Structure of the DDB1–CRBN E3 ubiquitin ligase in complex with thalidomide (Q27684738)

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13 June 2020

J Wade Harper

J Wade

Harper

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13 June 2020

Kerstin Böhm

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13 June 2020

John R Lydeard

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Haidi Yang

Haidi

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Michael B Stadler

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Jane Nagel

Jane

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Fabrizio Serluca

Fabrizio

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Vincent Acker

Vincent

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13 June 2020

Gondichatnahalli M Lingaraju

Gondichatnahalli M

Lingaraju

1 reference

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Ritesh B Tichkule

Ritesh B

Tichkule

1 reference

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13 June 2020

Michael Schebesta

Michael

Schebesta

1 reference

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William C Forrester

William C

Forrester

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13 June 2020

Markus Schirle

Markus

Schirle

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Ulrich Hassiepen

Ulrich

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Johannes Ottl

Johannes

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Marc Hild

Marc

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Rohan E J Beckwith

Rohan E J

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Jeremy L Jenkins

Jeremy L

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Nicolas H Thomä

Nicolas H

Thomä

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13 June 2020

language of work or name

English

0 references

publication date

7 August 2014

0 references

published in

Nature

1 reference

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volume

512

1 reference

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issue

7512

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page(s)

49-53

1 reference

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Cereblon is a direct protein target for immunomodulatory and antiproliferative activities of lenalidomide and pomalidomide

13 June 2020

cites work

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The molecular basis of CRL4DDB2/CSA ubiquitin ligase architecture, targeting, and activation

20 March 2017

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20 March 2017

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Identification of a primary target of thalidomide teratogenicity

20 March 2017

1 reference

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A promiscuous alpha-helical motif anchors viral hijackers and substrate receptors to the CUL4-DDB1 ubiquitin ligase machinery

20 March 2017

1 reference

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Structural basis of UV DNA-damage recognition by the DDB1-DDB2 complex

20 March 2017

1 reference

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Mechanism of auxin perception by the TIR1 ubiquitin ligase

20 March 2017

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Molecular architecture and assembly of the DDB1-CUL4A ubiquitin ligase machinery

20 March 2017

1 reference

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A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1

20 March 2017

1 reference

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ConSurf 2005: the projection of evolutionary conservation scores of residues on protein structures

20 March 2017

1 reference

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A mutation in a novel ATP-dependent Lon protease gene in a kindred with mild mental retardation

20 March 2017

1 reference

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Crystal structure of calcineurin-cyclophilin-cyclosporin shows common but distinct recognition of immunophilin-drug complexes

20 March 2017

1 reference

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Crystal structures of human calcineurin and the human FKBP12-FK506-calcineurin complex

20 March 2017

1 reference

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Thalidomide is an inhibitor of angiogenesis

20 March 2017

1 reference

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Lenalidomide causes selective degradation of IKZF1 and IKZF3 in multiple myeloma cells

20 March 2017

1 reference

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The myeloma drug lenalidomide promotes the cereblon-dependent destruction of Ikaros proteins

20 March 2017

1 reference

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Immunomodulatory agents lenalidomide and pomalidomide co-stimulate T cells by inducing degradation of T cell repressors Ikaros and Aiolos via modulation of the E3 ubiquitin ligase complex CRL4(CRBN.).

20 March 2017

1 reference

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A mental retardation-linked nonsense mutation in cereblon is rescued by proteasome inhibition

29 September 2017

1 reference

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Mechanisms and function of substrate recruitment by F-box proteins.

29 September 2017

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Thalidomide-analogue biology: immunological, molecular and epigenetic targets in cancer therapy.

29 September 2017

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Isosteric analogs of lenalidomide and pomalidomide: synthesis and biological activity

29 September 2017

1 reference

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The deubiquitinating protein USP24 interacts with DDB2 and regulates DDB2 stability

29 September 2017

1 reference

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A temporal chromatin signature in human embryonic stem cells identifies regulators of cardiac development

29 September 2017

1 reference

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The application and biology of immunomodulatory drugs (IMiDs) in cancer

29 September 2017

1 reference

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Development, validation and application of a sensitive LC-MS/MS method for the quantification of thalidomide in human serum, cells and cell culture medium.

29 September 2017

1 reference

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Cereblon expression is required for the antimyeloma activity of lenalidomide and pomalidomide.

29 September 2017

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Phase I trial of lenalidomide and CCI-779 in patients with relapsed multiple myeloma: evidence for lenalidomide-CCI-779 interaction via P-glycoprotein

29 September 2017

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Detecting UV-lesions in the genome: The modular CRL4 ubiquitin ligase does it best!

29 September 2017

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Dynamics of Cullin-RING Ubiquitin Ligase Network Revealed by Systematic Quantitative Proteomics

29 September 2017

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29 September 2017

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Substrate recognition by RNA 5-methyluridine methyltransferases and pseudouridine synthases: a structural perspective

29 September 2017

1 reference

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Transport of thalidomide by the human intestinal caco-2 monolayers

29 September 2017

1 reference

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Control of vertebrate limb outgrowth by the proximal factor Meis2 and distal antagonism of BMPs by Gremlin

29 September 2017

1 reference

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Antitumor activity of thalidomide in refractory multiple myeloma

29 September 2017

1 reference

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Further evidence for the possible role of MEIS2 in the development of cleft palate and cardiac septum.

29 September 2017

1 reference

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The evolution of thalidomide and its IMiD derivatives as anticancer agents

27 November 2018

1 reference

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THALIDOMIDE IN THE TREATMENT OF LEPRA REACTIONS

27 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25043012

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Structure of DDB1 in complex with a paramyxovirus V protein: viral hijack of a propeller cluster in ubiquitin ligase

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25043012

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

THALIDOMIDE AND CONGENITAL ABNORMALITIES

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FNATURE13527

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NATURE13527

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25043012%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

13 June 2020

1028080932

0 references

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25043012%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

PubMed publication ID

25043012

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25043012%20AND%20SRC:MED&resulttype=core&format=json