The dark side of C5a in sepsis (Q28252425)

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scientific article (publication date: February 2004)

Language	Label	Description	Also known as
English	The dark side of C5a in sepsis	scientific article (publication date: February 2004)

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scholarly article

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Europe PubMed Central

The dark side of C5a in sepsis (English)

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author name string

Peter A Ward

1

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language of work or name

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publication date

February 2004

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Nature Reviews Immunology

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4

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133-42

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The chemotactic receptor for human C5a anaphylatoxin

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https://api.crossref.org/works/10.1038/NRI1269

21 April 2017

Residues 21-30 within the extracellular N-terminal region of the C5a receptor represent a binding domain for the C5a anaphylatoxin

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https://api.crossref.org/works/10.1038/NRI1269

21 April 2017

High mobility group 1 protein (HMG-1) stimulates proinflammatory cytokine synthesis in human monocytes

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21 April 2017

HMG-1 as a late mediator of endotoxin lethality in mice

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21 April 2017

Mitogen-activated Protein Kinase Activation Requires Two Signal Inputs from the Human Anaphylatoxin C5a Receptor

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21 April 2017

Efficacy and safety of recombinant human activated protein C for severe sepsis

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21 April 2017

2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference

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21 April 2017

Definitions for sepsis and organ failure.

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31 March 2020

Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/Society of Critical Care Medicine

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31 March 2020

Association between tumour necrosis factor in serum and fatal outcome in patients with meningococcal disease

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https://api.crossref.org/works/10.1038%2FNRI1269

31 March 2020

Circulating interleukin-1 and tumor necrosis factor in septic shock and experimental endotoxin fever

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https://api.crossref.org/works/10.1038%2FNRI1269

31 March 2020

Serum Cytokine Levels in Human Septic Shock

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31 March 2020

Clinical trials of immunomodulatory therapies in severe sepsis and septic shock

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https://api.crossref.org/works/10.1038%2FNRI1269

31 March 2020

Novel strategies for the treatment of sepsis

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https://api.crossref.org/works/10.1038%2FNRI1269

31 March 2020

Anti-c5a ameliorates coagulation/fibrinolytic protein changes in a rat model of sepsis

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https://api.crossref.org/works/10.1038%2FNRI1269

31 March 2020

Protective effects of anti-C5a in sepsis-induced thymocyte apoptosis

1 reference

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31 March 2020

Regulation by complement C3a and C5a anaphylatoxins of cytokine production in human umbilical vein endothelial cells

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31 March 2020

Complement c3a and c5a induce different signal transduction cascades in endothelial cells

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https://api.crossref.org/works/10.1038%2FNRI1269

31 March 2020

Expression and function of the C5a receptor in rat alveolar epithelial cells

1 reference

https://api.crossref.org/works/10.1038%2FNRI1269

31 March 2020

Expression and function of C5a receptor in mouse microvascular endothelial cells

1 reference

https://api.crossref.org/works/10.1038%2FNRI1269

31 March 2020

In vitro Responses of Human Asthmatic Airway and Pulmonary Vascular Smooth Muscle

1 reference

https://api.crossref.org/works/10.1038%2FNRI1269

31 March 2020

Phagocytosis of Legionella pneumophila is mediated by human monocyte complement receptors

1 reference

https://api.crossref.org/works/10.1038%2FNRI1269

31 March 2020

Activation of the fifth component of human complement, C5, without cleavage, by methionine oxidizing agents

1 reference

https://api.crossref.org/works/10.1038%2FNRI1269

31 March 2020

The cobra complement system: I. The alternative pathway of activation

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https://api.crossref.org/works/10.1038%2FNRI1269

31 March 2020

Studies of group B streptococcal infection in mice deficient in complement component C3 or C4 demonstrate an essential role for complement in both innate and acquired immunity

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https://api.crossref.org/works/10.1038%2FNRI1269

31 March 2020

Immunoglobulin G-mediated inflammatory responses develop normally in complement-deficient mice

1 reference

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31 March 2020

Modulation of immune complex-induced inflammation in vivo by the coordinate expression of activation and inhibitory Fc receptors.

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31 March 2020

The role of complement in inflammation and adaptive immunity

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31 March 2020

Role for the alternative complement pathway in ischemia/reperfusion injury

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31 March 2020

Complement deficiencies

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31 March 2020

Complement and renal disease.

1 reference

https://api.crossref.org/works/10.1038%2FNRI1269

31 March 2020

Chemotactic and anaphylatoxic fragment cleaved from the fifth component of guinea pig complement

1 reference

https://api.crossref.org/works/10.1038%2FNRI1269

31 March 2020

Demonstration of specific C5a receptor on intact human polymorphonuclear leukocytes

1 reference

https://api.crossref.org/works/10.1038%2FNRI1269

31 March 2020

Structure-function relationships of human C5a and C5aR.

