Structure of HIV-1 Reverse Transcriptase with the Inhibitor β-Thujaplicinol Bound at the RNase H Active Site (Q27658584)

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Karen A Maegley

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Tom A Pauly

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Joseph D Bauman

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Kalyan Das

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Chhaya Dharia

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Arthur D Clark

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Kevin Ryan

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Michael J Hickey

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Robert A Love

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Simon Bergqvist

Crystal engineering of HIV-1 reverse transcriptase for structure-based drug design

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publication date

9 December 2009

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1625-35

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cites work

1 reference

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Structure of human RNase H1 complexed with an RNA/DNA hybrid: insight into HIV reverse transcription

20 March 2017

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HIV-1 Reverse Transcriptase Structure with RNase H Inhibitor Dihydroxy Benzoyl Naphthyl Hydrazone Bound at a Novel Site

20 March 2017

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Selective inhibition of HIV-1 reverse transcriptase-associated ribonuclease H activity by hydroxylated tropolones

20 March 2017

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Two-metal ion mechanism of RNA cleavage by HIV RNase H and mechanism-based design of selective HIV RNase H inhibitors

20 March 2017

1 reference

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Crystal structure of HIV-1 reverse transcriptase in complex with a polypurine tract RNA:DNA

20 March 2017

1 reference

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Co-crystal of Escherichia coli RNase HI with Mn2+ ions reveals two divalent metals bound in the active site

20 March 2017

1 reference

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Structure of a covalently trapped catalytic complex of HIV-1 reverse transcriptase: implications for drug resistance

20 March 2017

1 reference

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Structure of unliganded HIV-1 reverse transcriptase at 2.7 A resolution: implications of conformational changes for polymerization and inhibition mechanisms

20 March 2017

1 reference

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A general two-metal-ion mechanism for catalytic RNA

20 March 2017

1 reference

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Crystal structure of Escherichia coli RNase HI in complex with Mg2+ at 2.8 A resolution: proof for a single Mg(2+)-binding site

20 March 2017

1 reference

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Crystal structures of cellular retinoic acid binding proteins I and II in complex with all-trans-retinoic acid and a synthetic retinoid

20 March 2017

1 reference

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Structure of ribonuclease H phased at 2 A resolution by MAD analysis of the selenomethionyl protein

20 March 2017

1 reference

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Coot: model-building tools for molecular graphics

20 March 2017

1 reference

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Refinement of macromolecular structures by the maximum-likelihood method

20 March 2017

1 reference

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Pushing the boundaries of molecular replacement with maximum likelihood

20 March 2017

1 reference

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Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

20 March 2017

1 reference

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Improved methods for building protein models in electron density maps and the location of errors in these models

20 March 2017

1 reference

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Exosite-driven substrate specificity and function in coagulation

20 March 2017

1 reference

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Crystal structure at 3.5 A resolution of HIV-1 reverse transcriptase complexed with an inhibitor

20 March 2017

1 reference

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Crystal structures of RNase H bound to an RNA/DNA hybrid: substrate specificity and metal-dependent catalysis

7 April 2017

1 reference

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Checking your imagination: applications of the free R value

7 April 2017

1 reference

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Crystal structure of human immunodeficiency virus type 1 reverse transcriptase complexed with double-stranded DNA at 3.0 A resolution shows bent DNA

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3365588

HIV-1 reverse transcriptase can simultaneously engage its DNA/RNA substrate at both DNA polymerase and RNase H active sites: implications for RNase H inhibition

7 April 2017

1 reference

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The naphthyridinone GSK364735 is a novel, potent human immunodeficiency virus type 1 integrase inhibitor and antiretroviral

29 September 2017

1 reference

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Recent progress in the design of small molecule inhibitors of HIV RNase H.

29 September 2017

1 reference

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Taking aim at a moving target: designing drugs to inhibit drug-resistant HIV-1 reverse transcriptases

29 September 2017

1 reference

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A fluorescence-based high-throughput screening assay for inhibitors of human immunodeficiency virus-1 reverse transcriptase-associated ribonuclease H activity

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3365588

Diketo acid inhibitor mechanism and HIV-1 integrase: implications for metal binding in the active site of phosphotransferase enzymes

29 September 2017

1 reference

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Crystal structure of the ribonuclease H domain of HIV-1 reverse transcriptase

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3365588

How does RNase H recognize a DNA.RNA hybrid?

29 September 2017

1 reference

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Mechanism of Mos1 transposition: insights from structural analysis

29 September 2017

1 reference

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Inhibition of HIV-1 ribonuclease H by a novel diketo acid, 4-[5-(benzoylamino)thien-2-yl]-2,4-dioxobutanoic acid

2 June 2018

1 reference

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Protein–nucleic acid interactions and DNA conformation in a complex of human immunodeficiency virus type 1 reverse transcriptase with a double-stranded DNA template-primer

2 June 2018

1 reference

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Mutations within the RNase H Domain of Human Immunodeficiency Virus Type 1 Reverse Transcriptase Abolish Virus Infectivity

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3365588

Binding affinities of retinol and related compounds to retinol binding proteins

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3365588

Binding of metal ions toE. coli RNase HI observed by1H−15N heteronuclear 2D NMR

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3365588

Substrate-dependent inhibition kinetics of an active site-directed inhibitor of ADAMTS-4 (Aggrecanase 1).

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3365588

Economical parallel protein expression screening and scale-up in Escherichia coli

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3365588

Activity of the isolated HIV RNase H domain and specific inhibition by N-hydroxyimides

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3365588

Activation/attenuation model for RNase H. A one-metal mechanism with second-metal inhibition.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3365588

Crystallization of human immunodeficiency virus type 1 reverse transcriptase with and without nucleic acid substrates, inhibitors, and an antibody Fab fragment

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3365588

Role of histidine 124 in the catalytic function of ribonuclease HI from Escherichia coli.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3365588

Thermal stability of Escherichia coli ribonuclease HI and its active site mutants in the presence and absence of the Mg2+ ion. Proposal of a novel catalytic role for Glu48

27 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20004166

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.STR.2009.09.016

1 reference

release_go27tw7sxjgdjcoykjqwskii6e

Fatcat ID

0 references

1 reference

1 reference

PubMed publication ID

20004166

1 reference