Vandetanib (Zactima, ZD6474) antagonizes ABCC1- and ABCG2-mediated multidrug resistance by inhibition of their transport function (Q28475378)

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Fang Wang

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Yu-hong Li

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Xu Zhang

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Li-ming Chen

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Yong-ju Liang

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Chun-ling Dai

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Yan-yan Yan

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Li-yang Tao

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Yan-jun Mi

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An-kui Yang

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Li-wu Fu

Creative Commons Attribution 4.0 International

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language of work or name

English

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publication date

2009

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e5172

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start time

23 April 2009

1 reference

April 2022 Public Data File from Crossref

copyrighted

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cites work

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Synergistic antitumor activity of ZD6474, an inhibitor of vascular endothelial growth factor receptor and epidermal growth factor receptor signaling, with gemcitabine and ionizing radiation against pancreatic cancer.

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ZD6474, an inhibitor of vascular endothelial growth factor receptor tyrosine kinase, inhibits growth of experimental lung metastasis and production of malignant pleural effusions in a non-small cell lung cancer model

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Antitumor vascular strategy for controlling experimental metastatic spread of human small-cell lung cancer cells with ZD6474 in natural killer cell-depleted severe combined immunodeficient mice.

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ZD6474 inhibits proliferation and invasion of human hepatocellular carcinoma cells

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29 September 2017

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ZD6474, an orally available inhibitor of KDR tyrosine kinase activity, efficiently blocks oncogenic RET kinases.

29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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Molecular cloning of cDNAs which are highly overexpressed in mitoxantrone-resistant cells: demonstration of homology to ABC transport genes

29 September 2017

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29 September 2017

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Non-P-glycoprotein-mediated multidrug-resistant human KB cells selected in medium containing adriamycin, cepharanthine, and mezerein.

2 June 2018

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21 January 2018

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Clinical evaluation of ZD6474, an orally active inhibitor of VEGF and EGF receptor signaling, in patients with solid, malignant tumors

21 January 2018

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21 January 2018

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21 January 2018

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ZD6474, a vascular endothelial growth factor receptor tyrosine kinase inhibitor with additional activity against epidermal growth factor receptor tyrosine kinase, inhibits orthotopic growth and angiogenesis of gastric cancer.

21 January 2018

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27 November 2018

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27 November 2018

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