1 reference

https://api.crossref.org/works/10.1038%2FNRI1269

31 March 2020

Two-site binding of C5a by its receptor: an alternative binding paradigm for G protein-coupled receptors

1 reference

https://api.crossref.org/works/10.1038%2FNRI1269

31 March 2020

Site-directed mutagenesis of conserved charged residues in the helical region of the human C5a receptor. Arg2O6 determines high-affinity binding sites of C5a receptor

1 reference

https://api.crossref.org/works/10.1038%2FNRI1269

31 March 2020

Epitope mapping of a C5a neutralizing mAb using a combined approach of phage display, synthetic peptides and site-directed mutagenesis

1 reference

https://api.crossref.org/works/10.1038%2FNRI1269

31 March 2020

Role of the second extracellular loop of human C3a receptor in agonist binding and receptor function

1 reference

https://api.crossref.org/works/10.1038%2FNRI1269

31 March 2020

Complement-induced impairment of innate immunity during sepsis

1 reference

https://api.crossref.org/works/10.1038%2FNRI1269

31 March 2020

Arachidonic acid triggers an oxidative burst in leukocytes

1 reference

https://api.crossref.org/works/10.1038%2FNRI1269

31 March 2020

The anaphylatoxins C3a and C5a are vasodilators in the canine coronary vasculaturein vitro andin vivo

1 reference

https://api.crossref.org/works/10.1038%2FNRI1269

31 March 2020

Oxygen radicals mediate endothelial cell damage by complement-stimulated granulocytes. An in vitro model of immune vascular damage

1 reference

https://api.crossref.org/works/10.1038%2FNRI1269

31 March 2020

C5a delays apoptosis of human neutrophils by a phosphatidylinositol 3-kinase-signaling pathway

1 reference

https://api.crossref.org/works/10.1038%2FNRI1269

31 March 2020

C3a and C5a enhance granulocyte adhesion to endothelial and epithelial cell monolayers: epithelial and endothelial priming is required for C3a-induced eosinophil adhesion

1 reference

https://api.crossref.org/works/10.1038%2FNRI1269

31 March 2020

Immunocomplexes stimulate different signalling events to chemoattractants in the neutrophil and regulate L-selectin and beta 2-integrin expression differently

1 reference

https://api.crossref.org/works/10.1038%2FNRI1269

31 March 2020

C5a-induced expression of P-selectin in endothelial cells

1 reference

https://api.crossref.org/works/10.1038%2FNRI1269

31 March 2020

Inhibition of interleukin-6 synthesis in an animal model of septic shock by anti-C5a monoclonal antibodies

1 reference

https://api.crossref.org/works/10.1038%2FNRI1269

31 March 2020

Systemic and lung physiological changes in rats after intravascular activation of complement

1 reference

https://api.crossref.org/works/10.1038%2FNRI1269

31 March 2020

Complement levels in septic primates treated with anti-C5a antibodies

1 reference

https://api.crossref.org/works/10.1038%2FNRI1269

31 March 2020

Effects of anti-C5a antibodies on the adult respiratory distress syndrome in septic primates

1 reference

https://api.crossref.org/works/10.1038%2FNRI1269

31 March 2020

Protective effects of C5a blockade in sepsis

1 reference

https://api.crossref.org/works/10.1038%2FNRI1269

31 March 2020

Role of C5a in multiorgan failure during sepsis

1 reference

https://api.crossref.org/works/10.1038%2FNRI1269

31 March 2020

Complement activation and endotoxin levels in systemic meningococcal disease

1 reference

https://api.crossref.org/works/10.1038%2FNRI1269

31 March 2020

Complement activation and polymorphonuclear neutrophil leukocyte elastase in sepsis. Correlation with severity of disease.

1 reference

https://api.crossref.org/works/10.1038%2FNRI1269

31 March 2020

Complement C5a in the sepsis syndrome--too much of a good thing?

1 reference

https://api.crossref.org/works/10.1038%2FNRI1269

31 March 2020

Neutrophil C5a receptor and the outcome in a rat model of sepsis

1 reference

https://api.crossref.org/works/10.1038%2FNRI1269

31 March 2020

Alteration of chemoattractant receptor expression regulates human neutrophil chemotaxis in vivo

1 reference

https://api.crossref.org/works/10.1038%2FNRI1269

31 March 2020

Regulation by C5a of neutrophil activation during sepsis

1 reference

https://api.crossref.org/works/10.1038%2FNRI1269

31 March 2020

C5 chemotactic fragment induces leukocyte production of tissue factor activity: a link between complement and coagulation

1 reference

https://api.crossref.org/works/10.1038%2FNRI1269

31 March 2020

The role of the endothelium in severe sepsis and multiple organ dysfunction syndrome

1 reference

https://api.crossref.org/works/10.1038%2FNRI1269

31 March 2020

Sepsis-induced apoptosis causes progressive profound depletion of B and CD4+ T lymphocytes in humans

