The dark side of C5a in sepsis (Q28252425)

Residues 21-30 within the extracellular N-terminal region of the C5a receptor represent a binding domain for the C5a anaphylatoxin

21 April 2017

1 reference

High mobility group 1 protein (HMG-1) stimulates proinflammatory cytokine synthesis in human monocytes

21 April 2017

1 reference

HMG-1 as a late mediator of endotoxin lethality in mice

21 April 2017

1 reference

Mitogen-activated Protein Kinase Activation Requires Two Signal Inputs from the Human Anaphylatoxin C5a Receptor

21 April 2017

1 reference

Efficacy and safety of recombinant human activated protein C for severe sepsis

21 April 2017

1 reference

2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference

21 April 2017

1 reference

Definitions for sepsis and organ failure.

21 April 2017

1 reference

Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/Society of Critical Care Medicine

31 March 2020

1 reference

Association between tumour necrosis factor in serum and fatal outcome in patients with meningococcal disease

31 March 2020

1 reference

Circulating interleukin-1 and tumor necrosis factor in septic shock and experimental endotoxin fever

31 March 2020

1 reference

Serum Cytokine Levels in Human Septic Shock

31 March 2020

1 reference

Clinical trials of immunomodulatory therapies in severe sepsis and septic shock

31 March 2020

1 reference

Novel strategies for the treatment of sepsis

31 March 2020

1 reference

Anti-c5a ameliorates coagulation/fibrinolytic protein changes in a rat model of sepsis

31 March 2020

1 reference

Protective effects of anti-C5a in sepsis-induced thymocyte apoptosis

31 March 2020

1 reference

Regulation by complement C3a and C5a anaphylatoxins of cytokine production in human umbilical vein endothelial cells

31 March 2020

1 reference

Complement c3a and c5a induce different signal transduction cascades in endothelial cells

31 March 2020

1 reference

Expression and function of the C5a receptor in rat alveolar epithelial cells

31 March 2020

1 reference

Expression and function of C5a receptor in mouse microvascular endothelial cells

31 March 2020

1 reference

In vitro Responses of Human Asthmatic Airway and Pulmonary Vascular Smooth Muscle

31 March 2020

1 reference

Phagocytosis of Legionella pneumophila is mediated by human monocyte complement receptors

31 March 2020

1 reference

Activation of the fifth component of human complement, C5, without cleavage, by methionine oxidizing agents

31 March 2020

1 reference

The cobra complement system: I. The alternative pathway of activation

31 March 2020

1 reference

Studies of group B streptococcal infection in mice deficient in complement component C3 or C4 demonstrate an essential role for complement in both innate and acquired immunity

31 March 2020

1 reference

Immunoglobulin G-mediated inflammatory responses develop normally in complement-deficient mice

31 March 2020

1 reference

Modulation of immune complex-induced inflammation in vivo by the coordinate expression of activation and inhibitory Fc receptors.

31 March 2020

1 reference

The role of complement in inflammation and adaptive immunity

31 March 2020

1 reference

Role for the alternative complement pathway in ischemia/reperfusion injury

31 March 2020

1 reference

31 March 2020

Complement deficiencies

1 reference

Complement and renal disease.

31 March 2020

1 reference

Chemotactic and anaphylatoxic fragment cleaved from the fifth component of guinea pig complement

31 March 2020

1 reference

Demonstration of specific C5a receptor on intact human polymorphonuclear leukocytes

31 March 2020

1 reference

Structure-function relationships of human C5a and C5aR.

31 March 2020

1 reference

Two-site binding of C5a by its receptor: an alternative binding paradigm for G protein-coupled receptors

31 March 2020

1 reference

Site-directed mutagenesis of conserved charged residues in the helical region of the human C5a receptor. Arg2O6 determines high-affinity binding sites of C5a receptor

31 March 2020

1 reference

Epitope mapping of a C5a neutralizing mAb using a combined approach of phage display, synthetic peptides and site-directed mutagenesis

31 March 2020

1 reference

Role of the second extracellular loop of human C3a receptor in agonist binding and receptor function

31 March 2020

1 reference

Complement-induced impairment of innate immunity during sepsis

31 March 2020

1 reference

Arachidonic acid triggers an oxidative burst in leukocytes

31 March 2020

1 reference

The anaphylatoxins C3a and C5a are vasodilators in the canine coronary vasculaturein vitro andin vivo

31 March 2020

1 reference

Oxygen radicals mediate endothelial cell damage by complement-stimulated granulocytes. An in vitro model of immune vascular damage

31 March 2020

1 reference

C5a delays apoptosis of human neutrophils by a phosphatidylinositol 3-kinase-signaling pathway

31 March 2020

1 reference

C3a and C5a enhance granulocyte adhesion to endothelial and epithelial cell monolayers: epithelial and endothelial priming is required for C3a-induced eosinophil adhesion

31 March 2020

1 reference

Immunocomplexes stimulate different signalling events to chemoattractants in the neutrophil and regulate L-selectin and beta 2-integrin expression differently

31 March 2020

1 reference

C5a-induced expression of P-selectin in endothelial cells

31 March 2020

1 reference

Inhibition of interleukin-6 synthesis in an animal model of septic shock by anti-C5a monoclonal antibodies

31 March 2020

1 reference

Systemic and lung physiological changes in rats after intravascular activation of complement

31 March 2020

1 reference

Complement levels in septic primates treated with anti-C5a antibodies

31 March 2020

1 reference

Effects of anti-C5a antibodies on the adult respiratory distress syndrome in septic primates

31 March 2020

1 reference

Protective effects of C5a blockade in sepsis

31 March 2020

1 reference

Role of C5a in multiorgan failure during sepsis

31 March 2020

1 reference

Complement activation and endotoxin levels in systemic meningococcal disease

31 March 2020

1 reference

Complement activation and polymorphonuclear neutrophil leukocyte elastase in sepsis. Correlation with severity of disease.

