Mammalian proapoptotic factor ChaC1 and its homologues function as γ-glutamyl cyclotransferases acting specifically on glutathione (Q27940255)

23070364

1 December 2016

title

Mammalian proapoptotic factor ChaC1 and its homologues function as γ-glutamyl cyclotransferases acting specifically on glutathione (English)

1 reference

PubMed

glutathione specific gamma-glutamylcyclotransferase activity

1 December 2016

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1 reference

Gene Ontology release 2020-05-02

Gene Ontology ID

GO:0061928

Gamma-glutamylcyclotransferase YER163C

1 reference

GOA release 2020-03-11

1 reference

Akhilesh Kumar

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Shweta Tikoo

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Shuvadeep Maity

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Shantanu Sengupta

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Sagar Sengupta

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Amandeep Kaur

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Anand Kumar Bachhawat

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language of work or name

English

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publication date

December 2012

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1 reference

Glutathione degradation by the alternative pathway (DUG pathway) in Saccharomyces cerevisiae is initiated by (Dug2p-Dug3p)2 complex, a novel glutamine amidotransferase (GATase) enzyme acting on glutathione

1 December 2016

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1095-101

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cites work

1 reference

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OXP1/YKL215c encodes an ATP-dependent 5-oxoprolinase in Saccharomyces cerevisiae: functional characterization, domain structure and identification of actin-like ATP-binding motifs in eukaryotic 5-oxoprolinases

20 March 2017

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Identification and characterization of gamma-glutamylamine cyclotransferase, an enzyme responsible for gamma-glutamyl-epsilon-lysine catabolism

20 March 2017

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Dug1p Is a Cys-Gly peptidase of the gamma-glutamyl cycle of Saccharomyces cerevisiae and represents a novel family of Cys-Gly peptidases

20 March 2017

1 reference

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CHAC1/MGC4504 is a novel proapoptotic component of the unfolded protein response, downstream of the ATF4-ATF3-CHOP cascade

20 March 2017

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The identification and structural characterization of C7orf24 as gamma-glutamyl cyclotransferase. An essential enzyme in the gamma-glutamyl cycle

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Roles of CHOP/GADD153 in endoplasmic reticulum stress

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CHOP induces death by promoting protein synthesis and oxidation in the stressed endoplasmic reticulum

20 March 2017

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Gadd153 sensitizes cells to endoplasmic reticulum stress by down-regulating Bcl2 and perturbing the cellular redox state

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Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress

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ER stress triggers apoptosis by activating BH3-only protein Bim

7 April 2017

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Elevated mRNA expression of CHAC1 splicing variants is associated with poor outcome for breast and ovarian cancer patients

7 April 2017

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Calcium/calmodulin-dependent protein kinase II links ER stress with Fas and mitochondrial apoptosis pathways.

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Glutathione depletion is necessary for apoptosis in lymphoid cells independent of reactive oxygen species formation

29 September 2017

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SLCO/OATP-like transport of glutathione in FasL-induced apoptosis: glutathione efflux is coupled to an organic anion exchange and is necessary for the progression of the execution phase of apoptosis.

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Crossref

https://api.crossref.org/works/10.1038%2FEMBOR.2012.156

Assay for quantitative determination of glutathione and glutathione disulfide levels using enzymatic recycling method

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23070364

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/EMBOR.2012.156

1 reference

1 reference

1 reference

23070364

1 reference