Differential substrate recognition capabilities of Janus family protein tyrosine kinases within the interleukin 2 receptor (IL2R) system: Jak3 as a potential molecular target for treatment of leukemias with a hyperactive Jak-Stat signaling machinery (Q40971179)

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scientific article published on January 1999

Language	Label	Description	Also known as
English	Differential substrate recognition capabilities of Janus family protein tyrosine kinases within the interleukin 2 receptor (IL2R) system: Jak3 as a potential molecular target for treatment of leukemias with a hyperactive Jak-Stat signaling machinery	scientific article published on January 1999

Statements

scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

25 September 2017

Differential substrate recognition capabilities of Janus family protein tyrosine kinases within the interleukin 2 receptor (IL2R) system: Jak3 as a potential molecular target for treatment of leukemias with a hyperactive Jak-Stat signaling machinery (English)

1 reference

Europe PubMed Central

PubMed publication ID

25 September 2017

author name string

Witthuhn BA

1

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Europe PubMed Central

PubMed publication ID

25 September 2017

Williams MD

2

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Europe PubMed Central

PubMed publication ID

25 September 2017

Kerawalla H

3

1 reference

Europe PubMed Central

PubMed publication ID

25 September 2017

Uckun FM

4

1 reference

Europe PubMed Central

PubMed publication ID

25 September 2017

publication date

1 January 1999

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Europe PubMed Central

PubMed publication ID

25 September 2017

Leukemia & Lymphoma

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Europe PubMed Central

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25 September 2017

32

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PubMed publication ID

25 September 2017

3-4

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Europe PubMed Central

PubMed publication ID

25 September 2017

289-297

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PubMed publication ID

25 September 2017

Jaks and Stats in signaling by the cytokine receptor superfamily

1 reference

https://api.crossref.org/works/10.3109%2F10428199909167389

21 January 2018

Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins

1 reference

https://api.crossref.org/works/10.3109%2F10428199909167389

21 January 2018

Receptors for interleukin (IL)-4 do not associate with the common gamma chain, and IL-4 induces the phosphorylation of JAK2 tyrosine kinase in human colon carcinoma cells

1 reference

https://api.crossref.org/works/10.3109%2F10428199909167389

21 January 2018

Stat recruitment by tyrosine-phosphorylated cytokine receptors: an ordered reversible affinity-driven process

1 reference

https://api.crossref.org/works/10.3109%2F10428199909167389

21 January 2018

Choice of STATs and other substrates specified by modular tyrosine-based motifs in cytokine receptors

1 reference

https://api.crossref.org/works/10.3109%2F10428199909167389

21 January 2018

An interleukin-4-induced transcription factor: IL-4 Stat

1 reference

https://api.crossref.org/works/10.3109%2F10428199909167389

21 January 2018

Different interleukin 2 receptor beta-chain tyrosines couple to at least two signaling pathways and synergistically mediate interleukin 2-induced proliferation

1 reference

https://api.crossref.org/works/10.3109%2F10428199909167389

21 January 2018

Activation of Stat5 by interleukin 2 requires a carboxyl-terminal region of the interleukin 2 receptor beta chain but is not essential for the proliferative signal transmission

1 reference

https://api.crossref.org/works/10.3109%2F10428199909167389

21 January 2018

Erythropoietin induces activation of Stat5 through association with specific tyrosines on the receptor that are not required for a mitogenic response.

1 reference

https://api.crossref.org/works/10.3109%2F10428199909167389

21 January 2018

A single STAT recruitment module in a chimeric cytokine receptor complex is sufficient for STAT activation

1 reference

https://api.crossref.org/works/10.3109%2F10428199909167389

21 January 2018

Roles of JAKs in activation of STATs and stimulation of c-fos gene expression by epidermal growth factor

1 reference

https://api.crossref.org/works/10.3109%2F10428199909167389

21 January 2018

Requirement for an initial signal from the membrane-proximal region of the interleukin 2 receptor gamma(c) chain for Janus kinase activation leading to T cell proliferation

1 reference

https://api.crossref.org/works/10.3109%2F10428199909167389

21 January 2018

The amino terminus of JAK3 is necessary and sufficient for binding to the common gamma chain and confers the ability to transmit interleukin 2-mediated signals

1 reference

https://api.crossref.org/works/10.3109%2F10428199909167389

21 January 2018

Phosphorylation and Activation of the DNA Binding Activity of Purified Stat1 by the Janus Protein-tyrosine Kinases and the Epidermal Growth Factor Receptor

1 reference

https://api.crossref.org/works/10.3109%2F10428199909167389

21 January 2018

In vitro activation of Stat3 by epidermal growth factor receptor kinase

1 reference

https://api.crossref.org/works/10.3109%2F10428199909167389

21 January 2018

An alternative pathway for STAT activation that is mediated by the direct interaction between JAK and STAT.

