PKD1 induces p21(waf1) and regulation of the cell cycle via direct activation of the JAK-STAT signaling pathway in a process requiring PKD2 (Q28585618)

31 January 2017

title

PKD1 induces p21(waf1) and regulation of the cell cycle via direct activation of the JAK-STAT signaling pathway in a process requiring PKD2 (English)

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Polycystin 2, transient receptor potential cation channel

31 January 2017

main subject

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Polycystin 1, transient receptor potential channel interacting

GOA release 2020-03-11

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GOA release 2020-03-11

Alessandra Boletta

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31 January 2017

Anil Kumar Bhunia

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31 January 2017

Klaus Piontek

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31 January 2017

Lijuan Liu

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31 January 2017

Feng Qian

1 reference

31 January 2017

Pei Ning Xu

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31 January 2017

F. Joseph Germino

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31 January 2017

Gregory G. Germino

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31 January 2017

language of work or name

English

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publication date

19 April 2002

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31 January 2017

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31 January 2017

volume

109

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31 January 2017

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31 January 2017

page(s)

157–168

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Induction of epithelial tubules by growth factor HGF depends on the STAT pathway

31 January 2017

cites work

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7 January 2021

Polycystin-1, the gene product of PKD1, induces resistance to apoptosis and spontaneous tubulogenesis in MDCK cells

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7 January 2021

Cell growth arrest and induction of cyclin-dependent kinase inhibitor p21 WAF1/CIP1 mediated by STAT1.

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STATs and gene regulation

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Mice Lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control

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STAT signaling is active during early mammalian development.

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Targeted disruption of the mouse Stat1 gene results in compromised innate immunity to viral disease

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WAF1, a potential mediator of p53 tumor suppression

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7 January 2021

The polycystic kidney disease 1 gene encodes a 14 kb transcript and lies within a duplicated region on chromosome 16. The European Polycystic Kidney Disease Consortium

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B lymphocytes from patients with chronic lymphocytic leukemia contain signal transducer and activator of transcription (STAT) 1 and STAT3 constitutively phosphorylated on serine residues.

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Autosomal dominant polycystic kidney disease

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Polycystin-2, the protein mutated in autosomal dominant polycystic kidney disease (ADPKD), is a Ca2+-permeable nonselective cation channel

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Co-assembly of polycystin-1 and -2 produces unique cation-permeable currents

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The JAK-STAT pathway in Drosophila

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The polycystic kidney disease 1 (PKD1) gene encodes a novel protein with multiple cell recognition domains

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7 January 2021

Strong homophilic interactions of the Ig-like domains of polycystin-1, the protein product of an autosomal dominant polycystic kidney disease gene, PKD1

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7 January 2021

STATs: signal transducers and activators of transcription

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7 January 2021

CD45 is a JAK phosphatase and negatively regulates cytokine receptor signalling

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7 January 2021

Expression of differentiation antigens and growth-related genes in normal kidney, autosomal dominant polycystic kidney disease, and renal cell carcinoma

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Regulation of STAT-dependent pathways by growth factors and cytokines.

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Jaks and STATs: biological implications

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Perinatal lethality with kidney and pancreas defects in mice with a targetted Pkd1 mutation

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7 January 2021

Comparison of Pkd1-targeted mutants reveals that loss of polycystin-1 causes cystogenesis and bone defects

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7 January 2021

Transcriptional regulation of the cyclin D1 promoter by STAT5: its involvement in cytokine-dependent growth of hematopoietic cells

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7 January 2021

p21waf1 can block cells at two points in the cell cycle, but does not interfere with processive DNA-replication or stress-activated kinases

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7 January 2021

Targeted disruption of the Stat1 gene in mice reveals unexpected physiologic specificity in the JAK-STAT signaling pathway

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7 January 2021

PKD2, a gene for polycystic kidney disease that encodes an integral membrane protein

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Jak2 deficiency defines an essential developmental checkpoint in definitive hematopoiesis

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The molecular basis of focal cyst formation in human autosomal dominant polycystic kidney disease type I.

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PKD1 interacts with PKD2 through a probable coiled-coil domain

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7 January 2021

Identification of SH2-bbeta as a potent cytoplasmic activator of the tyrosine kinase Janus kinase 2.

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7 January 2021

Identification of SH2-Bbeta as a substrate of the tyrosine kinase JAK2 involved in growth hormone signaling

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7 January 2021

A common nuclear signal transduction pathway activated by growth factor and cytokine receptors

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7 January 2021

FGF signaling inhibits chondrocyte proliferation and regulates bone development through the STAT-1 pathway

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7 January 2021

Cytokine-inducible SH2 protein-3 (CIS3/SOCS3) inhibits Janus tyrosine kinase by binding through the N-terminal kinase inhibitory region as well as SH2 domain

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7 January 2021

Transcriptional responses to polypeptide ligands: the JAK-STAT pathway

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CDK inhibitors: positive and negative regulators of G1-phase progression

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A unique glucose-dependent apoptotic pathway induced by c-Myc

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Targeted disruption of the mouse Stat3 gene leads to early embryonic lethality

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7 January 2021

STAM, signal transducing adaptor molecule, is associated with Janus kinases and involved in signaling for cell growth and c-myc induction

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7 January 2021

Homo- and heterodimeric interactions between the gene products of PKD1 and PKD2

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7 January 2021

Specific association of the gene product of PKD2 with the TRPC1 channel

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7 January 2021

Mutations of PKD1 in ADPKD2 cysts suggest a pathogenic effect of trans-heterozygous mutations.

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7 January 2021

Apoptosis and loss of renal tissue in polycystic kidney diseases

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7 January 2021

Somatic inactivation of Pkd2 results in polycystic kidney disease

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7 January 2021

The JAK-binding protein JAB inhibits Janus tyrosine kinase activity through binding in the activation loop

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7 January 2021

The Janus kinase family of protein tyrosine kinases and their role in signaling

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7 January 2021

10.1016/S0092-8674(02)00716-X

Identifiers

DOI

1 reference

Consolidated OpenCitations Corpus – April 2017

1 reference

Consolidated OpenCitations Corpus – April 2017

1 reference

Consolidated OpenCitations Corpus – April 2017