Selective spider toxins reveal a role for the Nav1.1 channel in mechanical pain (Q28594552)

31 January 2017

title

Selective spider toxins reveal a role for the Nav1.1 channel in mechanical pain (English)

1 reference

Sodium channel, voltage-gated, type I, alpha

31 January 2017

main subject

1 reference

GOA release 2020-03-11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27281198%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

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8 June 2020

1 reference

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Sonia Carmen Garcia Caraballo

8 June 2020

1 reference

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8 June 2020

1 reference

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8 June 2020

1 reference

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8 June 2020

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8 June 2020

1 reference

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8 June 2020

1 reference

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8 June 2020

1 reference

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8 June 2020

1 reference

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8 June 2020

1 reference

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8 June 2020

David Julius

2 references

31 January 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27281198%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

Allan I Basbaum

1 reference

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8 June 2020

Eivind A B Undheim

1 reference

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8 June 2020

Chuchu Zhang

2 references

31 January 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27281198%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

Xidao Wang

2 references

31 January 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27281198%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

Jeremiah D Osteen

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27281198%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

Joshua J Emrick

1 reference

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8 June 2020

Cheryl L Stucky

1 reference

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8 June 2020

language of work or name

English

0 references

publication date

23 June 2016

1 reference

31 January 2017

1 reference

inferred from page(s)

2 references

31 January 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27281198%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

volume

534

2 references

31 January 2017

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8 June 2020

issue

7608

2 references

31 January 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27281198%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

page(s)

494-499

1 reference

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describes a project that uses

8 June 2020

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4919188/fullTextXML

inferred from PubMed Central ID database lookup

cites work

A distinct sodium channel voltage-sensor locus determines insect selectivity of the spider toxin Dc1a

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4919188

Nav1.1 modulation by a novel triazole compound attenuates epileptic seizures in rodents

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4919188

Inhibitory interneuron deficit links altered network activity and cognitive dysfunction in Alzheimer model

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4919188

Mapping the receptor site for α-scorpion toxins on a Na + channel voltage sensor

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4919188

ArachnoServer 2.0, an updated online resource for spider toxin sequences and structures

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4919188

The menthol receptor TRPM8 is the principal detector of environmental cold

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4919188

SCN9A mutations in paroxysmal extreme pain disorder: allelic variants underlie distinct channel defects and phenotypes

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4919188

Purification and characterization of three inhibitors of voltage-dependent K+ channels from Leiurus quinquestriatus var. hebraeus venom

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4919188

Cellular and Molecular Mechanisms of Pain

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4919188

Three Peptide Modulators of the Human Voltage-Gated Sodium Channel 1.7, an Important Analgesic Target, from the Venom of an Australian Tarantula

23 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4919188

Painful peripheral neuropathy and sodium channel mutations

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4919188

Neuroplasticity and dysfunction after gastrointestinal inflammation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4919188

Delta opioid receptors presynaptically regulate cutaneous mechanosensory neuron input to the spinal cord dorsal horn

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4919188

Gain-of-function mutations in SCN11A cause familial episodic pain

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4919188

Nonfunctional NaV1.1 familial hemiplegic migraine mutant transformed into gain of function by partial rescue of folding defects

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4919188

Linaclotide inhibits colonic nociceptors and relieves abdominal pain via guanylate cyclase-C and extracellular cyclic guanosine 3',5'-monophosphate

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4919188

Voltage sensor interaction site for selective small molecule inhibitors of voltage-gated sodium channels

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4919188

The Na(V)1.7 sodium channel: from molecule to man.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4919188

Gain-of-function Nav1.8 mutations in painful neuropathy.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4919188

Autistic-like behaviour in Scn1a+/- mice and rescue by enhanced GABA-mediated neurotransmission.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4919188

Specific deletion of NaV1.1 sodium channels in inhibitory interneurons causes seizures and premature death in a mouse model of Dravet syndrome

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4919188

Receptor-targeting mechanisms of pain-causing toxins: How ow?

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4919188

Functional properties and toxin pharmacology of a dorsal root ganglion sodium channel viewed through its voltage sensors

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4919188

Assessing the Role of the Cadherin/Catenin Complex at the Schwann Cell–Axon Interface and in the Initiation of Myelination

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4919188

Are Voltage-Gated Sodium Channels on the Dorsal Root Ganglion Involved in the Development of Neuropathic Pain?

