HRD4/NPL4 is required for the proteasomal processing of ubiquitinated ER proteins (Q27939971)

11739805

1 December 2016

title

HRD4/NPL4 is required for the proteasomal processing of ubiquitinated ER proteins (English)

1 reference

11739805

AAA family ATPase CDC48 YDL126C

1 December 2016

main subject

1 reference

Polyubiquitin-binding protein UFD1 YGR048W

GOA release 2020-03-11

1 reference

Nuclear protein localization protein 4 YBR170C

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

protein ubiquitination

1 reference

N W Bays

0 references

S K Wilhovsky

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A Goradia

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K Hodgkiss-Harlow

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R Y Hampton

Molecular Biology of the Cell

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language of work or name

English

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publication date

December 2001

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published in

1 reference

The conserved npl4 protein complex mediates proteasome-dependent membrane-bound transcription factor activation

1 December 2016

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4114-28

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cites work

1 reference

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Valosin-containing protein is a multi-ubiquitin chain-targeting factor required in ubiquitin-proteasome degradation

20 March 2017

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Hrd1p/Der3p is a membrane-anchored ubiquitin ligase required for ER-associated degradation.

20 March 2017

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Activation of a membrane-bound transcription factor by regulated ubiquitin/proteasome-dependent processing.

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A complex of mammalian ufd1 and npl4 links the AAA-ATPase, p97, to ubiquitin and nuclear transport pathways

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Der3p/Hrd1p is required for endoplasmic reticulum-associated degradation of misfolded lumenal and integral membrane proteins

20 March 2017

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20 March 2017

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ER degradation of a misfolded luminal protein by the cytosolic ubiquitin-proteasome pathway

20 March 2017

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20 March 2017

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Multiple ubiquitin-conjugating enzymes participate in the in vivo degradation of the yeast MAT alpha 2 repressor

20 March 2017

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20 March 2017

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The yeast SEN3 gene encodes a regulatory subunit of the 26S proteasome complex required for ubiquitin-dependent protein degradation in vivo

20 March 2017

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Membrane fusion and the cell cycle: Cdc48p participates in the fusion of ER membranes

20 March 2017

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20 March 2017

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The OLE1 gene of Saccharomyces cerevisiae encodes the delta 9 fatty acid desaturase and can be functionally replaced by the rat stearoyl-CoA desaturase gene.

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=60780

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20 March 2017

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20 March 2017

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Functional and genomic analyses reveal an essential coordination between the unfolded protein response and ER-associated degradation

20 March 2017

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A temperature-sensitive NUP116 null mutant forms a nuclear envelope seal over the yeast nuclear pore complex thereby blocking nucleocytoplasmic traffic

20 March 2017

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Endoplasmic reticulum degradation requires lumen to cytosol signaling. Transmembrane control of Hrd1p by Hrd3p.

7 April 2017

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The unfolded protein response regulates multiple aspects of secretory and membrane protein biogenesis and endoplasmic reticulum quality control

29 September 2017

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Assembly and preferential localization of Nup116p on the cytoplasmic face of the nuclear pore complex by interaction with Nup82p

29 September 2017

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HRD gene dependence of endoplasmic reticulum-associated degradation

29 September 2017

1 reference

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ER protein quality control and proteasome-mediated protein degradation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=60780

Posttranslational quality control: folding, refolding, and degrading proteins.

29 September 2017

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The AAA team: related ATPases with diverse functions

29 September 2017

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Multiubiquitin chain binding and protein degradation are mediated by distinct domains within the 26 S proteasome subunit Mcb1.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=60780

Ubiquitin-mediated regulation of 3-hydroxy-3-methylglutaryl-CoA reductase

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=60780

Role of 26S proteasome and HRD genes in the degradation of 3-hydroxy-3-methylglutaryl-CoA reductase, an integral endoplasmic reticulum membrane protein

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=60780

Nuclear transport defects and nuclear envelope alterations are associated with mutation of the Saccharomyces cerevisiae NPL4 gene

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=60780

Cdc48p interacts with Ufd3p, a WD repeat protein required for ubiquitin-mediated proteolysis in Saccharomyces cerevisiae.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=60780

The endoplasmic reticulum as a site of protein degradation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=60780

Regulated degradation of HMG-CoA reductase, an integral membrane protein of the endoplasmic reticulum, in yeast

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=60780

Quality control in the secretory pathway

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=60780

A role for unsaturated fatty acids in mitochondrial movement and inheritance

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=60780

The short-lived MAT alpha 2 transcriptional regulator is ubiquitinated in vivo

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=60780

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29 September 2017

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A highly conserved signal controls degradation of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase in eukaryotes

2 June 2018

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The promoter region of the yeast KAR2 (BiP) gene contains a regulatory domain that responds to the presence of unfolded proteins in the endoplasmic reticulum

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=60780

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2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=60780

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2 June 2018

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2 June 2018

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27 November 2018

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12 December 2020

Short-lived green fluorescent proteins for quantifying ubiquitin/proteasome-dependent proteolysis in living cells

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12 December 2020

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12 December 2020

Identifiers

DOI

10.1091/MBC.12.12.4114

1 reference

1 reference

1 reference

11739805

1 reference