Loss of mTOR-dependent macroautophagy causes autistic-like synaptic pruning deficits (Q28246677)

Zhenyu Yue

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Alexander Sosunov

Alexander Sosunov

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Kathryn Gudsnuk

Kathryn Gudsnuk

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Guomei Tang

Guomei Tang

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Candace Castagna

Candace Castagna

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Mark S Sonders

Mark S Sonders

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author name string

Marisa L Cotrina

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Gorazd Rosoklija

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Ellen Kanter

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Ai Yamamoto

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Bradley S Peterson

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Andrew J Dwork

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James Goldman

Multiple autism-linked genes mediate synapse elimination via proteasomal degradation of a synaptic scaffold PSD-95

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language of work or name

English

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publication date

3 September 2014

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1131-43

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cites work

1 reference

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Common circuit defect of excitatory-inhibitory balance in mouse models of autism

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mTOR signaling: at the crossroads of plasticity, memory and disease

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Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice

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Loss of autophagy in the central nervous system causes neurodegeneration in mice

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Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice

20 March 2017

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20 March 2017

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AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

20 March 2017

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Disruption of neuronal autophagy by infected microglia results in neurodegeneration

20 March 2017

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Essential role for autophagy protein Atg7 in the maintenance of axonal homeostasis and the prevention of axonal degeneration

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Synaptic pruning by microglia is necessary for normal brain development

7 April 2017

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Transcriptomic analysis of autistic brain reveals convergent molecular pathology

7 April 2017

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Dendritic spine pathology in neuropsychiatric disorders

7 April 2017

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Dysfunction in GABA signalling mediates autism-like stereotypies and Rett syndrome phenotypes

7 April 2017

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Synaptic plasticity and memory: an evaluation of the hypothesis

7 April 2017

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A synaptic trek to autism

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Astrocytes mediate synapse elimination through MEGF10 and MERTK pathways

7 April 2017

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Identification of small exonic CNV from whole-exome sequence data and application to autism spectrum disorder

29 September 2017

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Distinct roles for somatically and dendritically synthesized brain-derived neurotrophic factor in morphogenesis of dendritic spines

29 September 2017

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Temporal and mosaic Tsc1 deletion in the developing thalamus disrupts thalamocortical circuitry, neural function, and behavior

29 September 2017

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Mitochondrial abnormalities in temporal lobe of autistic brain

29 September 2017

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Exaggerated translation causes synaptic and behavioural aberrations associated with autism

29 September 2017

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Rapamycin reverses impaired social interaction in mouse models of tuberous sclerosis complex

29 September 2017

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Fractionation of social brain circuits in autism spectrum disorders

29 September 2017

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29 September 2017

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29 September 2017

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Synaptic dysfunction in neurodevelopmental disorders associated with autism and intellectual disabilities

29 September 2017

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Dysregulation of mTOR signaling in neuropsychiatric disorders: therapeutic implications.

29 September 2017

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mTOR kinase inhibition causes feedback-dependent biphasic regulation of AKT signaling

29 September 2017

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GABAergic interneuron development and function is modulated by the Tsc1 gene

29 September 2017

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Impaired social interactions and motor learning skills in tuberous sclerosis complex model mice expressing a dominant/negative form of tuberin

29 September 2017

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Extraordinary neoteny of synaptic spines in the human prefrontal cortex.

29 September 2017

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Functional differentiation of posterior superior temporal sulcus in autism: a functional connectivity magnetic resonance imaging study.

29 September 2017

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Deconstruction for reconstruction: the role of proteolysis in neural plasticity and disease

29 September 2017

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Rapamycin for treating Tuberous sclerosis and Autism spectrum disorders

29 September 2017

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Gestational immune activation and Tsc2 haploinsufficiency cooperate to disrupt fetal survival and may perturb social behavior in adult mice

29 September 2017

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Persistent synapse loss induced by repetitive LTD in developing rat hippocampal neurons

29 September 2017

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Fragile X mental retardation protein is required for synapse elimination by the activity-dependent transcription factor MEF2.

29 September 2017

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Cargo recognition failure is responsible for inefficient autophagy in Huntington's disease

29 September 2017

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A coordinated local translational control point at the synapse involving relief from silencing and MOV10 degradation

29 September 2017

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Autophagy promotes synapse development in Drosophila

29 September 2017

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Immune transcriptome alterations in the temporal cortex of subjects with autism.

29 September 2017

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Pyramidal neurons: dendritic structure and synaptic integration

29 September 2017

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Cognitive deficits in Tsc1+/- mice in the absence of cerebral lesions and seizures.

29 September 2017

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The superior temporal sulcus performs a common function for social and speech perception: implications for the emergence of autism

29 September 2017

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Social concepts are represented in the superior anterior temporal cortex

29 September 2017

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Long-term sensory deprivation prevents dendritic spine loss in primary somatosensory cortex

29 September 2017

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29 September 2017

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Mechanisms of synapse assembly and disassembly

29 September 2017

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Structural changes accompanying memory storage

29 September 2017

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29 September 2017

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29 September 2017

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Neuronal stimulation induces autophagy in hippocampal neurons that is involved in AMPA receptor degradation after chemical long-term depression.

2 June 2018

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Regulation of presynaptic neurotransmission by macroautophagy

27 November 2018

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Increased dendritic spine densities on cortical projection neurons in autism spectrum disorders

27 November 2018

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Presynaptic terminals independently regulate synaptic clustering and autophagy of GABAA receptors in Caenorhabditis elegans.

27 November 2018

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Theoretical neuroanatomy: relating anatomical and functional connectivity in graphs and cortical connection matrices

27 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25155956

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Elimination of synapses in the developing nervous system

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25155956

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.NEURON.2014.07.040

1 reference

1 reference

1 reference

PubMed publication ID

25155956

1 reference