Does your gene need a background check? How genetic background impacts the analysis of mutations, genes, and evolution (Q27693280)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23453263%20AND%20SRC:MED&resulttype=core&format=json

24 February 2020

title

Does your gene need a background check? How genetic background impacts the analysis of mutations, genes, and evolution (English)

2 references

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24 February 2020

1 reference

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24 February 2020

1 reference

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24 February 2020

author name string

Christopher H Chandler

series ordinal

1 reference

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24 February 2020

publication date

28 February 2013

1 reference

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24 February 2020

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23453263%20AND%20SRC:MED&resulttype=core&format=json

24 February 2020

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23453263%20AND%20SRC:MED&resulttype=core&format=json

24 February 2020

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23453263%20AND%20SRC:MED&resulttype=core&format=json

24 February 2020

page(s)

358-366

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23453263%20AND%20SRC:MED&resulttype=core&format=json

Genomic analysis of a key innovation in an experimental Escherichia coli population

24 February 2020

cites work

1 reference

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Role of Pleiotropy in the Evolution of a Cryptic Developmental Variation in Caenorhabditis elegans

20 March 2017

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Second-order selection for evolvability in a large Escherichia coli population

20 March 2017

1 reference

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Genotype to phenotype: a complex problem

20 March 2017

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Bias and evolution of the mutationally accessible phenotypic space in a developmental system

20 March 2017

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Historical contingency and the evolution of a key innovation in an experimental population of Escherichia coli

20 March 2017

1 reference

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Cryptic genetic variation is enriched for potential adaptations

20 March 2017

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Sir2 mediates longevity in the fly through a pathway related to calorie restriction

20 March 2017

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The genetics of RNA silencing

20 March 2017

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Targeted disruption of mouse EGF receptor: effect of genetic background on mutant phenotype

20 March 2017

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Ecological Adaptation During Incipient Speciation Revealed by Precise Gene Replacement

20 March 2017

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Epidermal growth factor receptor mutations in lung cancer

7 April 2017

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Darwinian evolution can follow only very few mutational paths to fitter proteins

7 April 2017

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RNAi phenotypes are influenced by the genetic background of the injected strain.

7 April 2017

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Mutational effects depend on ploidy level: all else is not equal

29 September 2017

1 reference

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Gene-environment interplay in Drosophila melanogaster: chronic food deprivation in early life affects adult exploratory and fitness traits.

29 September 2017

1 reference

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Sexual selection is ineffectual or inhibits the purging of deleterious mutations in Drosophila melanogaster

29 September 2017

1 reference

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Relative effectiveness of mating success and sperm competition at eliminating deleterious mutations in Drosophila melanogaster

29 September 2017

1 reference

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Hsp90 is important for fecundity, longevity, and buffering of cryptic deleterious variation in wild fly populations.

29 September 2017

1 reference

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Genome-wide manipulations of Drosophila melanogaster with transposons, Flp recombinase, and ΦC31 integrase.

29 September 2017

1 reference

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Repeatability and contingency in the evolution of a key innovation in phage lambda

29 September 2017

1 reference

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Absence of effects of Sir2 overexpression on lifespan in C. elegans and Drosophila

29 September 2017

1 reference

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Ageing: longevity hits a roadblock

29 September 2017

1 reference

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Regulation of Caenorhabditis elegans lifespan by sir-2.1 transgenes

29 September 2017

1 reference

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Nonclassical Regulation of Transcription: Interchromosomal Interactions at the Malic enzyme Locus of Drosophila melanogaster

29 September 2017

1 reference

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Dietary stress does not strengthen selection against single deleterious mutations in Drosophila melanogaster

29 September 2017

1 reference

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Drosophila RNAi screening in a postgenomic world

29 September 2017

1 reference

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Reciprocal sign epistasis between frequently experimentally evolved adaptive mutations causes a rugged fitness landscape

29 September 2017

1 reference

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Initial Mutations Direct Alternative Pathways of Protein Evolution

29 September 2017

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Phenomics: the next challenge

29 September 2017

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Gene–Environment Interactions at Nucleotide Resolution

29 September 2017

1 reference

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Permissive secondary mutations enable the evolution of influenza oseltamivir resistance

29 September 2017

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The genetic signature of conditional expression

29 September 2017

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Overview of molecular testing in non-small-cell lung cancer: mutational analysis, gene copy number, protein expression and other biomarkers of EGFR for the prediction of response to tyrosine kinase inhibitors.

29 September 2017

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Long-lived Indy and calorie restriction interact to extend life span.

29 September 2017

1 reference

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Long-lived Indy induces reduced mitochondrial reactive oxygen species production and oxidative damage

29 September 2017

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Advances in breast cancer: pathways to personalized medicine

29 September 2017

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Reverse engineering the genotype-phenotype map with natural genetic variation

29 September 2017

1 reference

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Genomic consequences of background effects on scalloped mutant expressivity in the wing of Drosophila melanogaster

29 September 2017

1 reference

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Intraspecific evolution of the intercellular signaling network underlying a robust developmental system

29 September 2017

1 reference

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Gene-environment interaction in yeast gene expression

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3692003

The expression pattern of a rice disease resistance gene xa3/xa26 is differentially regulated by the genetic backgrounds and developmental stages that influence its function

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3692003

No influence of Indy on lifespan in Drosophila after correction for genetic and cytoplasmic background effects

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3692003

Mapping determinants of gene expression plasticity by genetical genomics in C. elegans

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3692003

Epidermal growth factor receptor and transforming growth factor-beta signaling contributes to variation for wing shape in Drosophila melanogaster

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3692003

Does the desaturase-2 locus in Drosophila melanogaster cause adaptation and sexual isolation?

