Mechanical stimuli induce cleavage and nuclear translocation of the polycystin-1 C terminus (Q28506516)

24 January 2017

title

Mechanical stimuli induce cleavage and nuclear translocation of the polycystin-1 C terminus (English)

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Polycystin 1, transient receptor potential channel interacting

24 January 2017

main subject

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GOA release 2020-03-11

Veronique Chauvet

1 reference

24 January 2017

Xin Tian

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24 January 2017

Herve Husson

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24 January 2017

David H. Grimm

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24 January 2017

Tong Wang

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24 January 2017

Thomas Hiesberger

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24 January 2017

Thomas Hieseberger

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24 January 2017

Peter Igarashi

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24 January 2017

Anton M. Bennett

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24 January 2017

Oxana Ibraghimov-Beskrovnaya

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24 January 2017

Stefan Somlo

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24 January 2017

Michael J. Caplan

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24 January 2017

language of work or name

English

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publication date

1 November 2004

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Journal of Clinical Investigation

24 January 2017

published in

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24 January 2017

volume

114

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24 January 2017

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24 January 2017

page(s)

1433–1443

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Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells

24 January 2017

cites work

1 reference

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Cleavage of polycystin-1 requires the receptor for egg jelly domain and is disrupted by human autosomal-dominant polycystic kidney disease 1-associated mutations.

19 March 2017

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Polycystin-2 localizes to kidney cilia and the ciliary level is elevated in orpk mice with polycystic kidney disease

19 March 2017

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PKD1 induces p21(waf1) and regulation of the cell cycle via direct activation of the JAK-STAT signaling pathway in a process requiring PKD2

19 March 2017

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Expression of PKD1 and PKD2 transcripts and proteins in human embryo and during normal kidney development

19 March 2017

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Polycystin-2 is an intracellular calcium release channel

19 March 2017

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Cystin, a novel cilia-associated protein, is disrupted in the cpk mouse model of polycystic kidney disease

19 March 2017

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gamma -Secretase cleavage and nuclear localization of ErbB-4 receptor tyrosine kinase

19 March 2017

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Chlamydomonas IFT88 and its mouse homologue, polycystic kidney disease gene tg737, are required for assembly of cilia and flagella

19 March 2017

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The Oak Ridge Polycystic Kidney (orpk) disease gene is required for left-right axis determination

19 March 2017

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Regulated intramembrane proteolysis: a control mechanism conserved from bacteria to humans

19 March 2017

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Homo- and heterodimeric interactions between the gene products of PKD1 and PKD2

19 March 2017

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PKD1 interacts with PKD2 through a probable coiled-coil domain

19 March 2017

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PKD2, a gene for polycystic kidney disease that encodes an integral membrane protein

19 March 2017

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The polycystic kidney disease proteins, polycystin-1, polycystin-2, polaris, and cystin, are co-localized in renal cilia

19 March 2017

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AP-1 as a regulator of cell life and death

7 April 2017

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Co-assembly of polycystin-1 and -2 produces unique cation-permeable currents

7 April 2017

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The COOH-terminal tail of the GAT-2 GABA transporter contains a novel motif that plays a role in basolateral targeting

7 April 2017

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Transmembrane Domain Analysis of Polycystin-1, the Product of the Polycystic Kidney Disease-1 (PKD1) Gene: Evidence for 11 Membrane-Spanning Domains

29 September 2017

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Kidney-specific inactivation of the KIF3A subunit of kinesin-II inhibits renal ciliogenesis and produces polycystic kidney disease

29 September 2017

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Intramembrane proteolysis controls diverse signalling pathways throughout evolution

29 September 2017

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Polycystin-1 activation of c-Jun N-terminal kinase and AP-1 is mediated by heterotrimeric G proteins

29 September 2017

1 reference

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Polaris, a protein disrupted in orpk mutant mice, is required for assembly of renal cilium

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=525739

Bending the MDCK cell primary cilium increases intracellular calcium

29 September 2017

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Adhesion signaling: how beta-catenin interacts with its partners

29 September 2017

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Nuclear localization of EGF receptor and its potential new role as a transcription factor

29 September 2017

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Polycystin-1, the gene product of PKD1, induces resistance to apoptosis and spontaneous tubulogenesis in MDCK cells

29 September 2017

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Compromised cytoarchitecture and polarized trafficking in autosomal dominant polycystic kidney disease cells

29 September 2017

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Identification and characterization of polycystin-2, the PKD2 gene product

29 September 2017

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The polycystic kidney disease 1 gene product modulates Wnt signaling

29 September 2017

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Polycystin: in vitro synthesis, in vivo tissue expression, and subcellular localization identifies a large membrane-associated protein

29 September 2017

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Identification and localization of polycystin, the PKD1 gene product

29 September 2017

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Antineurogenic phenotypes induced by truncated Notch proteins indicate a role in signal transduction and may point to a novel function for Notch in nuclei

29 September 2017

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Intrinsic activity of the Lin-12 and Notch intracellular domains in vivo

29 September 2017

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Distribution and developmentally regulated expression of murine polycystin

29 September 2017

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Polycystin-1 distribution is modulated by polycystin-2 expression in mammalian cells

2 June 2018

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A human PKD1 transgene generates functional polycystin-1 in mice and is associated with a cystic phenotype

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=525739

Distinct and common developmental expression patterns of the murine Pkd2 and Pkd1 genes.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=525739

Murine Pkd1 is a developmentally regulated gene from morula to adulthood: role in tissue condensation and patterning

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=525739

Dysregulation of cellular proliferation and apoptosis mediates human autosomal dominant polycystic kidney disease (ADPKD).

27 November 2018

1 reference

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Polycystic kidney disease

27 November 2018

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12 December 2020

The effect of 2 hours of complete unilateral ureteral obstruction on tubuloglomerular feedback control

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12 December 2020

Analysis of the genomic sequence for the autosomal dominant polycystic kidney disease (PKD1) gene predicts the presence of a leucine-rich repeat. The American PKD1 Consortium (APKD1 Consortium)

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12 December 2020

The polycystic kidney disease 1 gene product mediates protein kinase C alpha-dependent and c-Jun N-terminal kinase-dependent activation of the transcription factor AP-1

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12 December 2020

Somatic inactivation of Pkd2 results in polycystic kidney disease

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12 December 2020

Biochemical characterization of bona fide polycystin-1 in vitro and in vivo

1 reference

12 December 2020