Substrate and product analogues as human O-GlcNAc transferase inhibitors (Q27663568)

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8 February 2020

title

Substrate and product analogues as human O-GlcNAc transferase inhibitors (English)

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8 February 2020

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8 February 2020

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8 February 2020

Vladimir S Borodkin

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8 February 2020

David E Blair

series ordinal

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8 February 2020

Shalini Pathak

series ordinal

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8 February 2020

Iva Navratilova

series ordinal

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8 February 2020

publication date

17 July 2010

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8 February 2020

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8 February 2020

volume

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8 February 2020

issue

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8 February 2020

page(s)

781-792

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GlcNAcstatins are nanomolar inhibitors of human O -GlcNAcase inducing cellular hyper- O -GlcNAcylation

8 February 2020

cites work

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Structural insights into mechanism and specificity of O-GlcNAc transferase

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Structure of an O-GlcNAc transferase homolog provides insight into intracellular glycosylation

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20 March 2017

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The O-GlcNAc transferase gene resides on the X chromosome and is essential for embryonic stem cell viability and mouse ontogeny

20 March 2017

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O-Linked GlcNAc transferase is a conserved nucleocytoplasmic protein containing tetratricopeptide repeats

20 March 2017

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Dynamic glycosylation of nuclear and cytosolic proteins. Cloning and characterization of a unique O-GlcNAc transferase with multiple tetratricopeptide repeats

20 March 2017

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20 March 2017

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Refinement of macromolecular structures by the maximum-likelihood method

20 March 2017

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PRODRG: a tool for high-throughput crystallography of protein-ligand complexes

20 March 2017

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An evolving hierarchical family classification for glycosyltransferases

20 March 2017

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Cycling of O-linked beta-N-acetylglucosamine on nucleocytoplasmic proteins

20 March 2017

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The hexosamine signaling pathway: deciphering the "O-GlcNAc code"

20 March 2017

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Glycosylation of nuclear and cytoplasmic proteins. Purification and characterization of a uridine diphospho-N-acetylglucosamine:polypeptide beta-N-acetylglucosaminyltransferase

20 March 2017

1 reference

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Structure and mechanism of a bacterial beta-glucosaminidase having O-GlcNAcase activity

20 March 2017

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Streptozotocin, an O-GlcNAcase inhibitor, blunts insulin and growth hormone secretion

20 March 2017

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Alloxan is an inhibitor of the enzyme O-linked N-acetylglucosamine transferase

20 March 2017

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Nutrient sensor O-GlcNAc transferase regulates breast cancer tumorigenesis through targeting of the oncogenic transcription factor FoxM1.

20 March 2017

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In vivo imaging of Caenorhabditis elegans glycans

29 September 2017

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The hexosamine signaling pathway: O-GlcNAc cycling in feast or famine

29 September 2017

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Molecular characterization of nucleocytosolic O-GlcNAc transferases of Giardia lamblia and Cryptosporidium parvum

29 September 2017

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Molecular mechanisms of O-GlcNAcylation.

29 September 2017

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O-GlcNAc modulation at Akt1 Ser473 correlates with apoptosis of murine pancreatic beta cells

29 September 2017

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Cross-talk between GlcNAcylation and phosphorylation: roles in insulin resistance and glucose toxicity

29 September 2017

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A convenient synthesis of the C-1-phosphonate analogue of UDP-GlcNAc and its evaluation as an inhibitor of O-linked GlcNAc transferase (OGT)

29 September 2017

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O-GlcNAc modification in diabetes and Alzheimer's disease

29 September 2017

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Modification of topoisomerase I activity by glucose and by O-GlcNAcylation of the enzyme protein

29 September 2017

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Glutamine-induced protection of isolated rat heart from ischemia/reperfusion injury is mediated via the hexosamine biosynthesis pathway and increased protein O-GlcNAc levels

29 September 2017

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Modification of p53 with O-linked N-acetylglucosamine regulates p53 activity and stability

29 September 2017

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Structural insights into the mechanism and inhibition of eukaryotic O-GlcNAc hydrolysis

29 September 2017

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Molecular modeling insights into the catalytic mechanism of the retaining galactosyltransferase LgtC.

