Where Wnts went: the exploding field of Lrp5 and Lrp6 signaling in bone (Q28303536)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19072724%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

review article

3 references

26 August 2020

1 September 2020

Where Wnts went: the exploding field of Lrp5 and Lrp6 signaling in bone (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19072724%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

main subject

cell surface receptor

1 reference

PubMed

human musculoskeletal system

31 July 2019

1 reference

6 October 2019

1 reference

11 October 2019

LDL-receptor related proteins

1 reference

15 December 2019

1 reference

15 December 2019

1 reference

26 August 2020

1 reference

1 September 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19072724%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19072724%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

author name string

Bart O Williams

series ordinal

0 references

Karl L Insogna

series ordinal

0 references

language of work or name

English

0 references

publication date

1 February 2009

7 references

31 July 2019

6 October 2019

11 October 2019

15 December 2019

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19072724%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

26 August 2020

1 September 2020

Journal of Bone and Mineral Research

7 references

31 July 2019

6 October 2019

11 October 2019

15 December 2019

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19072724%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

26 August 2020

1 September 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19072724%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

issue

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19072724%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

page(s)

171-178

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19072724%20AND%20SRC:MED&resulttype=core&format=json

Creative Commons Attribution 2.5 Generic

18 January 2020

6 references

31 July 2019

6 October 2019

11 October 2019

15 December 2019

26 August 2020

Lrp5 controls bone formation by inhibiting serotonin synthesis in the duodenum

1 September 2020

cites work

1 reference

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Control of bone mass and remodeling by PTH receptor signaling in osteocytes

20 March 2017

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Mechanical stimulation of bone in vivo reduces osteocyte expression of Sost/sclerostin

20 March 2017

1 reference

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An LRP5 receptor with internal deletion in hyperparathyroid tumors with implications for deregulated WNT/beta-catenin signaling

20 March 2017

1 reference

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Endocrine regulation of energy metabolism by the skeleton

20 March 2017

1 reference

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Patients with high bone mass phenotype exhibit enhanced osteoblast differentiation and inhibition of adipogenesis of human mesenchymal stem cells

20 March 2017

1 reference

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The ups and downs of Wnt signaling in prevalent neurological disorders

20 March 2017

1 reference

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TSC2 integrates Wnt and energy signals via a coordinated phosphorylation by AMPK and GSK3 to regulate cell growth

20 March 2017

1 reference

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The Wnt co-receptor LRP5 is essential for skeletal mechanotransduction but not for the anabolic bone response to parathyroid hormone treatment

20 March 2017

1 reference

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Functional candidate genes in age-related macular degeneration: significant association with VEGF, VLDLR, and LRP6

20 March 2017

1 reference

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Lipoprotein particles are required for Hedgehog and Wingless signalling

20 March 2017

1 reference

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Wnt/beta-catenin signaling in mesenchymal progenitors controls osteoblast and chondrocyte differentiation during vertebrate skeletogenesis

20 March 2017

1 reference

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Autosomal recessive familial exudative vitreoretinopathy is associated with mutations in LRP5.

20 March 2017

1 reference

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20 March 2017

1 reference

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Vascular development in the retina and inner ear: control by Norrin and Frizzled-4, a high-affinity ligand-receptor pair

20 March 2017

1 reference

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Mutations in LRP5 or FZD4 underlie the common familial exudative vitreoretinopathy locus on chromosome 11q.

20 March 2017

1 reference

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The role of the Wnt-signaling antagonist DKK1 in the development of osteolytic lesions in multiple myeloma

20 March 2017

1 reference

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High bone mass in mice expressing a mutant LRP5 gene

20 March 2017

1 reference

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Six novel missense mutations in the LDL receptor-related protein 5 (LRP5) gene in different conditions with an increased bone density

20 March 2017

1 reference

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Low-density lipoprotein receptor-related protein 5 (LRP5) is essential for normal cholesterol metabolism and glucose-induced insulin secretion

20 March 2017

1 reference

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High bone density due to a mutation in LDL-receptor-related protein 5

20 March 2017

1 reference

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A mutation in the LDL receptor-related protein 5 gene results in the autosomal dominant high-bone-mass trait

20 March 2017

1 reference

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20 March 2017

1 reference

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Molecular cloning of mouse Lrp7(Lr3) cDNA and chromosomal mapping of orthologous genes in mouse and human

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3276354

Molecular cloning and characterization of LR3, a novel LDL receptor family protein with mitogenic activity

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3276354

Cloning of a novel member of the low-density lipoprotein receptor family

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3276354

Isolation and characterization of LRP6, a novel member of the low density lipoprotein receptor gene family

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3276354

Lrp6 hypomorphic mutation affects bone mass through bone resorption in mice and impairs interaction with Mesd

20 March 2017

1 reference

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WNT7b mediates macrophage-induced programmed cell death in patterning of the vasculature

20 March 2017

1 reference

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Crooked tail (Cd) model of human folate-responsive neural tube defects is mutated in Wnt coreceptor lipoprotein receptor-related protein 6.

