Structure of Insoluble Rat Sperm Glyceraldehyde-3-phosphate Dehydrogenase (GAPDH) via Heterotetramer Formation with Escherichia coli GAPDH Reveals Target for Contraceptive Design (Q27656083)

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English	Structure of Insoluble Rat Sperm Glyceraldehyde-3-phosphate Dehydrogenase (GAPDH) via Heterotetramer Formation with Escherichia coli GAPDH Reveals Target for Contraceptive Design	scientific article

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Structure of Insoluble Rat Sperm Glyceraldehyde-3-phosphate Dehydrogenase (GAPDH) via Heterotetramer Formation with Escherichia coli GAPDH Reveals Target for Contraceptive Design (English)

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Escherichia coli

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Jan Frayne

1

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ORCID Public Data File 2021

author name string

Abby Taylor

2

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Gus Cameron

3

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Andrea T Hadfield

4

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language of work or name

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publication date

21 August 2009

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Journal of Biological Chemistry

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284

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34

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22703-12

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Structure of rabbit-muscle glyceraldehyde-3-phosphate dehydrogenase

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Conformational changes in Leishmania mexicana glyceraldehyde-3-phosphate dehydrogenase induced by designed inhibitors

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20 March 2017

Human glyceraldehyde 3-phosphate dehydrogenase-2 gene is expressed specifically in spermatogenic cells

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20 March 2017

Structure-based design of submicromolar, biologically active inhibitors of trypanosomatid glyceraldehyde-3-phosphate dehydrogenase

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20 March 2017

Comparison of the structures of wild-type and a N313T mutant of Escherichia coli glyceraldehyde 3-phosphate dehydrogenases: implication for NAD binding and cooperativity

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20 March 2017

Studies of asymmetry in the three-dimensional structure of lobster D-glyceraldehyde-3-phosphate dehydrogenase

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20 March 2017

Susceptibility of glycolytic enzyme activity and motility of spermatozoa from rat, mouse, and human to inhibition by proven and putative chlorinated antifertility compounds in vitro

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20 March 2017

Expression of the spermatogenic cell-specific glyceraldehyde 3-phosphate dehydrogenase (GAPDS) in rat testis

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20 March 2017

High-resolution structure of human D-glyceraldehyde-3-phosphate dehydrogenase

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20 March 2017

Adenosine analogues as selective inhibitors of glyceraldehyde-3-phosphate dehydrogenase of Trypanosomatidae via structure-based drug design

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20 March 2017

Glyceraldehyde 3-phosphate dehydrogenase is bound to the fibrous sheath of mammalian spermatozoa

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20 March 2017

Glyceraldehyde 3-phosphate dehydrogenase-S, a sperm-specific glycolytic enzyme, is required for sperm motility and male fertility

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20 March 2017

Glyceraldehyde 3-phosphate dehydrogenase-S protein distribution during mouse spermatogenesis

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20 March 2017

Glycolysis and sperm motility: does a spoonful of sugar help the flagellum go round?

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29 September 2017

Glycolysis as a target for the design of new anti-trypanosome drugs.

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29 September 2017

alpha-chlorohydrin induced changes in sperm fertilizing ability in the rat: association with diminished sperm ATP levels and motility

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29 September 2017

Metabolic control analysis of glycolysis in trypanosomes as an approach to improve selectivity and effectiveness of drugs.

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29 September 2017

Selective inhibition of trypanosomal glyceraldehyde-3-phosphate dehydrogenase by protein structure-based design: toward new drugs for the treatment of sleeping sickness.

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29 September 2017

Molecular mechanisms and therapeutic approaches to the treatment of African trypanosomiasis

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29 September 2017

Male antifertility compounds: U-5897 as a rat chemosterilant

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29 September 2017

Expression of a glyceraldehyde 3-phosphate dehydrogenase gene specific to mouse spermatogenic cells

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29 September 2017

Sequence and structure of D-glyceraldehyde 3-phosphate dehydrogenase from Bacillus stearothermophilus

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29 September 2017

The investigation of regulatory transition in D-glyceraldehyde-3-phosphate dehydrogenase quaternary structure

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29 September 2017

The investigation of substrate-induced changes in subunit interactions in glyceraldehyde 3-phosphate dehydrogenases by measurement of the kinetics and thermodynamics of subunit exchange

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29 September 2017

Activities of various 6-chloro-6-deoxysugars and (S) alpha-chlorohydrin in producing spermatocoeles in rats and paralysis in mice and in inhibiting glucose metabolism in bull spermatozoa in vitro

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2 June 2018

The activity of glyceraldehyde 3-phosphate dehydrogenase in spermatozoa from different regions of the epididymis in laboratory rodents treated with alpha-chlorohydrin or 6-chloro-deoxyglucose.

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2 June 2018

Male antifertility compounds: efficacy of U-5897 in primates (Macacamulatta).

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2 June 2018

Hybridization of glyceraldehyde-3-phosphate dehydrogenase

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2 June 2018

The hybridization of glyceraldehyde 3-phosphate dehydrogenases from rabbit muscle and yeast. Kinetics and thermodynamics of the reaction and isolation of the hybrid

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2 June 2018

Low Resolution Structure of Glyceraldehyde 3-Phosphate Dehydrogenase

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2 June 2018

Mode of action of α-chlorohydrin as a male anti-fertility agent. Inhibition of the metabolism of ram spermatozoa by α-chlorohydrin and location of block in glycolysis

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2 June 2018

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Selective tight binding inhibitors of trypanosomal glyceraldehyde-3-phosphate dehydrogenase via structure-based drug design.

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Synthesis and structure-activity relationships of analogs of 2'-deoxy-2'-(3-methoxybenzamido)adenosine, a selective inhibitor of trypanosomal glycosomal glyceraldehyde-3-phosphate dehydrogenase.

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21 January 2018

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21 January 2018

PROCHECK: a program to check the stereochemical quality of protein structures

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Processing of X-ray diffraction data collected in oscillation mode

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21 January 2018

The role of glucose in supporting motility and capacitation in human spermatozoa

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27 November 2018

In vitro inhibition of rat cauda epididymal sperm glycolytic enzymes by ornidazole, alpha-chlorohydrin and 1-chloro-3-hydroxypropanone

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12 December 2020

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The role of sulfhydryl groups in the activity of D-glyceraldehyde 3-phosphate dehydrogenase

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12 December 2020

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An extragonadal male antifertility agent

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https://pubmed.ncbi.nlm.nih.gov/19542219

12 December 2020

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Nature and site of action of 3-chloro-1,2-propanediol--an oral antifertility agent for the male

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https://pubmed.ncbi.nlm.nih.gov/19542219

12 December 2020

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The action of (R)- and (S)-alpha-chlorohydrin and their metabolites on the metabolism of boar sperm

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https://pubmed.ncbi.nlm.nih.gov/19542219

12 December 2020

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Formation of the active antifertility metabolite of (S)-alpha-chlorohydrin in boar sperm

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https://pubmed.ncbi.nlm.nih.gov/19542219

12 December 2020

based on heuristic

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The effect of 6-chloro-6-deoxysugars on adenine nucleotide concentrations in and motility of rat spermatozoa

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https://pubmed.ncbi.nlm.nih.gov/19542219

12 December 2020

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Induction of reversible infertility in male rats by oral ornidazole and its effects on sperm motility and epididymal secretions

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https://pubmed.ncbi.nlm.nih.gov/19542219

12 December 2020

based on heuristic

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