The Peutz-Jegher gene product LKB1 is a mediator of p53-dependent cell death (Q24291382)

intrinsic apoptotic signaling pathway by p53 class mediator

GOA release 2020-03-11

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GOA release 2020-03-11

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O Gozani

Gozani

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ORCID Public Data File 2021

30 October 2023

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P Karuman

Karuman

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30 October 2023

R D Odze

R D

Odze

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30 October 2023

X C Zhou

X C

Zhou

1 reference

30 October 2023

H Zhu

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R Shaw

Shaw

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30 October 2023

T P Brien

T P

Brien

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30 October 2023

C D Bozzuto

C D

Bozzuto

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30 October 2023

D Ooi

Ooi

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30 October 2023

L C Cantley

L C

Cantley

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30 October 2023

J Yuan

Yuan

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p53 in signaling checkpoint arrest or apoptosis

30 October 2023

language of work or name

English

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publication date

June 2001

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1307-19

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cites work

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7 January 2021

p53 is associated with cellular microtubules and is transported to the nucleus by dynein

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Increased risk of cancer in the Peutz-Jeghers syndrome

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BCL-2 family members and the mitochondria in apoptosis

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Inactivation of Bcl-2 by phosphorylation

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The Hallmarks of Cancer

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Localization of a susceptibility locus for Peutz-Jeghers syndrome to 19p using comparative genomic hybridization and targeted linkage analysis

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7 January 2021

A serine/threonine kinase gene defective in Peutz-Jeghers syndrome

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Generalized Intestinal Polyposis and Melanin Spots of the Oral Mucosa, Lips and Digits

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Bax-deficient mice with lymphoid hyperplasia and male germ cell death

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p53-independent apoptosis induced by paclitaxel through an indirect mechanism

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Cleavage of p21Cip1/Waf1 and p27Kip1 mediates apoptosis in endothelial cells through activation of Cdk2: role of a caspase cascade

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7 January 2021

Cytochrome c and dATP-Dependent Formation of Apaf-1/Caspase-9 Complex Initiates an Apoptotic Protease Cascade

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7 January 2021

p53 is required for radiation-induced apoptosis in mouse thymocytes

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7 January 2021

Death signal-induced localization of p53 protein to mitochondria. A potential role in apoptotic signaling

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7 January 2021

Loss of LKB1 kinase activity in Peutz-Jeghers syndrome, and evidence for allelic and locus heterogeneity

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7 January 2021

Kinetics of mitotic arrest and apoptosis in murine mammary and ovarian tumors treated with taxol

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Nine novel germline mutations of STK11 in ten families with Peutz-Jeghers syndrome

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7 January 2021

Peutz-Jeghers disease: most, but not all, families are compatible with linkage to 19p13.3.

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The significance of spontaneous and induced apoptosis in the gastrointestinal tract of mice

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THE DEVELOPMENT AND CLINICAL UTILITY OF THE TAXANE CLASS OF ANTIMICROTUBULE CHEMOTHERAPY AGENTS

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7 January 2021

Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

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7 January 2021

The mouse Peutz-Jeghers syndrome gene Lkb1 encodes a nuclear protein kinase

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7 January 2021

Cancer and the Peutz-Jeghers syndrome

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In situ immunodetection of activated caspase-3 in apoptotic neurons in the developing nervous system

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7 January 2021

Cloning and characterization of a novel serine/threonine protein kinase expressed in early Xenopus embryos

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7 January 2021

Growth suppression by Lkb1 is mediated by a G(1) cell cycle arrest

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7 January 2021

P53 and beta catenin expression in chronic ulcerative colitis--associated polypoid dysplasia and sporadic adenomas: an immunohistochemical study

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Microtubule-interfering Agents Activate c-Jun N-terminal Kinase/Stress-activated Protein Kinase through Both Ras and Apoptosis Signal-regulating Kinase Pathways

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The eukaryotic protein kinase superfamily: kinase (catalytic) domain structure and classification 1

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