Englerin A Agonizes the TRPC4/C5 Cation Channels to Inhibit Tumor Cell Line Proliferation (Q28548565)

0 references

Pichai Raman

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Jennifer Tullai

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Lei Xu

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Martin Henault

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Emily Thomas

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Sarita Yeola

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Jianmin Lao

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Mark McPate

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J Martin Verkuyl

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George Marsh

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Jason Sarber

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Adam Amaral

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Scott Bailey

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Danuta Lubicka

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Helen Pham

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Nicolette Miranda

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Jian Ding

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Hai-Ming Tang

0 references

Haisong Ju

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Pamela Tranter

0 references

Nan Ji

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Philipp Krastel

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Rishi K Jain

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Andrew M Schumacher

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Joseph J Loureiro

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Elizabeth George

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Giuliano Berellini

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Nathan T Ross

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Simon M Bushell

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Gül Erdemli

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Jonathan M Solomon

Creative Commons Attribution 4.0 International

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language of work or name

English

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publication date

2015

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e0127498

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start time

22 June 2015

1 reference

April 2022 Public Data File from Crossref

copyrighted

0 references

describes a project that uses

limma

object named as

limma

2 references

Europe PubMed Central

22 June 2022

https://europepmc.org/article/PMC/4476799

based on heuristic

inferred from PubMed Central ID database lookup

CZ Software Mentions: A large dataset of software mentions in the biomedical literature

cites work

TRPV1 structures in distinct conformations reveal activation mechanisms

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4476799

Structure of the TRPV1 ion channel determined by electron cryo-microscopy

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4476799

Design and optimization of selective protein kinase C θ (PKCθ) inhibitors for the treatment of autoimmune diseases

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4476799

Englerin A stimulates PKCθ to inhibit insulin signaling and to simultaneously activate HSF1: pharmacologically induced synthetic lethality

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4476799

Englerin a selectively induces necrosis in human renal cancer cells

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4476799

Established and emerging trends in computational drug discovery in the structural genomics era

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4476799

Essential role for TRPC5 in amygdala function and fear-related behavior.

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4476799

Corticolimbic expression of TRPC4 and TRPC5 channels in the rodent brain

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4476799

TRP channel activation by reversible covalent modification

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4476799

Human UDP-glucuronosyltransferases: metabolism, expression, and disease

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4476799

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4476799

Natural products as sources of new drugs over the 30 years from 1981 to 2010

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4476799

(-)-Englerin A is a potent and selective activator of TRPC4 and TRPC5 calcium channels

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4476799

Renal cancer-selective Englerin A induces multiple mechanisms of cell death and autophagy

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4476799

The yin and yang of protein kinase C-theta (PKCθ): a novel drug target for selective immunosuppression

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4476799

Natural products: a continuing source of novel drug leads

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4476799

Target identification for small bioactive molecules: finding the needle in the haystack

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4476799

Target identification of small molecules based on chemical biology approaches

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4476799

Administration of substances to laboratory animals: routes of administration and factors to consider.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4476799

Determining the mode of action of bioactive compounds.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4476799

Chemical synthesis of the englerins.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4476799

Cell proliferation, calcium influx and calcium channels

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4476799

GISTIC2.0 facilitates sensitive and confident localization of the targets of focal somatic copy-number alteration in human cancers

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4476799

The transient receptor potential family of ion channels

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4476799

Structural biology of TRP channels.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4476799

Cardiac Ion Channel Safety Profiling on the IonWorks Quattro Automated Patch Clamp System

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4476799

QPatch: the missing link between HTS and ion channel drug discovery.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4476799

Englerin A, a selective inhibitor of renal cancer cell growth, from Phyllanthus engleri.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4476799

Ca2+ signalling checkpoints in cancer: remodelling Ca2+ for cancer cell proliferation and survival

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4476799

Ionic channels formed by TRPC4.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4476799

The mammalian TRPC cation channels

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4476799

TRPC4 and TRPC4-deficient mice.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4476799

TRPC4 and TRPC5: receptor-operated Ca2+-permeable nonselective cation channels

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4476799

The TRP ion channel family.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4476799

Intracellular calcium strongly potentiates agonist-activated TRPC5 channels.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4476799

Total synthesis and absolute configuration of the guaiane sesquiterpene englerin A.

3 June 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0127498

A Brief Synthesis of (−)-Englerin A

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0127498

Discovery, optimization, and biological evaluation of 5-(2-(trifluoromethyl)phenyl)indazoles as a novel class of transient receptor potential A1 (TRPA1) antagonists.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0127498

Expression of TRPC homologs in endothelial cells and smooth muscle layers of human arteries.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0127498

Species difference of esterase expression and hydrolase activity in plasma

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26098886

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Impairment of store-operated Ca2+ entry in TRPC4(-/-) mice interferes with increase in lung microvascular permeability

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26098886

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1371/JOURNAL.PONE.0127498

1 reference

ADS bibcode

2015PLoSO..1027498C

0 references

1 reference

1 reference

PubMed publication ID

26098886

1 reference