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4919188

TRPV1-lineage neurons are required for thermal sensation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4919188

VGLUT2 expression in primary afferent neurons is essential for normal acute pain and injury-induced heat hypersensitivity.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4919188

A bivalent tarantula toxin activates the capsaicin receptor, TRPV1, by targeting the outer pore domain

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4919188

Sodium channels in normal and pathological pain

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4919188

NaV1.1 channels and epilepsy

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4919188

Ablation of TrpV1 neurons reveals their selective role in thermal pain sensation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4919188

Future potential and status of selective sodium channel blockers for the treatment of pain.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4919188

Distinct subsets of unmyelinated primary sensory fibers mediate behavioral responses to noxious thermal and mechanical stimuli

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4919188

Deconstructing voltage sensor function and pharmacology in sodium channels

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4919188

Comparative study of the distribution of the alpha-subunits of voltage-gated sodium channels in normal and axotomized rat dorsal root ganglion neurons

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4919188

Novel mutation confirms seizure locus SCN1A is also familial hemiplegic migraine locus FHM3

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4919188

Antiepileptic drugs in migraine: from clinical aspects to cellular mechanisms

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4919188

Newer antiepileptic drugs: possible uses in the treatment of neuropathic pain and migraine

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4919188

Novel tarantula toxins for subtypes of voltage-dependent potassium channels in the Kv2 and Kv4 subfamilies

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4919188

Does the right side know what the left is doing?

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4919188

Combinatorial peptide libraries in drug design: lessons from venomous cone snails

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4919188

A novel potassium channel with delayed rectifier properties isolated from rat brain by expression cloning

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4919188

De novo expression of Nav1.7 in injured putative proprioceptive afferents: Multiple tetrodotoxin-sensitive sodium channels are retained in the rat dorsal root after spinal nerve ligation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4919188

Unbiased classification of sensory neuron types by large-scale single-cell RNA sequencing

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4919188

Rufinamide attenuates mechanical allodynia in a model of neuropathic pain in the mouse and stabilizes voltage-gated sodium channel inactivated state

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4919188

Restriction of Transient Receptor Potential Vanilloid-1 to the Peptidergic Subset of Primary Afferent Neurons Follows Its Developmental Downregulation in Nonpeptidergic Neurons

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4919188

Hanatoxin modifies the gating of a voltage-dependent K+ channel through multiple binding sites

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4919188

Sensory receptors in mammalian skin in an in vitro preparation.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4919188

Changes in the expression of tetrodotoxin-sensitive sodium channels within dorsal root ganglia neurons in inflammatory pain

3 June 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE17976

Spinal sensory neurons express multiple sodium channel alpha-subunit mRNAs

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE17976

The P2Y agonist UTP activates cutaneous afferent fibers

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE17976

Effect of prolonged nerve block on inflammatory hyperalgesia in rats: prevention of late hyperalgesia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE17976

Role of primary afferent nerves in allodynia caused by diabetic neuropathy in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE17976

A 'toothache tree' alkylamide inhibits Aδ mechanonociceptors to alleviate mechanical pain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE17976

Isolation, characterization and total regioselective synthesis of the novel μO-conotoxin MfVIA from Conus magnificus that targets voltage-gated sodium channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE17976

Post-inflammatory colonic afferent sensitisation: different subtypes, different pathways and different time courses

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE17976

Increased κ-opioid receptor expression and function during chronic visceral hypersensitivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE17976

Acid-Labile Cys-Protecting Groups for the Fmoc/tBu Strategy: Filling the Gap

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE17976

Selenoether oxytocin analogues have analgesic properties in a mouse model of chronic abdominal pain

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE17976

The 5-HT3 subtype of serotonin receptor contributes to nociceptive processing via a novel subset of myelinated and unmyelinated nociceptors.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4919188

Receptive properties of mouse sensory neurons innervating hairy skin

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4919188

Prostaglandin E2-induced sensitization of bradykinin-evoked responses in rat dorsal root ganglion neurons is mediated by cAMP-dependent protein kinase A

27 November 2018

1 reference

12 December 2020

Splanchnic and pelvic mechanosensory afferents signal different qualities of colonic stimuli in mice

1 reference

12 December 2020

Activating transcription factor 3 (ATF3) induction by axotomy in sensory and motoneurons: A novel neuronal marker of nerve injury

1 reference

12 December 2020

Therapeutic potential of Na(V)1.1 activators

1 reference

12 December 2020

Identifiers

DOI

10.1038/NATURE17976

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27281198%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

8 June 2020

1046710244

0 references

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27281198%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27281198%20AND%20SRC:MED&resulttype=core&format=json