The myeloma drug lenalidomide promotes the cereblon-dependent destruction of Ikaros proteins (Q28303081)

object named as

William G Kaelin

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author name string

Gang Lu

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Richard E Middleton

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Huahang Sun

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MarkVic Naniong

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Christopher J Ott

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Constantine S Mitsiades

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James E Bradner

full work available at URL

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language of work or name

English

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publication date

17 January 2014

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4070318

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published in

Science

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volume

343

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issue

6168

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page(s)

305-9

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cites work

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Biological activity of lenalidomide and its underlying therapeutic effects in multiple myeloma

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Cereblon is a direct protein target for immunomodulatory and antiproliferative activities of lenalidomide and pomalidomide

20 March 2017

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Function of Ikaros as a tumor suppressor in B cell acute lymphoblastic leukemia

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Lenalidomide efficacy in activated B-cell-like subtype diffuse large B-cell lymphoma is dependent upon IRF4 and cereblon expression

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Molecular mechanism of action of immune-modulatory drugs thalidomide, lenalidomide and pomalidomide in multiple myeloma

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Aiolos promotes TH17 differentiation by directly silencing Il2 expression

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Cereblon expression is required for the antimyeloma activity of lenalidomide and pomalidomide.

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Ikaros in immune receptor signaling, lymphocyte differentiation, and function.

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Multicenter, phase I, dose-escalation trial of lenalidomide plus bortezomib for relapsed and relapsed/refractory multiple myeloma

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High expression of cereblon (CRBN) is associated with improved clinical response in patients with multiple myeloma treated with lenalidomide and dexamethasone.

2 June 2018

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Genome-wide identification of Ikaros targets elucidates its contribution to mouse B-cell lineage specification and pre-B-cell differentiation

27 November 2018

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High cereblon expression is associated with better survival in patients with newly diagnosed multiple myeloma treated with thalidomide maintenance.

27 November 2018

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Mutation ofFOXL2in Granulosa-Cell Tumors of the Ovary

27 November 2018

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Ikaros DNA-binding proteins as integral components of B cell developmental-stage-specific regulatory circuits.

27 November 2018

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Inhibition of HIF is necessary for tumor suppression by the von Hippel-Lindau protein

27 November 2018

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Ikaros sets thresholds for T cell activation and regulates chromosome propagation

27 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24292623

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

1 reference

https://pubmed.ncbi.nlm.nih.gov/24292623

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Negative regulators take center stage

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24292623

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1126/SCIENCE.1244917

1 reference

ADS bibcode

2014Sci...343..305L

0 references

1 reference

1 reference

PubMed publication ID

24292623

1 reference