Insulin-stimulated disassociation of the SOS-Grb2 complex (Q28615780)

3 February 2017

title

Insulin-stimulated disassociation of the SOS-Grb2 complex (English)

1 reference

3 February 2017

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S. B. Waters

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3 February 2017

K. Yamauchi

series ordinal

1 reference

3 February 2017

J. E. Pessin

series ordinal

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3 February 2017

language of work or name

English

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publication date

1 May 1995

1 reference

Molecular and Cellular Biology

3 February 2017

published in

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3 February 2017

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3 February 2017

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3 February 2017

page(s)

2791–2799

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Complexes of Ras.GTP with Raf-1 and mitogen-activated protein kinase kinase

3 February 2017

cites work

1 reference

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Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2

17 March 2017

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The SH2/SH3 domain-containing protein GRB2 interacts with tyrosine-phosphorylated IRS1 and Shc: implications for insulin control of ras signalling

17 March 2017

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Guanine-nucleotide-releasing factor hSos1 binds to Grb2 and links receptor tyrosine kinases to Ras signalling

17 March 2017

1 reference

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The SH2 and SH3 domains of mammalian Grb2 couple the EGF receptor to the Ras activator mSos1

17 March 2017

1 reference

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Normal and oncogenic p21ras proteins bind to the amino-terminal regulatory domain of c-Raf-1

17 March 2017

1 reference

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The function of GRB2 in linking the insulin receptor to Ras signaling pathways

17 March 2017

1 reference

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Binding of 14-3-3 proteins to the protein kinase Raf and effects on its activation

17 March 2017

1 reference

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Activation of Raf-1 by 14-3-3 proteins

17 March 2017

1 reference

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SH2 domains recognize specific phosphopeptide sequences

17 March 2017

1 reference

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Pleiotropic insulin signals are engaged by multisite phosphorylation of IRS-1

17 March 2017

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A cytoplasmic protein stimulates normal N-ras p21 GTPase, but does not affect oncogenic mutants

17 March 2017

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Modulation of guanine nucleotides bound to Ras in NIH3T3 cells by oncogenes, growth factors, and the GTPase activating protein (GAP)

17 March 2017

1 reference

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Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230510

A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction

17 March 2017

1 reference

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Identification of a mammalian gene structurally and functionally related to the CDC25 gene of Saccharomyces cerevisiae

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230510

Molecular cloning of cDNAs encoding a guanine-nucleotide-releasing factor for Ras p21

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230510

Phosphorylation of the S. cerevisiae Cdc25 in response to glucose results in its dissociation from Ras

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230510

The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230510

Association of Sos Ras exchange protein with Grb2 is implicated in tyrosine kinase signal transduction and transformation

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230510

The GTPase dynamin binds to and is activated by a subset of SH3 domains

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230510

The mitogen-activated protein kinase signal transduction pathway

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230510

Association of the Shc and Grb2/Sem5 SH2-containing proteins is implicated in activation of the Ras pathway by tyrosine kinases

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230510

The insulin-elicited 160 kDa phosphotyrosine protein in mouse adipocytes is an insulin receptor substrate 1: identification by cloning

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230510

Signal transduction via the MAP kinases: proceed at your own RSK.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230510

Binding of the Ras activator son of sevenless to insulin receptor substrate-1 signaling complexes

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230510

Phosphorylation of Xenopus mitogen-activated protein (MAP) kinase kinase by MAP kinase kinase kinase and MAP kinase.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230510

GTP-dependent association of Raf-1 with Ha-Ras: identification of Raf as a target downstream of Ras in mammalian cells.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230510

Insulin activates p21Ras and guanine nucleotide releasing factor in cells expressing wild type and mutant insulin receptors.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230510

The role of p21ras in receptor tyrosine kinase signaling

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230510

Nck associates with the SH2 domain-docking protein IRS-1 in insulin-stimulated cells

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230510

Involvement of Shc in insulin- and epidermal growth factor-induced activation of p21ras

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230510

Phosphorylation of the Ras nucleotide exchange factor son of sevenless by mitogen-activated protein kinase.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230510

Membrane-targeting potentiates guanine nucleotide exchange factor CDC25 and SOS1 activation of Ras transforming activity

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230510

The IRS-1 signaling system

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230510

Raf meets Ras: completing the framework of a signal transduction pathway

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230510

Enhancement or inhibition of insulin signaling by insulin receptor substrate 1 is cell context dependent

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230510

Membrane targeting of the nucleotide exchange factor Sos is sufficient for activating the Ras signaling pathway.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230510

Signal transduction pathways from insulin receptors to Ras. Analysis by mutant insulin receptors.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230510

Microtubules and Src homology 3 domains stimulate the dynamin GTPase via its C-terminal domain

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230510

Ras1 and a putative guanine nucleotide exchange factor perform crucial steps in signaling by the sevenless protein tyrosine kinase.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230510

Purification and properties of extracellular signal-regulated kinase 1, an insulin-stimulated microtubule-associated protein 2 kinase

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230510

Evidence that extracellular signal-regulated kinases are the insulin-activated Raf-1 kinase kinases

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230510

Raf-1 is a potential substrate for mitogen-activated protein kinase in vivo

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230510

Identification of murine homologues of the Drosophila son of sevenless gene: potential activators of ras

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230510

Differentiation factors, including nerve growth factor, fibroblast growth factor, and interleukin-6, induce an accumulation of an active Ras.GTP complex in rat pheochromocytoma PC12 cells

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230510

Cloning by functional complementation of a mouse cDNA encoding a homologue of CDC25, a Saccharomyces cerevisiae RAS activator

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230510

Insulin-induced phosphorylation of the 46- and 52-kDa Shc proteins.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230510

Evidence supporting a passive role for the insulin receptor transmembrane domain in insulin-dependent signal transduction

27 November 2018

1 reference

12 December 2020

Different interactions of Grb2/Ash molecule with the NGF and EGF receptors in rat pheochromocytoma PC12 cells

1 reference

12 December 2020

Stimulatory effects of yeast and mammalian 14-3-3 proteins on the Raf protein kinase

1 reference

12 December 2020

Disassembly of Son-of-sevenless proteins from Grb2 during p21ras desensitization by insulin

1 reference

12 December 2020

Insulin receptor synthesis and turnover in differentiating 3T3-L1 preadipocytes

1 reference

12 December 2020

Insulin signalling: the role of insulin receptor substrate 1

1 reference

12 December 2020

Insulin rapidly stimulates tyrosine phosphorylation of a Mr-185,000 protein in intact cells

1 reference

12 December 2020

Feedback regulation of mitogen-activated protein kinase kinase kinase activity of c-Raf-1 by insulin and phorbol ester stimulation

1 reference

12 December 2020

Identifiers

DOI

10.1128/MCB.15.5.2791

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PMC publication ID

230510

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1 reference