31 March 2020

1 reference

Complement C5a in the sepsis syndrome--too much of a good thing?

31 March 2020

1 reference

Neutrophil C5a receptor and the outcome in a rat model of sepsis

31 March 2020

1 reference

Alteration of chemoattractant receptor expression regulates human neutrophil chemotaxis in vivo

31 March 2020

1 reference

Regulation by C5a of neutrophil activation during sepsis

31 March 2020

1 reference

C5 chemotactic fragment induces leukocyte production of tissue factor activity: a link between complement and coagulation

31 March 2020

1 reference

The role of the endothelium in severe sepsis and multiple organ dysfunction syndrome

31 March 2020

1 reference

Sepsis-induced apoptosis causes progressive profound depletion of B and CD4+ T lymphocytes in humans

31 March 2020

1 reference

Caspase inhibitors improve survival in sepsis: a critical role of the lymphocyte

31 March 2020

1 reference

C5a receptor and thymocyte apoptosis in sepsis

31 March 2020

1 reference

Increased C5a receptor expression in sepsis

31 March 2020

1 reference

Protective effects of IL-6 blockade in sepsis are linked to reduced C5a receptor expression

31 March 2020

1 reference

The acute phase protein response in patients receiving subcutaneous IL-6.

31 March 2020

1 reference

Protection of innate immunity by C5aR antagonist in septic mice

31 March 2020

1 reference

Effects of a new C5a receptor antagonist on C5a- and endotoxin-induced neutropenia in the rat.

31 March 2020

1 reference

Regulation of DNA-dependent activities by the functional motifs of the high-mobility-group chromosomal proteins

31 March 2020

1 reference

Inflammation-promoting activity of HMGB1 on human microvascular endothelial cells

31 March 2020

1 reference

Macrophage migration inhibitory factor (MIF): Its potential role in tumor growth and tumor-associated angiogenesis

31 March 2020

1 reference

Macrophage migration inhibitory factor is a critical mediator of systemic inflammatory response syndrome

31 March 2020

1 reference

Protection from septic shock by neutralization of macrophage migration inhibitory factor

31 March 2020

1 reference

Passive immunization against cachectin/tumor necrosis factor protects mice from lethal effect of endotoxin

31 March 2020

1 reference

Anti-cachectin/TNF monoclonal antibodies prevent septic shock during lethal bacteraemia

31 March 2020

1 reference

Endotoxin, TNF-alpha, interleukin-6 and parameters of the cellular immune system in patients with intraabdominal sepsis

31 March 2020

1 reference

Cleavage of the fifth component of complement and generation of a functionally active C5b6-like complex by human leukocyte elastase

31 March 2020

1 reference

Generation of C5a by phagocytic cells

31 March 2020

1 reference

G alpha 16, a G protein alpha subunit specifically expressed in hematopoietic cells

31 March 2020

1 reference

Pertussis toxin-sensitive activation of phospholipase C by the C5a and fMet-Leu-Phe receptors

31 March 2020

1 reference

Anti-tumor necrosis factor therapy in sepsis: update on clinical trials and lessons learned

31 March 2020

1 reference

Adjunctive therapy in sepsis: a critical analysis of the clinical trial programme

31 March 2020

1 reference

C1 inhibitor prevents endotoxin shock via a direct interaction with lipopolysaccharide

31 March 2020

1 reference

Confirmatory interleukin-1 receptor antagonist trial in severe sepsis: a phase III, randomized, double-blind, placebo-controlled, multicenter trial. The Interleukin-1 Receptor Antagonist Sepsis Investigator Group

31 March 2020

1 reference

Confirmatory platelet-activating factor receptor antagonist trial in patients with severe gram-negative bacterial sepsis: a phase III, randomized, double-blind, placebo-controlled, multicenter trial. BN 52021 Sepsis Investigator Group

31 March 2020

1 reference

A multi-centre, double-blind, placebo-controlled study of liposomal prostaglandin E1 (TLC C-53) in patients with acute respiratory distress syndrome

31 March 2020

1 reference

A double-blind, prospective, randomized trial of ketoconazole, a thromboxane synthetase inhibitor, in the prophylaxis of the adult respiratory distress syndrome.

31 March 2020

1 reference

Prolonged inhibition of nitric oxide synthesis in severe septic shock: a clinical study

31 March 2020

1 reference

Caring for the critically ill patient. High-dose antithrombin III in severe sepsis: a randomized controlled trial

31 March 2020

1 reference

https://api.fatcat.wiki/v0/release/l2s3rf4ownemtk5xvgh7l24kd4

31 March 2020

Identifiers

1 reference

mapped directly with Wikidata item

30 July 2022

based on heuristic

Fatcat ID

release_l2s3rf4ownemtk5xvgh7l24kd4

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/l2s3rf4ownemtk5xvgh7l24kd4

mapped directly with Wikidata item

30 July 2022

based on heuristic

OpenCitations bibliographic resource ID

1001496

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

1001496

PubMed publication ID

1 reference

https://api.fatcat.wiki/v0/release/l2s3rf4ownemtk5xvgh7l24kd4