The Wnt receptor, Lrp5, is expressed by mouse mammary stem cells and is required to maintain the basal lineage (Q28505604)

24 January 2017

title

The Wnt receptor, Lrp5, is expressed by mouse mammary stem cells and is required to maintain the basal lineage (English)

1 reference

Low density lipoprotein receptor-related protein 5

24 January 2017

main subject

1 reference

GOA release 2020-03-11

Nisha M. Badders

Nisha M

Badders

1 reference

24 January 2017

Shruti Goel

Shruti

Goel

1 reference

24 January 2017

Rod J. Clark

Rod J

Clark

1 reference

24 January 2017

Kristine S. Klos

Kristine S

Klos

1 reference

24 January 2017

Soyoung Kim

Soyoung

Kim

1 reference

24 January 2017

Anna Bafico

Anna

Bafico

1 reference

24 January 2017

Charlotta Lindvall

Charlotta

Lindvall

1 reference

24 January 2017

Bart O. Williams

Bart O

Williams

1 reference

24 January 2017

Caroline M. Alexander

Caroline M

Alexander

1 reference

24 January 2017

language of work or name

English

0 references

publication date

12 August 2009

1 reference

24 January 2017

1 reference

24 January 2017

1 reference

24 January 2017

1 reference

24 January 2017

page(s)

e6594

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Creative Commons Attribution 4.0 International

24 January 2017

start time

12 August 2009

1 reference

April 2022 Public Data File from Crossref

copyrighted

0 references

cites work

The Wnt co-receptor Lrp6 is required for normal mouse mammary gland development

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Where Wnts went: the exploding field of Lrp5 and Lrp6 signaling in bone

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The extracellular domain of Lrp5/6 inhibits noncanonical Wnt signaling in vivo

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A model for familial exudative vitreoretinopathy caused by LPR5 mutations

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Wnt5a is required for proper mammary gland development and TGF-beta-mediated inhibition of ductal growth

19 March 2017

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R-Spondin1 regulates Wnt signaling by inhibiting internalization of LRP6

19 March 2017

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The Wnt signaling receptor Lrp5 is required for mammary ductal stem cell activity and Wnt1-induced tumorigenesis

19 March 2017

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Purified Wnt5a protein activates or inhibits beta-catenin-TCF signaling depending on receptor context

19 March 2017

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p63 regulates multiple signalling pathways required for ectodermal organogenesis and differentiation

19 March 2017

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p63 deficiency activates a program of cellular senescence and leads to accelerated aging

19 March 2017

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Decreased BMD and limb deformities in mice carrying mutations in both Lrp5 and Lrp6

19 March 2017

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The Wnt co-receptors Lrp5 and Lrp6 are essential for gastrulation in mice

19 March 2017

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19 March 2017

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Mammary gland development requires syndecan-1 to create a beta-catenin/TCF-responsive mammary epithelial subpopulation

19 March 2017

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Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes

19 March 2017

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Cbfa1-independent decrease in osteoblast proliferation, osteopenia, and persistent embryonic eye vascularization in mice deficient in Lrp5, a Wnt coreceptor

19 March 2017

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Molecular portraits of human breast tumours

19 March 2017

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Multiple roles for activated LEF/TCF transcription complexes during hair follicle development and differentiation

19 March 2017

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p63 is essential for regenerative proliferation in limb, craniofacial and epithelial development

19 March 2017

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Molecular cloning and characterization of LR3, a novel LDL receptor family protein with mitogenic activity

19 March 2017

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p63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominant-negative activities

19 March 2017

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Cloning of a novel member of the low-density lipoprotein receptor family

19 March 2017

1 reference

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Isolation and characterization of LRP6, a novel member of the low density lipoprotein receptor gene family

19 March 2017

1 reference

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Wnt signaling: a common theme in animal development

19 March 2017

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Increasing p16INK4a expression decreases forebrain progenitors and neurogenesis during ageing

7 April 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2720450

Generation of a functional mammary gland from a single stem cell

7 April 2017

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Purification and unique properties of mammary epithelial stem cells

7 April 2017

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Maintenance of pluripotency in human and mouse embryonic stem cells through activation of Wnt signaling by a pharmacological GSK-3-specific inhibitor

7 April 2017

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Wnt proteins are lipid-modified and can act as stem cell growth factors

7 April 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2720450

Wnt signalling and its impact on development and cancer

7 April 2017

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Caught up in a Wnt storm: Wnt signaling in cancer

7 April 2017

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WNT signals are required for the initiation of hair follicle development

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2720450

The internally truncated LRP5 receptor presents a therapeutic target in breast cancer

7 April 2017

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Integrins in mammary-stem-cell biology and breast-cancer progression--a role in cancer stem cells?

