 2020

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CD4+CD25+ regulatory T cells control Leishmania major persistence and immunity

31 March 2020

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Coordination of early protective immunity to viral infection by regulatory T cells

31 March 2020

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T cells with a CD4+CD25+ regulatory phenotype suppress in vitro proliferation of virus-specific CD8+ T cells during chronic hepatitis C virus infection.

31 March 2020

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Human immunodeficiency virus-driven expansion of CD4+CD25+ regulatory T cells, which suppress HIV-specific CD4 T-cell responses in HIV-infected patients

31 March 2020

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Increased percentage of CD4+CD25+ regulatory T cells during septic shock is due to the decrease of CD4+CD25- lymphocytes.

31 March 2020

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Regulatory T cells: how do they suppress immune responses?

31 March 2020

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Maternal alloantigens promote the development of tolerogenic fetal regulatory T cells in utero

31 March 2020

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CD25+CD4+ T cells in human cord blood: an immunoregulatory subset with naive phenotype and specific expression of forkhead box p3 (Foxp3) gene.

31 March 2020

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Engagement of B7 on effector T cells by regulatory T cells prevents autoimmune disease

31 March 2020

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Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression

31 March 2020

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Role of LAG-3 in regulatory T cells.

31 March 2020

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Cutting edge: contact-mediated suppression by CD4+CD25+ regulatory cells involves a granzyme B-dependent, perforin-independent mechanism

31 March 2020

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Granzyme B and perforin are important for regulatory T cell-mediated suppression of tumor clearance

31 March 2020

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Differential expression of granzymes A and B in human cytotoxic lymphocyte subsets and T regulatory cells

31 March 2020

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Human circulating CD4+CD25highFoxp3+ regulatory T cells kill autologous CD8+ but not CD4+ responder cells by Fas-mediated apoptosis

31 March 2020

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Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3

31 March 2020

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CD4+ FoxP3+ regulatory T cells confer infectious tolerance in a TGF-beta-dependent manner

31 March 2020

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Regulatory T cells and infection: a dangerous necessity

31 March 2020

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Interleukin-10-secreting type 1 regulatory T cells in rodents and humans.

31 March 2020

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Galectin-1: a key effector of regulation mediated by CD4+CD25+ T cells

31 March 2020

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CD4+CD25+Foxp3+ regulatory T cells induce cytokine deprivation-mediated apoptosis of effector CD4+ T cells

31 March 2020

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The inhibitory cytokine IL-35 contributes to regulatory T-cell function

31 March 2020

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Human CD4+ CD25+ Foxp3+ regulatory T cells do not constitutively express IL-35.

31 March 2020

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Organ-specific autoimmune diseases induced in mice by elimination of T cell subset. I. Evidence for the active participation of T cells in natural self-tolerance; deficit of a T cell subset as a possible cause of autoimmune disease

31 March 2020

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OX-22high CD4+ T cells induce wasting disease with multiple organ pathology: prevention by the OX-22low subset

31 March 2020

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Immunologic self-tolerance maintained by CD25+CD4+ naturally anergic and suppressive T cells: induction of autoimmune disease by breaking their anergic/suppressive state

31 March 2020

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Thymus and Reproduction: Sex-Linked Dysgenesia of the Gonad after Neonatal Thymectomy in Mice

31 March 2020

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Autoreactive T cells in healthy individuals

31 March 2020

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CD4+CD25+ regulatory T cells suppress tumor immunity but are sensitive to cyclophosphamide which allows immunotherapy of established tumors to be curative

31 March 2020

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Cell interactions in the induction of tolerance: the role of thymic lymphocytes

31 March 2020

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12 December 2020

Thymus and autoimmunity: production of CD25+CD4+ naturally anergic and suppressive T cells as a key function of the thymus in maintaining immunologic self-tolerance

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12 December 2020

Ontogeny of human T cells

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12 December 2020

Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases

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12 December 2020