Use of cysteine-reactive cross-linkers to probe conformational flexibility of human DJ-1 demonstrates that Glu18 mutations are dimers (Q27683814)

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English	Use of cysteine-reactive cross-linkers to probe conformational flexibility of human DJ-1 demonstrates that Glu18 mutations are dimers	scientific article

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title

Use of cysteine-reactive cross-linkers to probe conformational flexibility of human DJ-1 demonstrates that Glu18 mutations are dimers (English)

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author

David N Hauser

object named as

David N Hauser

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2

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Mark R Cookson

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4

object named as

Mark R Cookson

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author name string

Janani Prahlad

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1

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Nicole M Milkovic

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3

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Mark A Wilson

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5

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language of work or name

English

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publication date

September 2014

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published in

Journal of Neurochemistry

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volume

130

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issue

6

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page(s)

839-53

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cites work

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Structural Impact of Three Parkinsonism-Associated Missense Mutations on Human DJ-1 † , ‡

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Sensitivity to oxidative stress in DJ-1-deficient dopamine neurons: an ES- derived cell model of primary Parkinsonism

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Down regulation of DJ-1 enhances cell death by oxidative stress, ER stress, and proteasome inhibition

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Crystal structure of DJ-1/RS and implication on familial Parkinson's disease

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20 March 2017

The 1.1-A resolution crystal structure of DJ-1, the protein mutated in autosomal recessive early onset Parkinson's disease

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The crystal structure of DJ-1, a protein related to male fertility and Parkinson's disease

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Crystal structure of human DJ-1, a protein associated with early onset Parkinson's disease

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Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism

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20 March 2017

Towards automated crystallographic structure refinement with phenix.refine

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20 March 2017

Inference of macromolecular assemblies from crystalline state

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20 March 2017

L166P mutant DJ-1, causative for recessive Parkinson's disease, is degraded through the ubiquitin-proteasome system

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20 March 2017

DJ-1, a novel oncogene which transforms mouse NIH3T3 cells in cooperation with ras

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20 March 2017

Oxidant stress evoked by pacemaking in dopaminergic neurons is attenuated by DJ-1

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20 March 2017

DJ-1-dependent regulation of oxidative stress in the retinal pigment epithelium (RPE)

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High-density miniaturized thermal shift assays as a general strategy for drug discovery

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The oxidation states of DJ-1 dictate the cell fate in response to oxidative stress triggered by 4-hpr: autophagy or apoptosis?

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29 September 2017

Parkinson-susceptibility gene DJ-1/PARK7 protects the murine heart from oxidative damage in vivo

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29 September 2017

Monomer DJ-1 and its N-terminal sequence are necessary for mitochondrial localization of DJ-1 mutants

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29 September 2017

Parkinson's disease-associated mutations in DJ-1 modulate its dimerization in living cells.

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29 September 2017

Oxidized DJ-1 inhibits p53 by sequestering p53 from promoters in a DNA-binding affinity-dependent manner

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Mitochondrial dysfunction and oxidative stress in Parkinson's disease and monogenic parkinsonism

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29 September 2017

dj-1β regulates oxidative stress, insulin-like signaling and development in Drosophila melanogaster.

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29 September 2017

Mitophagy and Parkinson's disease: be eaten to stay healthy

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29 September 2017

ROS-dependent regulation of Parkin and DJ-1 localization during oxidative stress in neurons.

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29 September 2017

Loss of DJ-1 does not affect mitochondrial respiration but increases ROS production and mitochondrial permeability transition pore opening

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Protein flexibility is key to cisplatin crosslinking in calmodulin.

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DJ-1 knock-down impairs astrocyte mitochondrial function

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29 September 2017

L10p and P158DEL DJ‐1 mutations cause protein instability, aggregation, and dimerization impairments

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29 September 2017

Loss of the Parkinson's disease-linked gene DJ-1 perturbs mitochondrial dynamics

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29 September 2017

DJ-1 is critical for mitochondrial function and rescues PINK1 loss of function

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29 September 2017

Parkinson's disease: insights from pathways

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29 September 2017

DJ-1 protects against oxidative damage by regulating the thioredoxin/ASK1 complex.

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29 September 2017

DJ-1 and prevention of oxidative stress in Parkinson's disease and other age-related disorders

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29 September 2017

Structural effects of Parkinson's disease linked DJ-1 mutations.

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29 September 2017

The Parkinson's disease gene DJ-1 is also a key regulator of stroke-induced damage.

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29 September 2017

Mutational analysis of DJ-1 in Drosophila implicates functional inactivation by oxidative damage and aging

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29 September 2017

The Parkinson's disease protein DJ-1 is neuroprotective due to cysteine-sulfinic acid-driven mitochondrial localization

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29 September 2017

A missense mutation (L166P) in DJ-1, linked to familial Parkinson's disease, confers reduced protein stability and impairs homo-oligomerization.

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29 September 2017

Quantitative evaluation of the lengths of homobifunctional protein cross-linking reagents used as molecular rulers

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29 September 2017

Identification and characterization of a novel protein that regulates RNA-protein interaction

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Molecular cloning and expression of rat contraception associated protein 1 (CAP1), a protein putatively involved in fertilization

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29 September 2017

Measurement of protein by spectrophotometry at 205 nm.

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2 June 2018

Malonate: a versatile cryoprotectant and stabilizing solution for salt-grown macromolecular crystals

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21 January 2018

Cysteine-106 of DJ-1 is the most sensitive cysteine residue to hydrogen peroxide-mediated oxidation in vivo in human umbilical vein endothelial cells

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21 January 2018

The DJ-1L166P mutant protein associated with early onset Parkinson's disease is unstable and forms higher-order protein complexes

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21 January 2018

Roles of Drosophila DJ-1 in survival of dopaminergic neurons and oxidative stress

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21 January 2018

Drosophila DJ-1 mutants are selectively sensitive to environmental toxins associated with Parkinson's disease

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21 January 2018

Molecular characterization of a thiJ-like gene in Chinese cabbage

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21 January 2018

Processing of X-ray diffraction data collected in oscillation mode

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21 January 2018

Destabilization of DJ-1 by familial substitution and oxidative modifications: implications for Parkinson's disease

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12 December 2020

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Identifiers

DOI

10.1111/JNC.12763

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PMC publication ID

4156530

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PubMed publication ID

24832775

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ResearchGate publication ID

262343877

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