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3692003

Pharmacogenetics/genomics and personalized medicine

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3692003

Inbreeding depression and male survivorship in Drosophila: implications for senescence theory

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3692003

Uncovering cryptic genetic variation.

29 September 2017

1 reference

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Phenotypic variation resulting from a deficiency of epidermal growth factor receptor in mice is caused by extensive genetic heterogeneity that can be genetically and molecularly partitioned

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3692003

Genotype-Environment Interactions at Quantitative Trait Loci Affecting Inflorescence Development inArabidopsis thaliana

29 September 2017

1 reference

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Sensitized polygenic trait analysis

29 September 2017

1 reference

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Developmental system drift and flexibility in evolutionary trajectories

29 September 2017

1 reference

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From genotype to phenotype: buffering mechanisms and the storage of genetic information

29 September 2017

1 reference

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Is Function of the Drosophila Homeotic Gene Ultrabithorax Canalized?

29 September 2017

1 reference

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Expression of Drosophila mushroom body mutations in alternative genetic backgrounds: a case study of the mushroom body miniature gene (mbm)

29 September 2017

1 reference

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Position effect variegation in Drosophila is associated with an altered chromatin structure.

29 September 2017

1 reference

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Epistasis between mutations is host-dependent for an RNA virus

29 September 2017

1 reference

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Epistatic natural allelic variation reveals a function of AGAMOUS-LIKE6 in axillary bud formation in Arabidopsis

2 June 2018

1 reference

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Epistatic interactions attenuate mutations affecting startle behaviour in Drosophila melanogaster

2 June 2018

1 reference

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Genetic background affects epistatic interactions between two beneficial mutations

2 June 2018

1 reference

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An intact RNA interference pathway is required for expression of the mutant wing phenotype of vg(21-3), a P-element-induced allele of the vestigial gene in Drosophila.

27 November 2018

1 reference

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The Effect of Sexual Selection on Offspring Fitness Depends on the Nature of Genetic Variation

27 November 2018

1 reference

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Negative epistasis between beneficial mutations in an evolving bacterial population

27 November 2018

1 reference

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RNAi-induced off-target effects in Drosophila melanogaster: frequencies and solutions

27 November 2018

1 reference

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Cryptic genetic variation and body size evolution in threespine stickleback.

27 November 2018

1 reference

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Diet and hormonal manipulation reveal cryptic genetic variation: implications for the evolution of novel feeding strategies.

27 November 2018

1 reference

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Cryptic intraspecific variation in sex determination in Caenorhabditis elegans revealed by mutations

27 November 2018

1 reference

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Personalized medicine in oncology: the future is now.

27 November 2018

1 reference

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A naturally occurring variant of Hsp90 that is associated with decanalization.

27 November 2018

1 reference

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Selection, epistasis, and parent-of-origin effects on deleterious mutations across environments in Drosophila melanogaster.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3692003

The effect of pathogens on selection against deleterious mutations in Drosophila melanogaster

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3692003

Longevity of Indy mutant Drosophila not attributable to Indy mutation

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3692003

Sexual selection accelerates the elimination of a deleterious mutant in Drosophila melanogaster

27 November 2018

1 reference

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Evolutionary potential of hidden genetic variation.

27 November 2018

1 reference

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Molecular analysis of flies selected for aggressive behavior.

27 November 2018

1 reference

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Proper control of genetic background with precise allele substitution: a comment on Coyne and Elwyn

27 November 2018

1 reference

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Evidence for canalization of Distal-less function in the leg of Drosophila melanogaster.

27 November 2018

1 reference

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Pervasive joint influence of epistasis and plasticity on mutational effects in Escherichia coli.

27 November 2018

1 reference

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The environmental and genetic regulation of obake expressivity: morphogenetic fields as evolvable systems.

27 November 2018

1 reference

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Evidence that Egfr contributes to cryptic genetic variation for photoreceptor determination in natural populations of Drosophila melanogaster

27 November 2018

1 reference

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A host parasite interaction rescues Drosophila oogenesis defects

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3692003

Extended life-span conferred by cotransporter gene mutations in Drosophila.

27 November 2018

1 reference

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The phenotypic plasticity of wing size in Drosophila melanogaster: the cellular basis of its genetic variation

27 November 2018

1 reference

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A study of canalization and developmental stability in the sternopleural bristle system of Drosophila melanogaster

27 November 2018

1 reference

12 December 2020

Mapping phenotypic plasticity and genotype-environment interactions affecting life-history traits in Caenorhabditis elegans

1 reference

12 December 2020

Cryptic quantitative evolution of the vulva intercellular signaling network in Caenorhabditis

1 reference

12 December 2020

Model organisms: the dangers lurking in the genetic background

1 reference

12 December 2020

A midlife crisis for sirtuins

1 reference

12 December 2020

MUTATIONAL CONTRIBUTIONS TO GENETIC VARIANCE-COVARIANCE MATRICES: AN EXPERIMENTAL APPROACH USING INDUCED MUTATIONS IN ARABIDOPSIS THALIANA

1 reference

12 December 2020

Environmental effects on body size variation in Drosophila melanogaster and its cellular basis

1 reference

12 December 2020

10.1016/J.TIG.2013.01.009

Identifiers

DOI

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23453263%20AND%20SRC:MED&resulttype=core&format=json

24 February 2020

arXiv ID

1301.2694

0 references

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23453263%20AND%20SRC:MED&resulttype=core&format=json

24 February 2020

PubMed publication ID

23453263

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23453263%20AND%20SRC:MED&resulttype=core&format=json