29 September 2017

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O-Linked N-Acetylglucosamine and Cancer: Messages from the Glycosylation of C-Myc

29 September 2017

1 reference

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O-GlcNAc turns twenty: functional implications for post-translational modification of nuclear and cytosolic proteins with a sugar

29 September 2017

1 reference

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Altered glycan-dependent signaling induces insulin resistance and hyperleptinemia

29 September 2017

1 reference

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Identification of a nuclear variant of MGEA5, a cytoplasmic hyaluronidase and a beta-N-acetylglucosaminidase

29 September 2017

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Glucose stimulates protein modification by O-linked GlcNAc in pancreatic beta cells: linkage of O-linked GlcNAc to beta cell death

29 September 2017

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Modulation of O-LinkedN-Acetylglucosamine Levels on Nuclear and Cytoplasmic Proteins in Vivo Using the PeptideO-GlcNAc-β-N-acetylglucosaminidase InhibitorO-(2-Acetamido-2-deoxy-dglucopyranosylidene)amino-N-phenylcarbamate

29 September 2017

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SPINDLY, a tetratricopeptide repeat protein involved in gibberellin signal transduction in Arabidopsis

29 September 2017

1 reference

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Purification and characterization of an O-GlcNAc selective N-acetyl-beta-D-glucosaminidase from rat spleen cytosol.

29 September 2017

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Increased hexosamine biosynthesis and protein O-GlcNAc levels associated with myocardial protection against calcium paradox and ischemia

29 September 2017

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O-Linked N-Acetylglucosamine Is Upregulated in Alzheimer Brains

2 June 2018

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Glycosylation of chromosomal proteins: localization of O-linked N-acetylglucosamine in Drosophila chromatin.

2 June 2018

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Ligand efficiency indices as guideposts for drug discovery.

2 June 2018

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Total synthesis and biological evaluation of the protein phosphatase 2A inhibitor cytostatin and analogues

21 January 2018

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Synthesis of the C1-phosphonate analog of UDP-GlcNAc

21 January 2018

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Antisense glutaminase inhibition modifies the O-GlcNAc pattern and flux through the hexosamine pathway in breast cancer cells.

21 January 2018

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Discovery of O-GlcNAc transferase inhibitors

21 January 2018

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Alpha-GlcNAc thioconjugates

21 January 2018

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Accumulation of protein O-GlcNAc modification inhibits proteasomes in the brain and coincides with neuronal apoptosis in brain areas with high O-GlcNAc metabolism

21 January 2018

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Cardiovascular effects of endomorphins in alloxan-induced diabetic rats

21 January 2018

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O-GlcNAcase uses substrate-assisted catalysis: kinetic analysis and development of highly selective mechanism-inspired inhibitors.

21 January 2018

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A divergent synthesis of 2-acyl derivatives of PUGNAc yields selective inhibitors of O-GlcNAcase.

21 January 2018

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O-GlcNAc modification: a nutritional sensor that modulates proteasome function

21 January 2018

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Nucleocytoplasmic glycosylation, O-GlcNAc: identification and site mapping

21 January 2018

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Reduction of O-LinkedN-Acetylglucosamine-Modified Assembly Protein-3 in Alzheimer’s Disease

27 November 2018

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Synthesis and characterization of an anomeric sulfur analogue of CMP-sialic acid

27 November 2018

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12 December 2020

Improved chemical synthesis of UDP-galactofuranose

1 reference

12 December 2020

Thiol-group reactivity, hydrophilicity and stability of alloxan, its reduction products and its N-methyl derivatives and a comparison with ninhydrin

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12 December 2020

Topography and polypeptide distribution of terminal N-acetylglucosamine residues on the surfaces of intact lymphocytes. Evidence for O-linked GlcNAc

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12 December 2020

10.1007/S00726-010-0688-Y

Identifiers

DOI

1 reference

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Dimensions Publication ID

8 February 2020

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8 February 2020

PubMed publication ID

20640461

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20640461%20AND%20SRC:MED&resulttype=core&format=json