29 September 2017

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Detection and analysis of mammary gland stem cells

29 September 2017

1 reference

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Wnt-signaling and senescence: A tug of war in early neoplasia?

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2720450

The WNT signalling pathway and diabetes mellitus

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2720450

WNT signaling in stem cell biology and regenerative medicine

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2720450

Wnt3a and Dkk1 regulate distinct internalization pathways of LRP6 to tune the activation of beta-catenin signaling

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2720450

Beta1 integrin deletion from the basal compartment of the mammary epithelium affects stem cells

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2720450

Non-conventional Frizzled ligands and Wnt receptors.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2720450

Relationships between stem cell exhaustion, tumour suppression and ageing

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2720450

Analysis of endogenous LRP6 function reveals a novel feedback mechanism by which Wnt negatively regulates its receptor

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2720450

Identification of conserved gene expression features between murine mammary carcinoma models and human breast tumors

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2720450

LRP6 mutation in a family with early coronary disease and metabolic risk factors

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2720450

TAp63 and DeltaNp63 in cancer and epidermal development

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2720450

The regulation of INK4/ARF in cancer and aging

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2720450

Mechanisms of disease: from stem cells to colorectal cancer.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2720450

Redundant expression of canonical Wnt ligands in human breast cancer cell lines

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2720450

TAp63alpha induces apoptosis by activating signaling via death receptors and mitochondria

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2720450

Wnt control of stem cells and differentiation in the intestinal epithelium

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2720450

Beta1 integrins regulate mammary gland proliferation and maintain the integrity of mammary alveoli

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2720450

LRP5 and Wnt signaling: a union made for bone

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2720450

Wnt proteins in mammary development and cancer

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2720450

The transforming activity of Wnt effectors correlates with their ability to induce the accumulation of mammary progenitor cells

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2720450

Regulation of hematopoietic stem cell self-renewal

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2720450

DeltaNp63alpha and TAp63alpha regulate transcription of genes with distinct biological functions in cancer and development

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2720450

WNT signaling and lymphocyte development

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2720450

New aspects of Wnt signaling pathways in higher vertebrates

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2720450

Characterisation of Wnt gene expression during the differentiation of murine embryonic stem cells in vitro: role of Wnt3 in enhancing haematopoietic differentiation.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2720450

p63 identifies keratinocyte stem cells

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2720450

An arrow for wingless to take-off

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2720450

Expression of the type I diabetes-associated gene LRP5 in macrophages, vitamin A system cells, and the Islets of Langerhans suggests multiple potential roles in diabetes

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2720450

Cytoskeletal reorganization by soluble Wnt-3a protein signalling

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2720450

Wingless/Wnt signal transduction requires distinct initiation and amplification steps that both depend on Arrow/LRP.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2720450

Wnt-10b directs hypermorphic development and transformation in mammary glands of male and female mice

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2720450

Developmental and hormonal regulation of Wnt gene expression in the mouse mammary gland.

2 June 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0006594

Localization and quantification of Wnt-2 gene expression in mouse mammary development

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0006594

Regulated proteolytic processing of LRP6 results in release of its intracellular domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0006594

Simulating mouse mammary gland development: cell ageing and its relation to stem and progenitor activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0006594

Stem-cell ageing modified by the cyclin-dependent kinase inhibitor p16INK4a

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2720450

DeltaNp63 induces beta-catenin nuclear accumulation and signaling

27 November 2018

1 reference

12 December 2020

An entire functional mammary gland may comprise the progeny from a single cell

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12 December 2020

Extracellular matrix selectively modulates the response of mammary epithelial cells to different soluble signaling ligands

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12 December 2020

Syndecan-1 is required for Wnt-1-induced mammary tumorigenesis in mice

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12 December 2020

10.1371/JOURNAL.PONE.0006594

Identifiers

DOI

1 reference

ADS bibcode

2009PLoSO...4.6594B

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