Crystal structure of the GTPase-activating domain of human p120GAP and implications for the interaction with Ras (Q27734180)

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W Kabsch

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M R Ahmadian

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A Wittinghofer

The GTPase superfamily: conserved structure and molecular mechanism

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language of work or name

English

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publication date

12 December 1996

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published in

Nature

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volume

384

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issue

6609

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page(s)

591-6

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cites work

1 reference

7 January 2021

A cytoplasmic protein stimulates normal N-ras p21 GTPase, but does not affect oncogenic mutants

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7 January 2021

Structural differences in the minimal catalytic domains of the GTPase-activating proteins p120GAP and neurofibromin

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7 January 2021

Cloning of bovine GAP and its interaction with oncogenic ras p21.

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7 January 2021

Molecular cloning of two types of GAP complementary DNA from human placenta

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7 January 2021

Vascular system defects and neuronal apoptosis in mice lacking ras GTPase-activating protein

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7 January 2021

The neurofibromatosis type 1 gene encodes a protein related to GAP

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7 January 2021

Somatic mutations in the neurofibromatosis 1 gene in human tumors

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7 January 2021

Structures of active conformations of Gi alpha 1 and the mechanism of GTP hydrolysis

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7 January 2021

GTPase mechanism of Gproteins from the 1.7-A crystal structure of transducin alpha-GDP-AIF-4

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7 January 2021

Separate GTP binding and GTPase activating domains of a G alpha subunit

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7 January 2021

Formation of a Transition-State Analog of the Ras GTPase Reaction by Ras GDP, Tetrafluoroaluminate, and GTPase-Activating Proteins

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7 January 2021

p120 Ras GTPase-activating protein interacts with Ras-GTP through specific conserved residues

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7 January 2021

Identification of neurofibromin mutants that exhibit allele specificity or increased Ras affinity resulting in suppression of activated ras alleles

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7 January 2021

Functional significance of lysine 1423 of neurofibromin and characterization of a second site suppressor which rescues mutations at this residue and suppresses RAS2Val-19-activated phenotypes

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7 January 2021

A conserved region of c-Ha-Ras is required for efficient GTPase stimulation by GTPase activating protein but not neurofibromin

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7 January 2021

Refined crystal structure of the triphosphate conformation of H-ras p21 at 1.35 A resolution: implications for the mechanism of GTP hydrolysis

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7 January 2021

Inhibition of Ras/Raf interaction by anti-oncogenic mutants of neurofibromin, the neurofibromatosis type 1 (NF1) gene product, in cell-free systems

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7 January 2021

The 2.2 A crystal structure of the Ras-binding domain of the serine/threonine kinase c-Raf1 in complex with Rap1A and a GTP analogue

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7 January 2021

Mechanism of GTP hydrolysis by p21N-ras catalyzed by GAP: studies with a fluorescent GTP analogue

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7 January 2021

Is there a rate-limiting step before GTP cleavage by H-ras p21?

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7 January 2021

Automatic processing of rotation diffraction data from crystals of initially unknown symmetry and cell constants

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7 January 2021

Improved methods for building protein models in electron density maps and the location of errors in these models

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7 January 2021

Dictionary of protein secondary structure: pattern recognition of hydrogen-bonded and geometrical features

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7 January 2021

MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures

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7 January 2021