The regulation of autophagosome dynamics by huntingtin and HAP1 is disrupted by expression of mutant huntingtin, leading to defective cargo degradation (Q28591685)

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English	The regulation of autophagosome dynamics by huntingtin and HAP1 is disrupted by expression of mutant huntingtin, leading to defective cargo degradation	scientific article

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scholarly article

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Europe PubMed Central

PubMed publication ID

21 June 2017

The regulation of autophagosome dynamics by huntingtin and HAP1 is disrupted by expression of mutant huntingtin, leading to defective cargo degradation (English)

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Europe PubMed Central

PubMed publication ID

21 June 2017

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Huntingtin-associated protein 1

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GOA release 2020-03-11

author name string

Yvette C Wong

1

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Europe PubMed Central

PubMed publication ID

21 June 2017

Erika L F Holzbaur

2

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Europe PubMed Central

PubMed publication ID

21 June 2017

language of work or name

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publication date

1 January 2014

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Europe PubMed Central

PubMed publication ID

21 June 2017

Journal of Neuroscience

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Europe PubMed Central

PubMed publication ID

21 June 2017

34

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Europe PubMed Central

PubMed publication ID

21 June 2017

4

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Europe PubMed Central

PubMed publication ID

21 June 2017

1293-1305

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Europe PubMed Central

PubMed publication ID

21 June 2017

describes a project that uses

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Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3898289/fullTextXML

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dnc-1/dynactin 1 knockdown disrupts transport of autophagosomes and induces motor neuron degeneration

1 reference

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17 March 2017

Guidelines for the use and interpretation of assays for monitoring autophagy

1 reference

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17 March 2017

Huntingtin associated protein 1 regulates trafficking of the amyloid precursor protein and modulates amyloid beta levels in neurons

1 reference

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17 March 2017

Shaping the role of mitochondria in the pathogenesis of Huntington's disease

1 reference

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17 March 2017

Phosphorylation of the autophagy receptor optineurin restricts Salmonella growth

1 reference

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17 March 2017

pARIS-htt: an optimised expression platform to study huntingtin reveals functional domains required for vesicular trafficking

1 reference

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17 March 2017

Delivery of GABAARs to synapses is mediated by HAP1-KIF5 and disrupted by mutant huntingtin.

1 reference

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17 March 2017

FYCO1 is a Rab7 effector that binds to LC3 and PI3P to mediate microtubule plus end-directed vesicle transport

1 reference

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17 March 2017

Rhes, a striatal specific protein, mediates mutant-huntingtin cytotoxicity

1 reference

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17 March 2017

In vitro reconstitution of fusion between immature autophagosomes and endosomes

1 reference

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17 March 2017

Huntingtin phosphorylation acts as a molecular switch for anterograde/retrograde transport in neurons

1 reference

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17 March 2017

Huntingtin has a membrane association signal that can modulate huntingtin aggregation, nuclear entry and toxicity

1 reference

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17 March 2017

p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy

1 reference

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17 March 2017

Loss of autophagy in the central nervous system causes neurodegeneration in mice

1 reference

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17 March 2017

Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice

1 reference

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17 March 2017

Interaction of Huntingtin-associated protein-1 with kinesin light chain: implications in intracellular trafficking in neurons

1 reference

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17 March 2017

Mutant huntingtin impairs axonal trafficking in mammalian neurons in vivo and in vitro

1 reference

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17 March 2017

Huntingtin controls neurotrophic support and survival of neurons by enhancing BDNF vesicular transport along microtubules

1 reference

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17 March 2017

Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease

1 reference

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17 March 2017

In vivo analysis of autophagy in response to nutrient starvation using transgenic mice expressing a fluorescent autophagosome marker

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3898289

17 March 2017

LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3898289

17 March 2017

Expression of huntingtin-associated protein-1 in neuronal cells implicates a role in neuritic growth

1 reference

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17 March 2017

Interaction of huntingtin-associated protein with dynactin P150Glued

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3898289

17 March 2017

Huntingtin-associated protein 1 (HAP1) interacts with the p150Glued subunit of dynactin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3898289

17 March 2017

A huntingtin-associated protein enriched in brain with implications for pathology

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3898289

17 March 2017

Autophagosome formation: core machinery and adaptations

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3898289

7 April 2017

Autophagy gone awry in neurodegenerative diseases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3898289

7 April 2017

Dissection of the autophagosome maturation process by a novel reporter protein, tandem fluorescent-tagged LC3

