Orchestrating ontogenesis: variations on a theme by sonic hedgehog (Q36626603)

15 August 2017

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title

Orchestrating ontogenesis: variations on a theme by sonic hedgehog (English)

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15 August 2017

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15 August 2017

Marysia Placzek

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1 November 2006

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15 August 2017

published in

Nature Reviews Genetics

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15 August 2017

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15 August 2017

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15 August 2017

page(s)

841-850

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Hedgehog signaling in animal development: paradigms and principles

15 August 2017

cites work

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Inactivation of dispatched 1 by the chameleon mutation disrupts Hedgehog signalling in the zebrafish embryo

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Shifted, the Drosophila ortholog of Wnt inhibitory factor-1, controls the distribution and movement of Hedgehog

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The Drosophila ortholog of the human Wnt inhibitor factor Shifted controls the diffusion of lipid-modified Hedgehog

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The ihog cell-surface proteins bind Hedgehog and mediate pathway activation

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Cdo functions at multiple points in the Sonic Hedgehog pathway, and Cdo-deficient mice accurately model human holoprosencephaly

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Role of the Drosophila patched gene in positional signalling

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smoothened encodes a receptor-like serpentine protein required for hedgehog signalling

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The Drosophila smoothened gene encodes a seven-pass membrane protein, a putative receptor for the hedgehog signal

31 March 2020

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The tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehog

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Transcriptional activation of hedgehog target genes in Drosophila is mediated directly by the cubitus interruptus protein, a member of the GLI family of zinc finger DNA-binding proteins.

31 March 2020

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All mouse ventral spinal cord patterning by hedgehog is Gli dependent and involves an activator function of Gli3

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Hedgehog-regulated processing of Gli3 produces an anterior/posterior repressor gradient in the developing vertebrate limb

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Sonic hedgehog signaling regulates Gli2 transcriptional activity by suppressing its processing and degradation

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The specification of neuronal identity by graded Sonic Hedgehog signalling.

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Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity

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A functionally conserved homolog of the Drosophila segment polarity gene hh is expressed in tissues with polarizing activity in zebrafish embryos

31 March 2020

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Floor plate and motor neuron induction by vhh-1, a vertebrate homolog of hedgehog expressed by the notochord

31 March 2020

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The whereabouts of a morphogen: direct evidence for short- and graded long-range activity of hedgehog signaling peptides

31 March 2020

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Opponent activities of Shh and BMP signaling during floor plate induction in vivo

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Sonic hedgehog control of size and shape in midbrain pattern formation

31 March 2020

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The seven-transmembrane receptor smoothened cell-autonomously induces multiple ventral cell types

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A hedgehog-insensitive form of patched provides evidence for direct long-range morphogen activity of sonic hedgehog in the neural tube.

31 March 2020

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A direct requirement for Hedgehog signaling for normal specification of all ventral progenitor domains in the presumptive mammalian spinal cord

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A homeodomain protein code specifies progenitor cell identity and neuronal fate in the ventral neural tube

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Specification of ventral neuron types is mediated by an antagonistic interaction between Shh and Gli3

31 March 2020

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Dorsal-ventral patterning of the spinal cord requires Gli3 transcriptional repressor activity

31 March 2020

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Transduction of graded Hedgehog signaling by a combination of Gli2 and Gli3 activator functions in the developing spinal cord

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A gradient of Gli activity mediates graded Sonic Hedgehog signaling in the neural tube

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Sonic hedgehog regulates adult neural progenitor proliferation in vitro and in vivo

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Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function

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Sonic hedgehog regulates proliferation and inhibits differentiation of CNS precursor cells.

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Growth and pattern of the mammalian neural tube are governed by partially overlapping feedback activities of the hedgehog antagonists patched 1 and Hhip1

31 March 2020

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The Sonic hedgehog pathway independently controls the patterning, proliferation and survival of neuroepithelial cells by regulating Gli activity

31 March 2020

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Shh directs cell-cycle exit by activating p57Kip2 in the zebrafish retina

31 March 2020

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Hedgehog signalling and the specification of muscle cell identity in the zebrafish embryo

31 March 2020

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Multiple muscle cell identities induced by distinct levels and timing of hedgehog activity in the zebrafish embryo

31 March 2020

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Sonic hedgehog mediates the polarizing activity of the ZPA

31 March 2020

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Dynamic changes in the response of cells to positive hedgehog signaling during mouse limb patterning

31 March 2020

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Evidence for an expansion-based temporal Shh gradient in specifying vertebrate digit identities

31 March 2020

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Dual roles for patched in sequestering and transducing Hedgehog

31 March 2020

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Patterning Systems—From One End of the Limb to the Other

31 March 2020

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FGF-4 and BMP-2 have opposite effects on limb growth.

31 March 2020

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The limb bud Shh-Fgf feedback loop is terminated by expansion of former ZPA cells.

31 March 2020

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The B-cell maturation factor Blimp-1 specifies vertebrate slow-twitch muscle fiber identity in response to Hedgehog signaling

31 March 2020

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Spatial and temporal regulation of ventral spinal cord precursor specification by Hedgehog signaling

31 March 2020

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The basic helix-loop-helix factor olig2 is essential for the development of motoneuron and oligodendrocyte lineages.

31 March 2020

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Olig2 and Ngn2 function in opposition to modulate gene expression in motor neuron progenitor cells

31 March 2020

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The bHLH transcription factor Olig2 promotes oligodendrocyte differentiation in collaboration with Nkx2.2.

31 March 2020

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Localized hedgehog activity controls spatial limits of wingless transcription in the Drosophila embryo

31 March 2020

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Localized expression of sloppy paired protein maintains the polarity of Drosophila parasegments

31 March 2020

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Drosophila T box proteins break the symmetry of hedgehog-dependent activation of wingless.

31 March 2020

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Compartments and their boundaries in vertebrate brain development

31 March 2020

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Hedgehog signaling from the ZLI regulates diencephalic regional identity

31 March 2020

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Graded changes in dose of a Xenopus activin A homologue elicit stepwise transitions in embryonic cell fate

31 March 2020

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Activin has direct long-range signalling activity and can form a concentration gradient by diffusion

31 March 2020

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The zebrafish Nodal signal Squint functions as a morphogen

31 March 2020

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Many ways to make a gradient

31 March 2020

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Endocytosis controls spreading and effective signaling range of Fgf8 protein

31 March 2020

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Sprouty, an intracellular inhibitor of Ras signaling.

31 March 2020

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naked cuticle encodes an inducible antagonist of Wnt signalling

31 March 2020

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Orientation of asymmetric stem cell division by the APC tumor suppressor and centrosome.

31 March 2020

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A Role for the Roof Plate and Its Resident TGFβ-Related Proteins in Neuronal Patterning in the Dorsal Spinal Cord

31 March 2020

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FGF2-induced chromatin remodeling regulates CNTF-mediated gene expression and astrocyte differentiation

31 March 2020

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Wnt signaling inhibitors regulate the transcriptional response to morphogenetic Shh-Gli signaling in the neural tube

31 March 2020

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Roadkill attenuates Hedgehog responses through degradation of Cubitus interruptus

31 March 2020

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A hedgehog-induced BTB protein modulates hedgehog signaling by degrading Ci/Gli transcription factor.

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRG1969

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15 August 2017

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