1 reference

https://api.crossref.org/works/10.1038%2FNRI1269

31 March 2020

Caspase inhibitors improve survival in sepsis: a critical role of the lymphocyte

1 reference

https://api.crossref.org/works/10.1038%2FNRI1269

31 March 2020

C5a receptor and thymocyte apoptosis in sepsis

1 reference

https://api.crossref.org/works/10.1038%2FNRI1269

31 March 2020

Increased C5a receptor expression in sepsis

1 reference

https://api.crossref.org/works/10.1038%2FNRI1269

31 March 2020

Protective effects of IL-6 blockade in sepsis are linked to reduced C5a receptor expression

1 reference

https://api.crossref.org/works/10.1038%2FNRI1269

31 March 2020

The acute phase protein response in patients receiving subcutaneous IL-6.

1 reference

https://api.crossref.org/works/10.1038%2FNRI1269

31 March 2020

Protection of innate immunity by C5aR antagonist in septic mice

1 reference

https://api.crossref.org/works/10.1038%2FNRI1269

31 March 2020

Effects of a new C5a receptor antagonist on C5a- and endotoxin-induced neutropenia in the rat.

1 reference

https://api.crossref.org/works/10.1038%2FNRI1269

31 March 2020

Regulation of DNA-dependent activities by the functional motifs of the high-mobility-group chromosomal proteins

1 reference

https://api.crossref.org/works/10.1038%2FNRI1269

31 March 2020

Inflammation-promoting activity of HMGB1 on human microvascular endothelial cells

1 reference

https://api.crossref.org/works/10.1038%2FNRI1269

31 March 2020

Macrophage migration inhibitory factor (MIF): Its potential role in tumor growth and tumor-associated angiogenesis

1 reference

https://api.crossref.org/works/10.1038%2FNRI1269

31 March 2020

Macrophage migration inhibitory factor is a critical mediator of systemic inflammatory response syndrome

1 reference

https://api.crossref.org/works/10.1038%2FNRI1269

31 March 2020

Protection from septic shock by neutralization of macrophage migration inhibitory factor

1 reference

https://api.crossref.org/works/10.1038%2FNRI1269

31 March 2020

Passive immunization against cachectin/tumor necrosis factor protects mice from lethal effect of endotoxin

1 reference

https://api.crossref.org/works/10.1038%2FNRI1269

31 March 2020

Anti-cachectin/TNF monoclonal antibodies prevent septic shock during lethal bacteraemia

1 reference

https://api.crossref.org/works/10.1038%2FNRI1269

31 March 2020

Endotoxin, TNF-alpha, interleukin-6 and parameters of the cellular immune system in patients with intraabdominal sepsis

1 reference

https://api.crossref.org/works/10.1038%2FNRI1269

31 March 2020

Cleavage of the fifth component of complement and generation of a functionally active C5b6-like complex by human leukocyte elastase

1 reference

https://api.crossref.org/works/10.1038%2FNRI1269

31 March 2020

Generation of C5a by phagocytic cells

1 reference

https://api.crossref.org/works/10.1038%2FNRI1269

31 March 2020

G alpha 16, a G protein alpha subunit specifically expressed in hematopoietic cells

1 reference

https://api.crossref.org/works/10.1038%2FNRI1269

31 March 2020

Pertussis toxin-sensitive activation of phospholipase C by the C5a and fMet-Leu-Phe receptors

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https://api.crossref.org/works/10.1038%2FNRI1269

31 March 2020

Anti-tumor necrosis factor therapy in sepsis: update on clinical trials and lessons learned

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https://api.crossref.org/works/10.1038%2FNRI1269

31 March 2020

Adjunctive therapy in sepsis: a critical analysis of the clinical trial programme

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31 March 2020

C1 inhibitor prevents endotoxin shock via a direct interaction with lipopolysaccharide

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31 March 2020

Confirmatory interleukin-1 receptor antagonist trial in severe sepsis: a phase III, randomized, double-blind, placebo-controlled, multicenter trial. The Interleukin-1 Receptor Antagonist Sepsis Investigator Group

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31 March 2020

Confirmatory platelet-activating factor receptor antagonist trial in patients with severe gram-negative bacterial sepsis: a phase III, randomized, double-blind, placebo-controlled, multicenter trial. BN 52021 Sepsis Investigator Group

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31 March 2020

A multi-centre, double-blind, placebo-controlled study of liposomal prostaglandin E1 (TLC C-53) in patients with acute respiratory distress syndrome

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31 March 2020

A double-blind, prospective, randomized trial of ketoconazole, a thromboxane synthetase inhibitor, in the prophylaxis of the adult respiratory distress syndrome.

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31 March 2020

Prolonged inhibition of nitric oxide synthesis in severe septic shock: a clinical study

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31 March 2020

Caring for the critically ill patient. High-dose antithrombin III in severe sepsis: a randomized controlled trial

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31 March 2020

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