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3898289

7 April 2017

Termination of autophagy and reformation of lysosomes regulated by mTOR

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3898289

7 April 2017

Aggregate-prone proteins with polyglutamine and polyalanine expansions are degraded by autophagy

1 reference

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Establishing a novel knock-in mouse line for studying neuronal cytoplasmic dynein under normal and pathologic conditions

1 reference

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29 September 2017

Autophagy receptors link myosin VI to autophagosomes to mediate Tom1-dependent autophagosome maturation and fusion with the lysosome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3898289

29 September 2017

Autophagosomes initiate distally and mature during transport toward the cell soma in primary neurons

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3898289

29 September 2017

Lysosomal Proteolysis Inhibition Selectively Disrupts Axonal Transport of Degradative Organelles and Causes an Alzheimer's-Like Axonal Dystrophy

1 reference

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29 September 2017

Mutant huntingtin binds the mitochondrial fission GTPase dynamin-related protein-1 and increases its enzymatic activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3898289

29 September 2017

Huntingtin coordinates the dynein-mediated dynamic positioning of endosomes and lysosomes

1 reference

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29 September 2017

Mouse cytoplasmic dynein intermediate chains: identification of new isoforms, alternative splicing and tissue distribution of transcripts

1 reference

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29 September 2017

Cargo recognition failure is responsible for inefficient autophagy in Huntington's disease

1 reference

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29 September 2017

A switch in retrograde signaling from survival to stress in rapid-onset neurodegeneration

1 reference

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29 September 2017

Pathogenic huntingtin inhibits fast axonal transport by activating JNK3 and phosphorylating kinesin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3898289

29 September 2017

Phosphorylation of mutant huntingtin at S421 restores anterograde and retrograde transport in neurons.

1 reference

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29 September 2017

New insights into the mechanisms of macroautophagy in mammalian cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3898289

29 September 2017

Dynein-dependent movement of autophagosomes mediates efficient encounters with lysosomes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3898289

29 September 2017

N-terminal mutant huntingtin associates with mitochondria and impairs mitochondrial trafficking

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3898289

29 September 2017

The itinerary of autophagosomes: from peripheral formation to kiss-and-run fusion with lysosomes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3898289

29 September 2017

Huntingtin facilitates dynein/dynactin-mediated vesicle transport.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3898289

29 September 2017

Small molecules enhance autophagy and reduce toxicity in Huntington's disease models.

1 reference

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29 September 2017

Intermediate chain subunit as a probe for cytoplasmic dynein function: biochemical analyses and live cell imaging in PC12 cells

1 reference

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The dynamics of autophagy visualized in live cells: from autophagosome formation to fusion with endo/lysosomes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3898289

29 September 2017

Huntington's disease: seeing the pathogenic process through a genetic lens

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3898289

29 September 2017

Dynein mutations impair autophagic clearance of aggregate-prone proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3898289

29 September 2017

Cytoplasmic aggregates trap polyglutamine-containing proteins and block axonal transport in a Drosophila model of Huntington's disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3898289

29 September 2017

Identification and developmental regulation of a neuron-specific subunit of cytoplasmic dynein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3898289

29 September 2017

Differential expression and phosphorylation of the 74-kDa intermediate chains of cytoplasmic dynein in cultured neurons and glia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3898289

29 September 2017

Purification and characterization of autophagosomes from rat hepatocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3898289

3 June 2018

In-vivo evidence for the disruption of Rab11 vesicle transport by loss of huntingtin.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3898289

27 November 2018

Enhanced sensitivity of striatal neurons to axonal transport defects induced by mutant huntingtin.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3898289

27 November 2018

Regulation of intracellular trafficking of huntingtin-associated protein-1 is critical for TrkA protein levels and neurite outgrowth.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3898289

27 November 2018

Mutant huntingtin aggregates impair mitochondrial movement and trafficking in cortical neurons

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3898289

27 November 2018

Autophagy regulates the processing of amino terminal huntingtin fragments

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3898289

27 November 2018

Neuropathogenic forms of huntingtin and androgen receptor inhibit fast axonal transport

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3898289

27 November 2018

Disruption of Axonal Transport by Loss of Huntingtin or Expression of Pathogenic PolyQ Proteins in Drosophila

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3898289

27 November 2018

Dominant phenotypes produced by the HD mutation in STHdh(Q111) striatal cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3898289

27 November 2018

Identifiers

10.1523/JNEUROSCI.1870-13.2014

1 reference

Europe PubMed Central

PubMed publication ID

21 June 2017

OpenCitations bibliographic resource ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

PMC publication ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

21 June 2017

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