A role for LKB1 gene in human cancer beyond the Peutz-Jeghers syndrome (Q28307804)

https://api.crossref.org/works/10.1038/SJ.ONC.1210594

MO25alpha/beta interact with STRADalpha/beta enhancing their ability to bind, activate and localize LKB1 in the cytoplasm

20 April 2017

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1210594

Search for the second Peutz-Jeghers syndrome locus: exclusion of the STK13, PRKCG, KLK10, and PSCD2 genes on chromosome 19 and the STK11IP gene on chromosome 2

20 April 2017

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1210594

Novel and natural knockout lung cancer cell lines for the LKB1/STK11 tumor suppressor gene

20 April 2017

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1210594

Somatic mutation of the Peutz-Jeghers syndrome gene, LKB1/STK11, in malignant melanoma

20 April 2017

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1210594

par-1, a gene required for establishing polarity in C. elegans embryos, encodes a putative Ser/Thr kinase that is asymmetrically distributed

20 April 2017

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1210594

Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade

20 April 2017

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1210594

Peutz-Jeghers syndrome is caused by mutations in a novel serine threoninekinase

20 April 2017

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1210594

The Peutz-Jegher gene product LKB1 is a mediator of p53-dependent cell death

20 April 2017

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1210594

Mutation and cancer: statistical study of retinoblastoma

20 April 2017

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1210594

LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1

20 April 2017

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1210594

LKB1 associates with Brg1 and is necessary for Brg1-induced growth arrest

20 April 2017

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1210594

Loss of LKB1 kinase activity in Peutz-Jeghers syndrome, and evidence for allelic and locus heterogeneity

20 April 2017

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1210594

The LKB1 tumor suppressor negatively regulates mTOR signaling

20 April 2017

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1210594

LKB1 exonic and whole gene deletions are a common cause of Peutz-Jeghers syndrome

20 April 2017

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1210594

Vascular abnormalities and deregulation of VEGF in Lkb1-deficient mice

20 April 2017

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1210594

Patterns of somatic mutation in human cancer genomes

20 April 2017

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210594

LKB1-dependent signaling pathways

20 April 2017

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210594

Mutation analysis of three genes encoding novel LKB1-interacting proteins, BRG1, STRADalpha, and MO25alpha, in Peutz-Jeghers syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210594

LKB1 somatic mutations in sporadic tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210594

Complete polarization of single intestinal epithelial cells upon activation of LKB1 by STRAD.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210594

Dysfunctional AMPK activity, signalling through mTOR and survival in response to energetic stress in LKB1-deficient lung cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210594

Somatic mutations in the STK11/LKB1 gene are uncommon in rare gynecological tumor types associated with Peutz-Jegher's syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210594

Identification and characterization of the tuberous sclerosis gene on chromosome 16

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210594

Regulation of the TSC pathway by LKB1: evidence of a molecular link between tuberous sclerosis complex and Peutz-Jeghers syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210594

Distinctive gene expression of human lung adenocarcinomas carrying LKB1 mutations.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210594

Very high risk of cancer in familial Peutz-Jeghers syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210594

Patterns of p53 G-->T transversions in lung cancers reflect the primary mutagenic signature of DNA-damage by tobacco smoke

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210594

Minireview: the AMP-activated protein kinase cascade: the key sensor of cellular energy status.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210594

Frequency and spectrum of cancers in the Peutz-Jeghers syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210594

Exonic STK11 deletions are not a rare cause of Peutz-Jeghers syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210594

Mutation analysis of 24 known cancer genes in the NCI-60 cell line set.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210594

Genetic analysis of the LKB1/STK11 gene in hepatocellular carcinomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210594

Mutations in the human LKB1/STK11 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210594

Relative frequency and morphology of cancers in STK11 mutation carriers

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210594

Expression of LKB1 and PTEN tumor suppressor genes during mouse embryonic development.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210594

A role for Drosophila LKB1 in anterior-posterior axis formation and epithelial polarity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210594

A novel mutation of STK11/LKB1 gene leads to the loss of cell growth inhibition in head and neck squamous cell carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210594

Induction of cyclooxygenase-2 in a mouse model of Peutz-Jeghers polyposis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210594

Somatic mutations in the Peutz-Jeghers (LKB1/STKII) gene in sporadic malignant melanomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210594

LKB1 kinase: master and commander of metabolism and polarity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210594

Germline and somatic mutations of the STK11/LKB1 Peutz-Jeghers gene in pancreatic and biliary cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210594

Growth suppression by Lkb1 is mediated by a G(1) cell cycle arrest

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210594

Growth arrest by the LKB1 tumor suppressor: induction of p21(WAF1/CIP1).

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210594

LKB1/STK11 suppresses cyclooxygenase-2 induction and cellular invasion through PEA3 in lung cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210594

Allele loss and mutation screen at the Peutz-Jeghers (LKB1) locus (19p13.3) in sporadic ovarian tumours.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210594

Mutations and impaired function of LKB1 in familial and non-familial Peutz-Jeghers syndrome and a sporadic testicular cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210594

Cigarette smoking is strongly associated with mutation of the K-ras gene in patients with primary adenocarcinoma of the lung

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210594

7 January 2021

Specific pattern of LKB1 and phospho-acetyl-CoA carboxylase protein immunostaining in human normal tissues and lung carcinomas

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210594

7 January 2021

A serine/threonine kinase gene defective in Peutz-Jeghers syndrome

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210594

7 January 2021

Generalized Intestinal Polyposis and Melanin Spots of the Oral Mucosa, Lips and Digits

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210594

7 January 2021

Mutations in the STK11 gene characterize minimal deviation adenocarcinoma of the uterine cervix.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210594

7 January 2021

Prevalence and specificity of LKB1 genetic alterations in lung cancers

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210594

7 January 2021

In situ analysis of LKB1/STK11 mRNA expression in human normal tissues and tumours

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210594

7 January 2021

Sensitive mutation detection in heterogeneous cancer specimens by massively parallel picoliter reactor sequencing

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210594

7 January 2021