1 reference

https://api.crossref.org/works/10.3109%2F10428199909167389

21 January 2018

STAM, signal transducing adaptor molecule, is associated with Janus kinases and involved in signaling for cell growth and c-myc induction

1 reference

https://api.crossref.org/works/10.3109%2F10428199909167389

21 January 2018

A new protein containing an SH2 domain that inhibits JAK kinases

1 reference

https://api.crossref.org/works/10.3109%2F10428199909167389

21 January 2018

Involvement of the Jak-3 Janus kinase in signalling by interleukins 2 and 4 in lymphoid and myeloid cells

1 reference

https://api.crossref.org/works/10.3109%2F10428199909167389

21 January 2018

Activation of Jak2 catalytic activity requires phosphorylation of Y1007 in the kinase activation loop

1 reference

https://api.crossref.org/works/10.3109%2F10428199909167389

21 January 2018

Crystal structure of the tyrosine kinase domain of the human insulin receptor

1 reference

https://api.crossref.org/works/10.3109%2F10428199909167389

21 January 2018

Interaction between the Components of the Interferon γ Receptor Complex

1 reference

https://api.crossref.org/works/10.3109%2F10428199909167389

21 January 2018

Identification of an interferon-gamma receptor alpha chain sequence required for JAK-1 binding

1 reference

https://api.crossref.org/works/10.3109%2F10428199909167389

21 January 2018

The T cell receptor/CD3 complex: a dynamic protein ensemble

1 reference

https://api.crossref.org/works/10.3109%2F10428199909167389

21 January 2018

Cytokine signaling through nonreceptor protein tyrosine kinases

1 reference

https://api.crossref.org/works/10.3109%2F10428199909167389

21 January 2018

Interleukin 2 (IL-2)-induced tyrosine phosphorylation of IL-2 receptor p75

1 reference

https://api.crossref.org/works/10.3109%2F10428199909167389

21 January 2018

IL-2-dependent in vivo and in vitro tyrosine phosphorylation of IL-2 receptor gamma chain

1 reference

https://api.crossref.org/works/10.3109%2F10428199909167389

21 January 2018

The IL-2/IL-2 receptor system: a current overview

1 reference

https://api.crossref.org/works/10.3109%2F10428199909167389

21 January 2018

Analysis of interleukin-2-dependent signal transduction through the Shc/Grb2 adapter pathway. Interleukin-2-dependent mitogenesis does not require Shc phosphorylation or receptor association

1 reference

https://api.crossref.org/works/10.3109%2F10428199909167389

21 January 2018

Distinct tyrosine residues within the interleukin-2 receptor beta chain drive signal transduction specificity, redundancy, and diversity

1 reference

https://api.crossref.org/works/10.3109%2F10428199909167389

21 January 2018

Interaction of IL-2R beta and gamma c chains with Jak1 and Jak3: implications for XSCID and XCID

1 reference

https://api.crossref.org/works/10.3109%2F10428199909167389

21 January 2018

Functional activation of Jak1 and Jak3 by selective association with IL-2 receptor subunits

1 reference

https://api.crossref.org/works/10.3109%2F10428199909167389

21 January 2018

Phosphorylation and activation of the Jak-3 Janus kinase in response to interleukin-2.

1 reference

https://api.crossref.org/works/10.3109%2F10428199909167389

21 January 2018

Homodimerization of the human interleukin 4 receptor alpha chain induces Cepsilon germline transcripts in B cells in the absence of the interleukin 2 receptor gamma chain

1 reference

https://api.crossref.org/works/10.3109%2F10428199909167389

21 January 2018

Jak1 expression is required for mediating interleukin-4-induced tyrosine phosphorylation of insulin receptor substrate and Stat6 signaling molecules

1 reference

https://api.crossref.org/works/10.3109%2F10428199909167389

21 January 2018

Janus kinase-dependent activation of insulin receptor substrate 1 in response to interleukin-4, oncostatin M, and the interferons

1 reference

https://api.crossref.org/works/10.3109%2F10428199909167389

21 January 2018

Critical role of the interleukin 2 (IL-2) receptor gamma-chain-associated Jak3 in the IL-2-induced c-fos and c-myc, but not bcl-2, gene induction

1 reference

https://api.crossref.org/works/10.3109%2F10428199909167389

21 January 2018

Mutation in the Jak kinase JH2 domain hyperactivates Drosophila and mammalian Jak-Stat pathways

1 reference

https://api.crossref.org/works/10.3109%2F10428199909167389

21 January 2018

Complete structure and expression in transfected cells of high affinity IgE receptor

1 reference

https://api.crossref.org/works/10.3109%2F10428199909167389

21 January 2018

Identifiers

10.3109/10428199909167389

1 reference

Europe PubMed Central

PubMed publication ID

25 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

25 September 2017

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