Essential biphasic role for JAK3 catalytic activity in IL-2 receptor signaling (Q28834529)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27018889%20AND%20SRC:MED&resulttype=core&format=json

31 March 2020

title

Essential biphasic role for JAK3 catalytic activity in IL-2 receptor signaling (English)

1 reference

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31 March 2020

0 references

Kenji Uchida

1 reference

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31 March 2020

Jack Taunton

series ordinal

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31 March 2020

language of work or name

English

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publication date

28 March 2016

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31 March 2020

published in

Nature Chemical Biology

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31 March 2020

volume

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31 March 2020

issue

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31 March 2020

page(s)

373-379

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Covalent docking of large libraries for the discovery of chemical probes

31 March 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4837022

Janus kinases in immune cell signaling

16 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4837022

Requirement for Tec kinases Rlk and Itk in T cell receptor signaling and immunity

16 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4837022

Functional activation of Jak1 and Jak3 by selective association with IL-2 receptor subunits

16 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4837022

Interleukin-2 signaling via STAT5 constrains T helper 17 cell generation

16 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4837022

Development of Selective Covalent Janus Kinase 3 Inhibitors.

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4837022

Tricyclic covalent inhibitors selectively target Jak3 through an active site thiol.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4837022

Alopecia areata is driven by cytotoxic T lymphocytes and is reversed by JAK inhibition.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4837022

A road map to evaluate the proteome-wide selectivity of covalent kinase inhibitors

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4837022

Opposing actions of IL-2 and IL-21 on Th9 differentiation correlate with their differential regulation of BCL6 expression

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4837022

Discovery and development of Janus kinase (JAK) inhibitors for inflammatory diseases

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4837022

Qualitatively different T cell phenotypic responses to IL-2 versus IL-15 are unified by identical dependences on receptor signal strength and duration

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4837022

The signaling suppressor CIS controls proallergic T cell development and allergic airway inflammation.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4837022

Interleukin-2 at the crossroads of effector responses, tolerance, and immunotherapy

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4837022

Critical Role of STAT5 transcription factor tetramerization for cytokine responses and normal immune function

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4837022

Suppression of cytokine signaling by SOCS3: characterization of the mode of inhibition and the basis of its specificity

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4837022

Jak1 Has a Dominant Role over Jak3 in Signal Transduction through γc-Containing Cytokine Receptors

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4837022

Modulation of innate and adaptive immune responses by tofacitinib (CP-690,550).

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4837022

Sustained signaling by canonical helper T cell cytokines throughout the reactive lymph node.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4837022

New insights into the regulation of T cells by gamma(c) family cytokines

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4837022

Tec kinases regulate T-lymphocyte development and function: new insights into the roles of Itk and Rlk/Txk

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4837022

STAT5 is essential for Akt/p70S6 kinase activity during IL-2-induced lymphocyte proliferation

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4837022

The role of cyclin-dependent kinases in T-cell development, proliferation, and function

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4837022

Fluorescent cell barcoding in flow cytometry allows high-throughput drug screening and signaling profiling

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4837022

Stat5a/b are essential for normal lymphoid development and differentiation

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4837022

Differential substrate recognition capabilities of Janus family protein tyrosine kinases within the interleukin 2 receptor (IL2R) system: Jak3 as a potential molecular target for treatment of leukemias with a hyperactive Jak-Stat signaling machinery

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4837022

Peripheral expression of Jak3 is required to maintain T lymphocyte function

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4837022

The interleukin-2 T-cell system: a new cell growth model.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4837022

The comparative roles of suppressor of cytokine signaling-1 and -3 in the inhibition and desensitization of cytokine signaling

20 June 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2056

Preclinical to clinical translation of tofacitinib, a Janus kinase inhibitor, in rheumatoid arthritis

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2056

Defects in B lymphocyte maturation and T lymphocyte activation in mice lacking Jak3

21 January 2018

1 reference

12 December 2020

Phosphatidylinositol 3-Kinase Couples the Interleukin-2 Receptor to the Cell Cycle Regulator E2F

1 reference

12 December 2020

Differential regulation of T-cell growth by IL-2 and IL-15

1 reference

12 December 2020

IL-7-induced proliferation of recent thymic emigrants requires activation of the PI3K pathway

1 reference

12 December 2020

Suppressor of Cytokine Signaling-1 Regulates Signaling in Response to Interleukin-2 and Other γc-dependent Cytokines in Peripheral T Cells

1 reference

12 December 2020

Identifiers

DOI

10.1038/NCHEMBIO.2056

2 references

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31 March 2020

1 reference

2 references

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31 March 2020

PubMed publication ID

27018889

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27018889%20AND%20SRC:MED&resulttype=core&format=json