20 March 2017

1 reference

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Canonical Wnt signaling in differentiated osteoblasts controls osteoclast differentiation

20 March 2017

1 reference

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Canonical Wnt/beta-catenin signaling prevents osteoblasts from differentiating into chondrocytes

20 March 2017

1 reference

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Sequential roles of Hedgehog and Wnt signaling in osteoblast development

20 March 2017

1 reference

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Decreased BMD and limb deformities in mice carrying mutations in both Lrp5 and Lrp6

20 March 2017

1 reference

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The Wnt antagonist secreted frizzled-related protein-1 is a negative regulator of trabecular bone formation in adult mice

20 March 2017

1 reference

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Parathyroid hormone signaling through low-density lipoprotein-related protein 6

20 March 2017

1 reference

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Essential role of beta-catenin in postnatal bone acquisition

20 March 2017

1 reference

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Skeletal defects in ringelschwanz mutant mice reveal that Lrp6 is required for proper somitogenesis and osteogenesis

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3276354

The Wnt co-receptors Lrp5 and Lrp6 are essential for gastrulation in mice

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3276354

Cbfa1-independent decrease in osteoblast proliferation, osteopenia, and persistent embryonic eye vascularization in mice deficient in Lrp5, a Wnt coreceptor

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3276354

An LDL-receptor-related protein mediates Wnt signalling in mice

20 March 2017

1 reference

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A second canon. Functions and mechanisms of beta-catenin-independent Wnt signaling

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3276354

Wnt3a-mediated formation of phosphatidylinositol 4,5-bisphosphate regulates LRP6 phosphorylation

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3276354

DKK1 antagonizes Wnt signaling without promotion of LRP6 internalization and degradation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3276354

Bone mineral density, osteoporosis, and osteoporotic fractures: a genome-wide association study.

29 September 2017

1 reference

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Rac1 activation controls nuclear localization of beta-catenin during canonical Wnt signaling.

29 September 2017

1 reference

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Non-conventional Frizzled ligands and Wnt receptors.

29 September 2017

1 reference

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Large-scale analysis of association between LRP5 and LRP6 variants and osteoporosis

29 September 2017

1 reference

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Sclerosing bone disorders

29 September 2017

1 reference

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Wnt signaling inside the nucleus

29 September 2017

1 reference

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The functions and possible significance of Kremen as the gatekeeper of Wnt signalling in development and pathology

29 September 2017

1 reference

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Wnt signaling, stem cells, and the cellular origin of breast cancer.

29 September 2017

1 reference

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Wnt/beta-catenin signaling and cardiogenesis: timing does matter

29 September 2017

1 reference

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LRP6 mutation in a family with early coronary disease and metabolic risk factors

29 September 2017

1 reference

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Structure-based mutation analysis shows the importance of LRP5 beta-propeller 1 in modulating Dkk1-mediated inhibition of Wnt signaling

29 September 2017

1 reference

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Effect of selective serotonin reuptake inhibitors on the risk of fracture

29 September 2017

1 reference

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The many ways of Wnt in cancer

29 September 2017

1 reference

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Function and biological roles of the Dickkopf family of Wnt modulators

29 September 2017

1 reference

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Verification of predicted alternatively spliced Wnt genes reveals two new splice variants (CTNNB1 and LRP5) and altered Axin-1 expression during tumour progression

29 September 2017

1 reference

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WNT/Frizzled signaling in eye development and disease

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3276354

Complexity of the genotype-phenotype correlation in familial exudative vitreoretinopathy with mutations in the LRP5 and/or FZD4 genes

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3276354

SOST is a target gene for PTH in bone

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3276354

SOST/sclerostin, an osteocyte-derived negative regulator of bone formation

29 September 2017

1 reference

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Mesd encodes an LRP5/6 chaperone essential for specification of mouse embryonic polarity

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3276354

Characterization of the Kremen-binding site on Dkk1 and elucidation of the role of Kremen in Dkk-mediated Wnt antagonism

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3276354

Noncanonical Wnt signaling through G protein-linked PKCdelta activation promotes bone formation

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3276354

Context-dependent activation or inhibition of Wnt-beta-catenin signaling by Kremen.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3276354

A histone lysine methyltransferase activated by non-canonical Wnt signalling suppresses PPAR-gamma transactivation

27 November 2018

1 reference

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Osteoblast-targeted expression of Sfrp4 in mice results in low bone mass.

27 November 2018

1 reference

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Association of low bone mineral density with selective serotonin reuptake inhibitor use by older men.

27 November 2018

1 reference

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Use of antidepressants and rates of hip bone loss in older women: the study of osteoporotic fractures

27 November 2018

1 reference

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Dkk2 has a role in terminal osteoblast differentiation and mineralized matrix formation

27 November 2018

1 reference

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Torus palatinus: a new anatomical correlation with bone density in postmenopausal women.

27 November 2018

1 reference

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Severe hypercholesterolemia, impaired fat tolerance, and advanced atherosclerosis in mice lacking both low density lipoprotein receptor-related protein 5 and apolipoprotein E.

27 November 2018

1 reference

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A new low density lipoprotein receptor related protein, LRP5, is expressed in hepatocytes and adrenal cortex, and recognizes apolipoprotein E.

27 November 2018

1 reference

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Deletion of a single allele of the Dkk1 gene leads to an increase in bone formation and bone mass

27 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19072724

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1359/JBMR.081235

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19072724%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19072724%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

PubMed publication ID

19072724

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19072724%20AND%20SRC:MED&resulttype=core&format=json