SIRT2 inhibition achieves neuroprotection by decreasing sterol biosynthesis (Q28279273)

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Judit Pallos

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Emmanuel Lambert

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Allison Amore

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Hilary Moffitt

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Donna L Smith

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Heike Runne

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Alexandre Kuhn

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Zhongmin Xiang

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Michele M Maxwell

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Steven A Reeves

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Leslie M Thompson

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J Lawrence Marsh

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Aleksey G Kazantsev

Proceedings of the National Academy of Sciences of the United States of America

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language of work or name

English

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publication date

27 April 2010

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published in

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volume

107

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issue

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page(s)

7927-32

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cites work

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Sirtuin 2, a mammalian homolog of yeast silent information regulator-2 longevity regulator, is an oligodendroglial protein that decelerates cell differentiation through deacetylating alpha-tubulin

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Histone deacetylase inhibitors arrest polyglutamine-dependent neurodegeneration in Drosophila

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29 September 2017

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Dysfunction of the cholesterol biosynthetic pathway in Huntington's disease.

21 January 2018

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Mutant huntingtin inhibits clathrin-independent endocytosis and causes accumulation of cholesterol in vitro and in vivo

21 January 2018

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Progressive dysfunction of the cholesterol biosynthesis pathway in the R6/2 mouse model of Huntington's disease.

21 January 2018

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Plasma 24S-hydroxycholesterol and caudate MRI in pre-manifest and early Huntington's disease.

21 January 2018

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Cyp46-mediated cholesterol loss promotes survival in stressed hippocampal neurons.

21 January 2018

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Histone Deacetylase Inhibition by Sodium Butyrate Chemotherapy Ameliorates the Neurodegenerative Phenotype in Huntington's Disease Mice

21 January 2018

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27 November 2018

Identifiers

DOI

10.1073/PNAS.1002924107

1 reference

ADS bibcode

2010PNAS..107.7927L

0 references

1 reference

1 reference

PubMed publication ID

20378838

1 reference