HIV-1 reverse transcriptase can simultaneously engage its DNA/RNA substrate at both DNA polymerase and RNase H active sites: implications for RNase H inhibition (Q34849844)

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English	HIV-1 reverse transcriptase can simultaneously engage its DNA/RNA substrate at both DNA polymerase and RNase H active sites: implications for RNase H inhibition	scientific article

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scholarly article

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Europe PubMed Central

PubMed publication ID

4 August 2017

HIV-1 reverse transcriptase can simultaneously engage its DNA/RNA substrate at both DNA polymerase and RNase H active sites: implications for RNase H inhibition (English)

1 reference

Europe PubMed Central

PubMed publication ID

4 August 2017

author name string

Greg L Beilhartz

1

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Europe PubMed Central

PubMed publication ID

4 August 2017

Michaela Wendeler

2

1 reference

Europe PubMed Central

PubMed publication ID

4 August 2017

Noel Baichoo

3

1 reference

Europe PubMed Central

PubMed publication ID

4 August 2017

Jason Rausch

4

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Europe PubMed Central

PubMed publication ID

4 August 2017

Stuart Le Grice

5

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Europe PubMed Central

PubMed publication ID

4 August 2017

Matthias Götte

6

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Europe PubMed Central

PubMed publication ID

4 August 2017

language of work or name

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publication date

13 March 2009

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Europe PubMed Central

PubMed publication ID

4 August 2017

number of pages

13

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Journal of Molecular Biology

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Europe PubMed Central

PubMed publication ID

4 August 2017

388

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Europe PubMed Central

PubMed publication ID

4 August 2017

3

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Europe PubMed Central

PubMed publication ID

4 August 2017

462-474

1 reference

Europe PubMed Central

PubMed publication ID

4 August 2017

Delayed chain termination protects the anti-hepatitis B virus drug entecavir from excision by HIV-1 reverse transcriptase

1 reference

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8 July 2018

Vinylogous ureas as a novel class of inhibitors of reverse transcriptase-associated ribonuclease H activity

1 reference

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8 July 2018

RNase H activity: structure, specificity, and function in reverse transcription

1 reference

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8 July 2018

The design of drugs for HIV and HCV

1 reference

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8 July 2018

Structure of human RNase H1 complexed with an RNA/DNA hybrid: insight into HIV reverse transcription

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4285699

8 July 2018

Stable complexes formed by HIV-1 reverse transcriptase at distinct positions on the primer-template controlled by binding deoxynucleoside triphosphates or foscarnet

1 reference

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8 July 2018

The pyrophosphate analogue foscarnet traps the pre-translocational state of HIV-1 reverse transcriptase in a Brownian ratchet model of polymerase translocation

1 reference

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8 July 2018

Indolopyridones inhibit human immunodeficiency virus reverse transcriptase with a novel mechanism of action

1 reference

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8 July 2018

Recent progress in the design of small molecule inhibitors of HIV RNase H.

1 reference

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8 July 2018

Effects of nucleotides and nucleotide analogue inhibitors of HIV-1 reverse transcriptase in a ratchet model of polymerase translocation

1 reference

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Efficient incorporation of unnatural amino acids into proteins in Escherichia coli.

1 reference

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Inhibition of human immunodeficiency virus type 1 reverse transcriptase, RNase H, and integrase activities by hydroxytropolones.

1 reference

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8 July 2018

Selective inhibition of HIV-1 reverse transcriptase-associated ribonuclease H activity by hydroxylated tropolones

1 reference

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8 July 2018

A fluorescence-based high-throughput screening assay for inhibitors of human immunodeficiency virus-1 reverse transcriptase-associated ribonuclease H activity

1 reference

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8 July 2018

Two-metal ion mechanism of RNA cleavage by HIV RNase H and mechanism-based design of selective HIV RNase H inhibitors

1 reference

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8 July 2018

Inhibition of HIV-1 ribonuclease H by a novel diketo acid, 4-[5-(benzoylamino)thien-2-yl]-2,4-dioxobutanoic acid

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4285699

8 July 2018

Structures of HIV-1 reverse transcriptase with pre- and post-translocation AZTMP-terminated DNA.

