Membrane-bound Ubx2 recruits Cdc48 to ubiquitin ligases and their substrates to ensure efficient ER-associated protein degradation (Q27935765)

1 December 2016

title

Membrane-bound Ubx2 recruits Cdc48 to ubiquitin ligases and their substrates to ensure efficient ER-associated protein degradation (English)

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PubMed

PubMed publication ID

16179952

VCP-NPL4-UFD1 AAA ATPase complex

1 December 2016

main subject

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Gene Ontology release 2020-05-02

Gene Ontology ID

GO:0034098

AAA family ATPase CDC48 YDL126C

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E3 ubiquitin-protein ligase SSM4 YIL030C

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Derlin YBR201W

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Nuclear protein localization protein 4 YBR170C

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Ubx2p YML013W

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E3 ubiquitin-protein ligase HRD1 YOL013C

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Polyubiquitin-binding protein UFD1 YGR048W

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Hrd1p/Der3p is a membrane-anchored ubiquitin ligase required for ER-associated degradation.

author name string

Christian Schuberth

series ordinal

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Alexander Buchberger

series ordinal

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language of work or name

English

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publication date

October 2005

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1 reference

PubMed publication ID

1 December 2016

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999-1006

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cites work

1 reference

Membrane topology and function of Der3/Hrd1p as a ubiquitin-protein ligase (E3) involved in endoplasmic reticulum degradation

20 April 2017

1 reference

A conserved ubiquitin ligase of the nuclear envelope/endoplasmic reticulum that functions in both ER-associated and Matalpha2 repressor degradation

20 April 2017

1 reference

The AAA ATPase Cdc48/p97 and its partners transport proteins from the ER into the cytosol

20 April 2017

1 reference

Protein dislocation from the ER requires polyubiquitination and the AAA-ATPase Cdc48.

20 April 2017

1 reference

AAA-ATPase p97/Cdc48p, a cytosolic chaperone required for endoplasmic reticulum-associated protein degradation

20 April 2017

1 reference

Der1p, a protein required for degradation of malfolded soluble proteins of the endoplasmic reticulum: topology and Der1-like proteins

20 April 2017

1 reference

A membrane protein required for dislocation of misfolded proteins from the ER

20 April 2017

1 reference

A membrane protein complex mediates retro-translocation from the ER lumen into the cytosol

20 April 2017

1 reference

A proteolytic pathway that recognizes ubiquitin as a degradation signal

20 April 2017

1 reference

Mobilization of processed, membrane-tethered SPT23 transcription factor by CDC48(UFD1/NPL4), a ubiquitin-selective chaperone

20 April 2017

1 reference

The UBX domain: a widespread ubiquitin-like module

20 April 2017

1 reference

Binding of Cdc48p to a ubiquitin-related UBX domain from novel yeast proteins involved in intracellular proteolysis and sporulation.

20 April 2017

1 reference

Shp1 and Ubx2 are adaptors of Cdc48 involved in ubiquitin-dependent protein degradation

20 April 2017

1 reference

VCIP135 acts as a deubiquitinating enzyme during p97-p47-mediated reassembly of mitotic Golgi fragments

20 April 2017

1 reference

A complex of mammalian ufd1 and npl4 links the AAA-ATPase, p97, to ubiquitin and nuclear transport pathways

20 April 2017

1 reference

Misfolded proteins are sorted by a sequential checkpoint mechanism of ER quality control

20 April 2017

1 reference

PCR-synthesis of marker cassettes with long flanking homology regions for gene disruptions in S. cerevisiae

20 April 2017

1 reference

Epitope tagging of yeast genes using a PCR-based strategy: more tags and improved practical routines

20 April 2017

1 reference

ER-associated degradation in protein quality control and cellular regulation

20 April 2017

1 reference

For whom the bell tolls: protein quality control of the endoplasmic reticulum and the ubiquitin-proteasome connection

21 January 2018

1 reference

HRD4/NPL4 is required for the proteasomal processing of ubiquitinated ER proteins

21 January 2018

1 reference

Role of the ubiquitin-selective CDC48(UFD1/NPL4 )chaperone (segregase) in ERAD of OLE1 and other substrates

21 January 2018

1 reference

Machinery of protein folding and unfolding

21 January 2018

1 reference

From UBA to UBX: new words in the ubiquitin vocabulary.

21 January 2018

1 reference

The Ubx2 and Ubx3 cofactors direct Cdc48 activity to proteolytic and nonproteolytic ubiquitin-dependent processes

21 January 2018

1 reference

RNA interference of valosin-containing protein (VCP/p97) reveals multiple cellular roles linked to ubiquitin/proteasome-dependent proteolysis

21 January 2018

1 reference

ER degradation of a misfolded luminal protein by the cytosolic ubiquitin-proteasome pathway

21 January 2018

1 reference

Role of 26S proteasome and HRD genes in the degradation of 3-hydroxy-3-methylglutaryl-CoA reductase, an integral endoplasmic reticulum membrane protein

21 January 2018

1 reference

The yeast polyubiquitin gene is essential for resistance to high temperatures, starvation, and other stresses

21 January 2018

1 reference

p97, a protein coping with multiple identities

21 January 2018

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Cdc48p interacts with Ufd3p, a WD repeat protein required for ubiquitin-mediated proteolysis in Saccharomyces cerevisiae.

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