1 reference

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8 July 2018

Crystal structure of HIV-1 reverse transcriptase in complex with a polypurine tract RNA:DNA

1 reference

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8 July 2018

Structure of a covalently trapped catalytic complex of HIV-1 reverse transcriptase: implications for drug resistance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4285699

8 July 2018

Localization of the active site of HIV-1 reverse transcriptase-associated RNase H domain on a DNA template using site-specific generated hydroxyl radicals

1 reference

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8 July 2018

Inhibition of the ribonuclease H and DNA polymerase activities of HIV-1 reverse transcriptase by N-(4-tert-butylbenzoyl)-2-hydroxy-1-naphthaldehyde hydrazone

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4285699

8 July 2018

A model for the mechanism of polymerase translocation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4285699

8 July 2018

Determinants of the RNase H cleavage specificity of human immunodeficiency virus reverse transcriptase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4285699

8 July 2018

Crystal structure of human immunodeficiency virus type 1 reverse transcriptase complexed with double-stranded DNA at 3.0 A resolution shows bent DNA

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4285699

8 July 2018

HIV-1 reverse transcriptase-associated RNase H cleaves RNA/RNA in arrested complexes: implications for the mechanism by which RNase H discriminates between RNA/RNA and RNA/DNA

1 reference

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Nevirapine alters the cleavage specificity of ribonuclease H of human immunodeficiency virus 1 reverse transcriptase

1 reference

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8 July 2018

Use of an oligoribonucleotide containing the polypurine tract sequence as a primer by HIV reverse transcriptase

1 reference

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8 July 2018

Plus-strand origin for human immunodeficiency virus type 1: implications for integration

1 reference

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Mutations of a conserved residue within HIV-1 ribonuclease H affect its exo- and endonuclease activities

1 reference

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Human immunodeficiency virus reverse transcriptase ribonuclease H: specificity of tRNALys3-primer excision

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4285699

8 July 2018

Crystal structure of the ribonuclease H domain of HIV-1 reverse transcriptase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4285699

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Reverse transcriptase.RNase H from the human immunodeficiency virus. Relationship of the DNA polymerase and RNA hydrolysis activities

1 reference

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Processing of the primer for plus strand DNA synthesis by human immunodeficiency virus 1 reverse transcriptase

1 reference

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Specificity of human immunodeficiency virus-1 reverse transcriptase-associated ribonuclease H in removal of the minus-strand primer, tRNA(Lys3)

1 reference

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Incomplete removal of the RNA primer for minus-strand DNA synthesis by human immunodeficiency virus type 1 reverse transcriptase

1 reference

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Mechanism and fidelity of HIV reverse transcriptase

1 reference

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Human immunodeficiency virus type 1 reverse transcriptase: spatial and temporal relationship between the polymerase and RNase H activities

1 reference

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Mechanisms that prevent template inactivation by HIV-1 reverse transcriptase RNase H cleavages.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4285699

26 October 2018

Dissecting the effects of DNA polymerase and ribonuclease H inhibitor combinations on HIV-1 reverse-transcriptase activities

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4285699

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Site- and subunit-specific incorporation of unnatural amino acids into HIV-1 reverse transcriptase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4285699

26 October 2018

Activity of the isolated HIV RNase H domain and specific inhibition by N-hydroxyimides

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4285699

26 October 2018

Site-specific footprinting reveals differences in the translocation status of HIV-1 reverse transcriptase. Implications for polymerase translocation and drug resistance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4285699

26 October 2018

Destabilization of the HIV-1 reverse transcriptase dimer upon interaction with N-acyl hydrazone inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4285699

26 October 2018

Mutational analysis of Tyr-501 of HIV-1 reverse transcriptase. Effects on ribonuclease H activity and inhibition of this activity by N-acylhydrazones

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4285699

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Rapid purification of homodimer and heterodimer HIV-1 reverse transcriptase by metal chelate affinity chromatography.

1 reference

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Nucleotide-induced stable complex formation by HIV-1 reverse transcriptase

1 reference

https://pubmed.ncbi.nlm.nih.gov/19289131

12 December 2020

based on heuristic

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Temporal coordination between initiation of HIV (+)-strand DNA synthesis and primer removal

1 reference

https://pubmed.ncbi.nlm.nih.gov/19289131

12 December 2020

based on heuristic

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Substrate-dependent inhibition or stimulation of HIV RNase H activity by non-nucleoside reverse transcriptase inhibitors (NNRTIs)

1 reference

https://pubmed.ncbi.nlm.nih.gov/19289131

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1016/J.JMB.2009.03.025

1 reference

Europe PubMed Central

PubMed publication ID

4 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

4 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

4 August 2017

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